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PRIMARY STUDY ON BIOLOGICAL ACTIVITIES AND CHEMICAL CONSTITUENTS OF ANOECTOCHILUS ROXBURGHII WALL OF VIET NAM Author Ngo Thi Phuong, Bui Kim Anh, Giang Thi Kim Lien, Nguyen Thi Thanh Huong, Le Ngoc Hu[.]
PRIMARY STUDY ON BIOLOGICAL ACTIVITIES AND CHEMICAL CONSTITUENTS OF ANOECTOCHILUS ROXBURGHII WALL OF VIET NAM Author: Ngo Thi Phuong, Bui Kim Anh, Giang Thi Kim Lien, Nguyen Thi Thanh Huong, Le Ngoc Hung, Nguyen Tuan Anh, Le Minh Ha Institute of Natural Product Chemistry, Vietnam Academy of Science and Technology (VAST); Insitute of Chemistry, VAST; The University of DaNang; giangkimlien@gmail.com Thai Nguyen University of Education; Center for training, consultancy & technology transfer, VAST; Hanoi University of Science and Technology Abstract: The total methanol extract of whole plants of Anoectochilus roxbughii (Orchidaceae) from Kontum, Viet Nam is evaluated to have antibacterial and antioxidant properties The results indicate that at concentration of 200µg/ml, the extract shows weak activities The methanol extract is filtered, combined, and concentrated under low pressure to give 16g residue, which is fractionated by chromatography column eluting in turn with n-hexane, ethyl acetate, and methanol to obtain fractions-extracts after leaving solvents Two compounds kinsenoside (1) and daucosterol (2), are isolated from the methanol and n-hexane fractions of this plant Their structures are determined by mass, 1D and 2D NMR spectra Especially, kinsenoside appears to have highly antihypertensive, hepatoprotective activities and inhibits the production of inflammatory mediators Key words: Anoectochilus roxbughi; Kinsenoside; Daucosterol; Hepatoprotective activities; Antibacterial activity; Antioxidant activity