quinones and quinone enzymes, part b

METHODS IN ENZYMOLOGY EDITORS-IN-CHIEF John N. Abelson Melvin I. Simon DIVISION OF BIOLOGY CALIFORNIA INSTITUTE OF TECHNOLOGY PASADENA, CALIFORNIA FOUNDING EDITORS Sidney P. Colowick and Nathan O. Kaplan Contributors to Volume 382 Article numbers are in parentheses and following the names of contributors. Affiliations listed are current. L. Mario Amzel (9), Interim Director, Department of Biophysics and Bio- physical Chemistry, The Johns Hop- kins University School of Medicine, Baltimore, Maryland 21205 Z ´ ilvinas Anusevic ˇ ius (15), Institute of Biochemistry, LT-2600 Vilnius, Lithuania Gad Asher (16), Department of Molecu- lar Genetics, Weizmann Institute of Science, Rehovot 76100, Israel Michel Aubier (4), Laboratoire de Bio- physique and IFR 02, Faculte ´ X. Bichat, 75018 Paris, France Alessandra Baracca (1), Dipartimento Di Biochimica, Universita Di Bologna, 40126 Bologna, Italy Raymond P. Baumann (12), Department of Pharmacology and Developmental Therapeutics Program, Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06520 M. Flint Beal (26), Department of Neu- rology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021 Asher Begleiter (18), Manitoba Institute of Cell Biology, CancerCare Manitoba, Department of Internal Medicine; De- partment of Pharmacology and Thera- peutics, University of Manitoba, Manitoba R3E 0V9, Canada Rosario I. Bello (13), Departamento de Biologı ´ a Celular, Fisiologı ´ a, e Immunol- gı ´ a, Campus Rabanales, Universidad de Co ´ rdoba, 14014 Co ´ rdoba, Spain Mario A. Bianchet (9), Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Jorge Boczkowski (4), Laboratoire de Biophysique and IFR 02, Faculte ´ X. Bichat, 75018 Paris, France Micahel K. Bowman (2), William R. Wi- ley Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland Washington 99352 John Butler (10), Department of Biologi- cal Sciences, The University of Salford, Salford M5 4WT, United Kingdom Jonathan Cape (2), Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164-6340 Maria Cecilia Carreras (4), Laboratory of Oxygen Metabolism, University Hos- pital, University of Buenos Aires, 1120 Buenos Aires, Argentina Ercole Cavalieri (17), Eppley Institute for Research in Cancer and Allied Dis- eases, University of Nebraska Medical Center, Omaha, Nebraska 68198-6805 Narimantas C ˇ e ` nas (15), Institute of Bio- chemistry, LT-2600 Vilnius, Lithuania Dhrubajyoti Chakravarti (17), Eppley Institute for Research in Cancer and Al- lied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198-6805 Tom S. Chan (6), Department of Pharma- ceutical Sciences, University of Toronto, Toronto, Ontario M5S 2S2, Canada xi Shiuan Chen (11), Department of Sur- gery, Beckman Research Institute of the City of Hope, Duarte, California 91010-0269 Ching Kuang Chow (7), Graduate Center for Nutritional Sciences and Kentucky Agricultural Experiment Station, Univer- sity of Kentucky, Lexington, Kentucky 40506 Angela DiFrancesco (10), Division of Pediatric Oncology, Policlinico Gemelli, 00168 Rome, Italy Albena T. Dinkova-Kostova (14, 19, 23), Department of Pharmacology and Mo- lecular Science, Lewis B. and Dorothy Cullman Cancer Center Chemoprotec- tion Center, Johns Hopkins University School of Medicine; Center for Human Nutrition, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205-2185 Manuchair Ebadi (27), School of Medi- cine and Health Sciences, University of North Dakota, Grand Forks, North Dakota 58203 Joshua Eken (27), School of Medicine and Health Sciences, University of North Da- kota, Grand Forks, North Dakota 58203 Hesham El Rafaey (27), School of Med- icine and Health Sciences, University of North Dakota, Grand Forks, North Dakota 58203 Margarita Faig (9), Department of Bio- physics and Biophysical Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Jed W. Fahey (14, 23), Department of Phar- macology and