cole - analysis of controlled substances (wiley, 2003)

[...]... substances However, it is sometimes necessary for the analyst to determine the amount as well as the Table 1.1 Principle sections of the Misuse of Drugs Act, 1971 and corresponding offences Section of the Misuse of Drugs Act, 1971 3 4 5 6 8 9 9 20 † May, 2002 Type of offence which is controlled Importation and exportation of controlled drugs Production and supply of controlled drugs Possession of controlled. .. 137 x Analysis of Controlled Substances 9 The Analysis of Controlled Pharmaceutical Drugs – Barbiturates and Benzodiazepines 9.1 Introduction 9.2 Analysis of Barbiturates and Benzodiazepines 9.2.1 Extraction of Barbiturates and Benzodiazepines from Dose Forms 9.2.2 Presumptive Tests for Barbiturates and Benzodiazepines 9.2.3 TLC of Barbiturates and Benzodiazepines 9.2.4 Confirmatory Analysis of Barbiturates... Introduction 7.2 Products of Catha edulis 7.2.1 Identification, Quantification and Comparison of Khat Samples 7.2.2 Comparison of Khat Samples 7.3 Products of Lophophora williamsii 7.3.1 Physical Description and Sampling of Materials 7.3.2 Presumptive Tests for Mescaline 7.3.3 TLC Analysis of Mescaline 7.3.4 HPLC Analysis of Mescaline 7.3.5 GC–MS Analysis of Mescaline 7.3.6 Comparison of Peyote Samples References... Remarks The problems associated with psychotropic drugs and controlled substances have been, and continue to be, the subject of much debate Regardless of one’s views, however, there remains the fact that a number of drugs are controlled substances There is now a considerable body of evidence that the number of people using controlled substances for non-medical purposes is increasing Data from the United Kingdom... 124 125 The Analysis of Psilocybin and Psilocin from Fungi 127 8.1 Introduction 8.2 Identification of Psilocybin- and Psilocin-Containing Mushrooms 8.2.1 Identification of Fungal Species from Morphological Characteristics 8.2.2 Identification of Psilocin and Psilocybin Using Chemical Analysis 8.2.3 Quantification of Psilocin and Psilocybin by HPLC 8.3 The Identification of Psilocybin- and Psilocin-Containing...viii Analysis of Controlled Substances 2.3 Quantification of Amphetamines 2.4 Comparison and Profiling of Amphetamine Samples 2.4.1 The Leuckart Synthesis of Amphetamine 2.4.2 The Reductive Amination of Benzyl Methyl Ketone 2.4.3 The Nitrostyrene Synthesis 2.4.4 Impurity Extraction and Sample Comparison References 3 The Analysis of LSD 3.1 Introduction 3.2 Qualitative Identification of LSD 3.2.1... correct analysis and achieve quality data of a certain standard, interpret 6 Analysis of Controlled Substances Table 1.2 Federal scheduling of controlled substances in the United States of America Schedule I II III IV V Examples Potential for abuse Acceptance or otherwise for medical use Safety of drug under medical supervision Lysergic acid diethylamide (LSD), 3,4-methylenedioxymethylamphetamine (MDMA),... and the identification of some fungi However, for other case types a full and rigorous investigation must be undertaken 1.4 Controlled Substances in the United States At the Federal level, controlled substances are listed within a system of five schedules in the Controlled Substances Act These Schedules are described in Table 1.2 Schedule I contains the most strongly controlled substances, while Schedule... time providing full and detailed discussions of the fundamental concepts and theories of the particular analytical method being considered Such books will cover a variety of techniques, including general instrumental analysis, spectroscopy, chromatography, electrophoresis, tandem techniques, xii Analysis of Controlled Substances electroanalytical methods, X-ray analysis and other significant topics In addition,... equipment quality assurance selected-ion monitoring solid-phase extraction total ion current thin layer chromatography United Nations Drug Control Programme ultraviolet df Mr film thickness (of chromatography column) relative molecular weight xvi Analysis of Controlled Substances m/z R R2 Rf tR mass-to-charge ratio correlation coefficient coefficient of determination retardation factor (or relative front . diethylamide MDA 3,4-methylenedioxyamphetamine MDEA 3,4-methylenedioxyethylamphetamine MDMA 3,4-methylenedioxymethylamphetamine MSTFA N-methyl-N -( trimethylsilyl )-2 ,2,2-trifluoroacetamide N,O-BSA N,O-bis(trimethylsilyl)acetamide ODS. available in electronic books. Library of Congress Cataloging-in-Publication Data Cole, M.D.(MichaelD.) The analysis of controlled substances / Michael D. Cole. p. cm. – (Analytical techniques. 136 References 137 x Analysis of Controlled Substances 9 The Analysis of Controlled Pharmaceutical Drugs – Barbiturates and Benzodiazepines 139 9.1 Introduction 139 9.2 Analysis of Barbiturates and