Molecular Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2185 Romana Fato (1), Dipartimento Di Bio- chimica, Universita Di Bologna, 40126 Bologna, Italy Jeanne Fourie (18), Manitoba Institute of Cell Biology, CancerCare Manitoba, Department of Pharmacology and Thera- peutics, University of Manitoba, Manitoba R3E 0V9, Canada Maria Luisa Genova (1), Dipartimento Di Biochimica, Universita Di Bologna, 40126 Bologna, Italy Consuelo Go ´ mez-Dı ´ az (13), Departa- mento de Biologı ´ a Celular, Fisiologı ´ a, e Immunolgı ´ a, Campus Rabanales, Uni- versidad de Co ´ rdoba, 14014 Co ´ rdoba, Spain Cindy Hagen (27), School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota 58203 Andrew M. James (3), Medical Research Council, Dun Human Nutrition Unit, Cambridge CB2 2XY, United Kingdom Elizabeth H. Jeffery (25), Department of Food Science and Human Nutrition, University of Illinois, Urbana, Illinois 61801 Young-Hwa Kang (21), College of Phar- macy, University of Illinois at Chicago, Chicago, Illinois 60612 Thomas W. Kensler (22), Department of Environmental Health Sciences, School of Public Health, Johns Hopkins Uni- versity Bloomberg, Baltimore, Maryland 21205 Geoffrey F. Kelso (3), Department of Chemistry, University of Otago, Dunedin, New Zealand Mohsen Kheradphezhou (27), School of Medicine and Health Sciences, Univer- sity of North Dakota, Grand Forks, North Dakota 58203 Richard J. Knox (11), Enact Pharma PLC, Salisbury SP4 0JQ, United Kingdom xii contributors to volume 382 David M. Kramer (2), Institute of Biologi- cal Chemistry, Washington State Univer- sity, Pullman, Washington 99164-6340 Mi-Young Kwak (22), Department of En- vironmental Health Sciences, School of Public Health, Johns Hopkins Univer- sity Bloomberg, Baltimore, Maryland 21205 Giorgio Lenaz (1), Dipartimento Di Bio- chimica, Universita Di Bologna, 40126 Bologna, Italy Constanza L. Lisdero (4), Laboratory of Oxygen Metabolism, University Hospi- tal, University of Buenos Aires, 1120 Buenos Aires, Argentina Joseph Lotem (16), Department of Mole- cular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel Mariana Melani (4), Laboratory of Oxy- gen Metabolism, University Hospital, University of Buenos Aires, 1120 Buenos Aires, Argentina Alain Meulemans (4), Laboratoire de Biophysique and IFR 02, Faculte ´ X. Bichat, 75018 Paris, France Lina Misevic ˇ iene ` (15), Institute of Bio- chemistry, LT-2600 Vilnius, Lithuania Arnold Munnich (5), Department of Ge- netics, Ho ˆ pital Necker-Enfants Malades, 75014 Paris, France Florian Muller (2), Institute of Biologi- cal Chemistry, Washington State Univer- sity, Pullman, Washington 99164-6340 Micahel P. Murphy (3), Medical Re- search Council, Dun Human Nutrition Unit, Cambridge CB2 2XY, United Kingdom Christine M. Munday (24), AgResearch, Ruakura Agricultural Research Centre, Hamilton, New Zealand Rex Munday (20, 24), AgResearch, Rua- kura Agricultural Research Centre, Ha- milton, New Zealand Pla ´ cido Navas (13), Centro Andaluz de Biologı ´ a del Desarrollo, Universidad Pablo de Olavide, 41013 Sevilla, Spain Henrikas Nivinskas (15), Institute of Bio- chemistry, LT-2600 Vilnius, Lithuania Peter J. O’brien (6), Department of Pharma- ceutical Sciences, University of Toronto, Toronto, Ontario M5S 2S2, Canada Philip J. Penketh (12), Department of Pharmacology and Developmental Therapeutics Program, Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06520 John M. Pezzuto (21), Schools of Phar- macy, Nursing, and Health Sciences, Pur- due University, West Lafayette, Indiana 47907-7880 Juan Jose ´ Poderoso (4), Laboratory of Oxygen Metabolism, University Hospi- tal, University of Buenos Aires, 1120 Buenos Aires, Argentina Minerva Ramos-Gomez (22), Department of Environmental Health Sciences, School of Public Health, Johns Hopkins Univer- sity Bloomberg, Baltimore, Maryland 21205 Arthur G. Roberts (2), Institute of Biolo- gical Chemistry, Washington State Uni- versity, Pullman, Washington 99164-6340 Eleanor Rogan (17), Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198-6805 David Ross (8), Department of Phar- maceutical Sciences, School of Phar- macy, University of Colorado, Denver, Colorado 80262 contributors to volume 382 xiii Agne ` s Ro ¨ tig (5), Department of Genetics, Ho ˆ pital Necker-Enfants Malades, 75014 Paris, France Pierre Rustin (5), Department of Genet- ics, Ho ˆ pital Necker-Enfants Malades, 75014 Paris, France Leo Sachs (16), Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel Jonas S ˇ arlauskas (15), Institute of Bio- chemistry, LT-2600 Vilnius, Lithuania Alan C. Sartorelli (12), Department of Pharmacology and Developmental Ther- apeutics Program, Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06520 Helen A. Seow (12), Department of Phar- macology and Developmental Thera- peutics Program, Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06520 Yosef Shaul (16), Department of Molecu- lar Genetics, Weizmann Institute of Science, Rehovot 76100, Israel Sushil Sharma (27), School of Medicine and Health Sciences, University of North Da- kota, Grand Forks, North Dakota 58203 Shaik Shavali (27), School of Medicine and Health Sciences, University of North Da- kota, Grand Forks, North Dakota 58203 David Siegel (8), Department of Pharma- ceutical Sciences, School of Pharmacy, University of Colorado, Denver, Colorado 80262 Robin A.J. Smith (3), Department of Chemistry, University of Otago, Dune- din, New Zealand Katherine K. Stephenson (14), Depart- ment of Pharmacology and Molecular Science, Lewis B. and Dorothy Cullman Cancer Center Chemoprotection Center, Johns Hopkins University School of Med- icine, Baltimore, Maryland 21205-2185 Kristin E. Stewart (25), Division of Nu- tritional Sciences, University of Illinois, Urbana, Illinois 61801 Paul Talalay (14, 19, 23), Department of Pharmacology and Molecular Science, Lewis B. and Dorothy Cullman Cancer Center Chemoprotection Center, Johns Hopkins University School of Medicine; Center for Human Nutrition, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205-2185 Jose ´ M. Villalba (13), Departamento de Biologı ´ a Celular, Fisiologı ´ a, e Immunol- gı ´ a, Campus Rabanales, Universidad de Co ´ rdoba, 14014 Co ´ rdoba, Spain Nobunao Wakabayashi (22), Department of Environmental Health Sciences, School of Public Health, Johns Hopkins Univer- sity Bloomberg, Baltimore, Maryland 21205 Timothy H. Ward (10), Drug Develop- ment Unit, Paterson Institute, Christie Hospital, Manchester M20 9BX, United Kingdom John X. Wilson (6), Department of Phy- siology, University of Western Ontario, London, Ontario N6A 5C1, Canada xiv contributors to volume 382 Preface Developments in genomics and proteomics rapidly generated focus on new -omics, particularly metabolomics and phenomics. Quinones, hydroquinones, semiquinones and their metabolites are naturally occurring compounds that serve as wonderful examples for this new paradigm of interdigitating ,-omics.In addition to a role as substrates and products in metabolism, quinone com- pounds are intermediates in many pathways of gene regulation, enzyme protein induction, feedback control, and waste product elimination. Quinones play a pivotal role in energy metabolism (Peter Mitchell’s proton-motive, Q cycle’), many other key processes, and even in chemotherapy where redox cycling drugs are utilized. The present volume of Methods in Enzymology on quinones and quinone enzymes serves to bring together current methods and concepts on this topic. It focuses on the role in the so-called Phase II of drug metabolism (xenobiotics), but include aspects on Phase I (CYP, cytochromes P-450) and Phase III (transport systems) as well. This volume of Methods in Enzymology, Part B addresses mitochondrial ubiquinone and reductases, anticancer quinones, and the role of quinone reductases in chemoprevention and nutrition, as well as the role of quinones in age-related diseases, whereas (Part A) focused on quinones and quinone enzymes in terms of coenzyme Q (detection and quinone reduc- tases), plasma membrane quinone reductases, and the role of quinones in cellular signaling and modulation of gene expression. Phase II Enzymes, Part C, will be focusing on glutathione, glutathione S-transferases, and other conjugation enzymes. The enzyme, NAD(P)H:quinone oxidoreductase, is the subject of a major section in this volume. This enzyme, discovered in 1958 in Stockholm by Lars Ernster, and named DT-Diaphorase by him, has multiple roles, some of which were only recently discovered. Human polymorphisms exist in these enzymes that relate to variations in cancer risk, and enzymes targeted by quinones are being investigated. Modern methods in assaying quinone reactions and, indeed, various quinones themselves, are also included in this volume. Following its discovery in 1957, ubiquinone (coenzyme Q 10 ) as a major naturally occurring quinone became a highlight of scientific interest and an established role in mitochondrial electron transport by Frederick Crane. Fundamental contributions were made by Karl Folkers on its supplemental xv use for health benefits in disease prevention and by Andre ´ s O.M. Stoppani, a pioneer of Argentinian biochemistry, in utilizing quinones for the treatment of Chagas disease. We thank the Advisory Committee (Enrique Cadenas, Los Angeles; Gustav Dallner, Stockholm; Tom Kensler, Baltimore; Lars-Oliver Klotz, Du ¨ sseldorf; David Ross, Denver) for their valuable suggestions and wisdom in selecting the contributions for this volume. Helmut Sies and Lester Packer xvi preface METHODS IN ENZYMOLOGY Volume I. Preparation and Assay of Enzymes Edited by Sidney P. Colowick and Nathan O. Kaplan Volume II. Preparation and Assay of Enzymes Edited by Sidney P. Colowick and Nathan O. Kaplan Volume III. Preparation and Assay of Substrates Edited by Sidney P. Colowick and Nathan O. Kaplan Volume IV. Special Techniques for the Enzymologist Edited by Sidney P. Colowick and Nathan O. Kaplan Volume V. Preparation and Assay of Enzymes Edited by Sidney P. Colowick and Nathan O. Kaplan Volume VI. Preparation and Assay of Enzymes (Continued) Preparation and Assay of Substrates Special Techniques Edited by Sidney P. Colowick and Nathan O. Kaplan Volume VII. Cumulative Subject Index Edited by Sidney P. Colowick and Nathan O. Kaplan Volume VIII. Complex Carbohydrates Edited by Elizabeth F. Neufeld and Victor Ginsburg Volume IX. Carbohydrate Metabolism Edited by Willis A. Wood Volume X. Oxidation and Phosphorylation Edited by Ronald W. Estabrook and Maynard E. Pullman Volume XI. Enzyme Structure Edited by C. H. W. Hirs Volume XII. Nucleic Acids (Parts A and B) Edited by Lawrence Grossman and Kivie Moldave Volume XIII. Citric Acid Cycle Edited by J. M. Lowenstein Volume XIV. Lipids Edited by J. M. Lowenstein Volume XV. Steroids and Terpenoids Edited by Raymond B. Clayton xvii Volume XVI. Fast Reactions Edited by Kenneth Kustin Volume XVII. Metabolism of Amino Acids and Amines (Parts A and B) Edited by Herbert Tabor and Celia White Tabor Volume XVIII. Vitamins and Coenzymes (Parts A, B, and C) Edited by Donald B. McCormick and Lemuel D. Wright Volume XIX. Proteolytic Enzymes Edited by Gertrude E. Perlmann and Laszlo Lorand Volume XX. Nucleic Acids and Protein Synthesis (Part C) Edited by Kivie Moldave and Lawrence Grossman Volume XXI. Nucleic Acids (Part D) Edited by Lawrence Grossman and Kivie Moldave Volume XXII. Enzyme Purification and Related Techniques Edited by William B. Jakoby Volume XXIII. Photosynthesis (Part A) Edited by Anthony San Pietro Volume XXIV. Photosynthesis and Nitrogen Fixation (Part B) Edited by Anthony San Pietro Volume XXV. Enzyme Structure (Part B) Edited by C. H. W. Hirs and Serge N. Timasheff Volume XXVI. Enzyme Structure (Part C) Edited by C. H. W. Hirs and Serge N. Timasheff Volume XXVII. Enzyme Structure (Part D) Edited by C. H. W. Hirs and Serge N. Timasheff Volume XXVIII. Complex Carbohydrates (Part B) Edited by Victor Ginsburg Volume XXIX. Nucleic Acids and Protein Synthesis (Part E) Edited by Lawrence Grossman and Kivie Moldave Volume XXX. Nucleic Acids and Protein Synthesis (Part F) Edited by Kivie Moldave and Lawrence Grossman Volume XXXI. Biomembranes (Part A) Edited by Sidney Fleischer and Lester Packer Volume XXXII. Biomembranes (Part B) Edited by Sidney Fleischer and Lester Packer Volume XXXIII. Cumulative Subject Index Volumes I-XXX Edited by Martha G. Dennis and Edward A. Dennis Volume XXXIV. Affinity Techniques (Enzyme Purification: Part B) Edited by William B. Jakoby and Meir Wilchek xviii methods in enzymology Volume XXXV. Lipids (Part B) Edited by John M. Lowenstein Volume XXXVI. Hormone Action (Part A: Steroid Hormones) Edited by Bert W. O’Malley and Joel G. Hardman Volume XXXVII. Hormone Action (Part B: Peptide Hormones) Edited by Bert W. O’Malley and Joel G. Hardman Volume XXXVIII. Hormone Action (Part C: Cyclic Nucleotides) Edited by Joel G. Hardman and Bert W. O’Malley Volume XXXIX. Hormone Action (Part D: Isolated Cells, Tissues, and Organ Systems) Edited by Joel G. Hardman and Bert W. O’Malley Volume XL. Hormone Action (Part E: Nuclear Structure and Function) Edited by Bert W. O’Malley and Joel G. Hardman Volume XLI. Carbohydrate Metabolism (Part B) Edited by W. A. Wood Volume XLII. Carbohydrate Metabolism (Part C) Edited by W. A. Wood Volume XLIII. Antibiotics Edited by John H. Hash Volume XLIV. Immobilized Enzymes Edited by Klaus Mosbach Volume XLV. Proteolytic Enzymes (Part B) Edited by Laszlo Lorand Volume XLVI. Affinity Labeling Edited by William B. Jakoby and Meir Wilchek Volume XLVII. Enzyme Structure (Part E) Edited by C. H. W. Hirs and Serge N. Timasheff Volume XLVIII. Enzyme Structure (Part F) Edited by C. H. W. Hirs and Serge N. Timasheff Volume XLIX. Enzyme Structure (Part G) Edited by C. H. W. Hirs and Serge N. Timasheff Volume L. Complex Carbohydrates (Part C) Edited by Victor Ginsburg Volume LI. Purine and Pyrimidine Nucleotide Metabolism Edited by Patricia A. Hoffee and Mary Ellen Jones Volume LII. Biomembranes (Part C: Biological Oxidations) Edited by Sidney Fleischer and Lester Packer Volume LIII. Biomembranes (Part D: Biological Oxidations) Edited by Sidney Fleischer and Lester Packer methods in enzymology xix [...]... Cumulative Subject Index Volumes 61–74, 76–80 Edited by Edward A Dennis and < /b> Martha G Dennis Volume 96 Biomembranes [Part < /b> J: Membrane Biogenesis: Assembly and < /b> Targeting (General Methods; Eukaryotes)] Edited by Sidney Fleischer and < /b> Becca Fleischer Volume 97 Biomembranes [Part < /b> K: Membrane Biogenesis: Assembly and < /b> Targeting (Prokaryotes, Mitochondria, and < /b> Chloroplasts)] Edited by Sidney Fleischer and < /b> Becca Fleischer... LIV Biomembranes (Part < /b> E: Biological Oxidations) Edited by Sidney Fleischer and < /b> Lester Packer Volume LV Biomembranes (Part < /b> F: Bioenergetics) Edited by Sidney Fleischer and < /b> Lester Packer Volume LVI Biomembranes (Part < /b> G: Bioenergetics) Edited by Sidney Fleischer and < /b> Lester Packer Volume LVII Bioluminescence and < /b> Chemiluminescence Edited by Marlene A DeLuca Volume LVIII Cell Culture Edited by William B Jakoby... Di Sabato and < /b> Johannes Everse Volume 133 Bioluminescence and < /b> Chemiluminescence (Part < /b> B) Edited by Marlene DeLuca and < /b> William D McElroy Volume 134 Structural and < /b> Contractile Proteins (Part < /b> C: The Contractile Apparatus and < /b> the Cytoskeleton) Edited by Richard B Vallee Volume 135 Immobilized Enzymes and < /b> Cells (Part < /b> B) Edited by Klaus Mosbach Volume 136 Immobilized Enzymes and < /b> Cells (Part < /b> C) Edited by Klaus... Fleischer Volume 98 Biomembranes (Part < /b> L: Membrane Biogenesis: Processing and < /b> Recycling) Edited by Sidney Fleischer and < /b> Becca Fleischer Volume 99 Hormone Action (Part < /b> F: Protein Kinases) Edited by Jackie D Corbin and < /b> Joel G Hardman Volume 100 Recombinant DNA (Part < /b> B) Edited by Ray Wu, Lawrence Grossman, and < /b> Kivie Moldave Volume 101 Recombinant DNA (Part < /b> C) Edited by Ray Wu, Lawrence Grossman, and < /b> Kivie Moldave... Edited by Leon W Cunningham Volume 146 Peptide Growth Factors (Part < /b> A) Edited by David Barnes and < /b> David A Sirbasku Volume 147 Peptide Growth Factors (Part < /b> B) Edited by David Barnes and < /b> David A Sirbasku Volume 148 Plant Cell Membranes Edited by Lester Packer and < /b> Roland Douce Volume 149 Drug and < /b> Enzyme Targeting (Part < /b> B) Edited by Ralph Green and < /b> Kenneth J Widder Volume 150 Immunochemical Techniques (Part.< /b> .. Recombinant DNA (Part < /b> F) Edited by Ray Wu Volume 156 Biomembranes (Part < /b> P: ATP-Driven Pumps and < /b> Related Transport: The Na, K-Pump) Edited by Sidney Fleischer and < /b> Becca Fleischer Volume 157 Biomembranes (Part < /b> Q: ATP-Driven Pumps and < /b> Related Transport: Calcium, Proton, and < /b> Potassium Pumps) Edited by Sidney Fleischer and < /b> Becca Fleischer Volume 158 Metalloproteins (Part < /b> A) Edited by James F Riordan and < /b> Bert... Interactions Edited by Jonathan B Chaires and < /b> Michael J Waring Volume 341 Ribonucleases (Part < /b> A) Edited by Allen W Nicholson Volume 342 Ribonucleases (Part < /b> B) Edited by Allen W Nicholson Volume 343 G Protein Pathways (Part < /b> A: Receptors) Edited by Ravi Iyengar and < /b> John D Hildebrandt Volume 344 G Protein Pathways (Part < /b> B: G Proteins and < /b> Their Regulators) Edited by Ravi Iyengar and < /b> John D Hildebrandt Volume 345... Biological Macromolecules (Part < /b> E) Edited by Jo M Holt, Michael L Johnson, and < /b> Gary K Ackers Volume 381 Oxygen Sensing (in preparation) Edited by Chandan K Sen and < /b> Gregg L Semenza Volume 382 Quinones < /b> and < /b> Quinone < /b> Enzymes (Part < /b> B) Edited by Helmut Sies and < /b> Lester Packer Volume 383 Numerical Computer Methods (Part < /b> D) Edited by Ludwig Brand and < /b> Michael L Johnson Volume 384 Numerical Computer Methods (Part.< /b> .. Fleischer and < /b> Becca Fleischer Volume 126 Biomembranes (Part < /b> N: Transport in Bacteria, Mitochondria, and < /b> Chloroplasts: Protonmotive Force) Edited by Sidney Fleischer and < /b> Becca Fleischer Volume 127 Biomembranes (Part < /b> O: Protons and < /b> Water: Structure and < /b> Translocation) Edited by Lester Packer Volume 128 Plasma Lipoproteins (Part < /b> A: Preparation, Structure, and < /b> Molecular Biology) Edited by Jere P Segrest and < /b> John... Edited by P Michael Conn Volume 169 Platelets: Receptors, Adhesion, Secretion (Part < /b> A) Edited by Jacek Hawiger Volume 170 Nucleosomes Edited by Paul M Wassarman and < /b> Roger D Kornberg Volume 171 Biomembranes (Part < /b> R: Transport Theory: Cells and < /b> Model Membranes) Edited by Sidney Fleischer and < /b> Becca Fleischer Volume 172 Biomembranes (Part < /b> S: Transport: Membrane Isolation and < /b> Characterization) Edited by Sidney . Reactions Edited by Kenneth Kustin Volume XVII. Metabolism of Amino Acids and Amines (Parts A and B) Edited by Herbert Tabor and Celia White Tabor Volume XVIII. Vitamins and Coenzymes (Parts A, B, and C) Edited. 97. Biomembranes [Part K: Membrane Biogenesis: Assembly and Targeting (Prokaryotes, Mitochondria, and Chloroplasts)] Edited by Sidney Fleischer and Becca Fleischer Volume 98. Biomembranes (Part. Enzymes and Cells (Part C) Edited by Klaus Mosbach Volume 137. Immobilized Enzymes and Cells (Part D) Edited by Klaus Mosbach Volume 138. Complex Carbohydrates (Part E) Edited by Victor Ginsburg Volume