luebke - immunotoxicology and immunopharmacology 3e (crc, 2007)

[...]... Occupational Safety and Health Centers for Disease Control and Prevention Morgantown, WV 26505 Jack P Uetrecht, M.D., Ph.D Faculties of Pharmacy and Medicine Drug Safety Research Group University of Toronto and Sunnybrook Health Science Centre Toronto, Canada Luebke_ 3790_C000.indd xxiv 11/17/2006 2:43:22 PM Part I Immunotoxicology and Hazard Identification Luebke_ 3790_P001.indd 1 10/27/2006 3:43:59 PM Luebke_ 3790_P001.indd... 3:44:04 PM 1 Immunotoxicology: Thirty Years and Counting Robert V House and Robert W Luebke CONTENTS Introduction 4 Origins and Progress in Immunotoxicity Testing 5 The Tier-Testing Approach: Setting the Course for Modern Immunotoxicology 5 Use of Tier-Testing for Industrial and Environmental... assessment is limited to T-dependent antibody response (TDAR), natural killer (NK) cell function, and quantitation of T- and B-cells The current (2006) version of the 7800 Immunotoxicity Guidelines calls for testing in mice and rats, unless data are available to show that absorption, distribution, metabolism and excretion are the same in both species Although mandated for FIFRA and TSCA compounds, the... Immunotoxicity [22], describing immunotoxicology testing for EPA-regulated, non-biochemical agents that fall under the regulatory requirements of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) (7 U.S.C 136 et seq.) and the Toxic Substances Control Act (TSCA) (15 U.S.C 2601) The testing approach mandated by 870.7800 reflects the more limited, case-by-case approach currently favored... ThyagaRajan, Amanda K Damjanovic, Brooke Millar, Cheri Lubahn, and Dianne Lorton Chapter 29 Stress, Immune Function, and Resistance to Disease: Human and Rodent Models 509 Eric V Yang and Ronald Glaser Chapter 30 Recreational Drugs, Immune Function, and Resistance to Infection 527 Herman Friedman, Susan Pross, and Thomas W Klein PART IX Allergy and Hypersensitivity... of Preclinical Safety Evaluation of Biotechnology-Derived Pharmaceuticals Luebke_ 3790_C001.indd 9 10/24/2006 3:16:46 PM 10 Immunotoxicology and Immunopharmacology S6 [53] This document includes sections on immunogenicity as well as a brief section on immunotoxicity evaluation Notably, the use of a standard tier approach was rejected in favor of case-by-case screening, followed by mechanistic studies... University of Texas MD Anderson Cancer Center 7455 Fannin St; Box 301402-Unit 902 Houston, TX 77030 Ralph J Smialowicz, Ph.D Immunotoxicology Branch National Health and Environmental Effects Research Laboratory Environmental Protection Agency Research Triangle Park, NC 27711 Michael R Woolhiser, Ph.D The Dow Chemical Company Toxicology and Environmental Research and Consulting Midland, MI 48674 James... “Environmental Immunology.” For example, chapters have been added that describe the role of immune mediators in liver, lung, and skin toxicity, in regulating drug- and chemical-metabolizing enzymes and in the immunosuppression produced by ultraviolet light, as well as immunotoxicology studies of non-mammalian systems More emphasis has been placed upon the clinical consequences of immunotoxicity as well as on the... human and animal test systems, and risk assessment This is followed by chapters discussing various environmental agents, therapeutic drugs, biological agents, and drugs of abuse as well as immune-mediated toxicity that occur in specific organ systems The second section is devoted to autoimmunity and includes discussions on the immunopathogenesis of autoimmunity as well as examples of chemical- and druginduced... chronological approach since progress in all aspects of immunotoxicology has not been linear Luebke_ 3790_C001.indd 4 10/24/2006 3:16:45 PM Immunotoxicology 5 ORIGINS AND PROGRESS IN IMMUNOTOXICITY TESTING THE TIER-TESTING APPROACH: SETTING THE COURSE FOR MODERN IMMUNOTOXICOLOGY The majority of early publications that can be reasonably identified as comprising immunotoxicology reported altered resistance to . States of America on acid-free paper 10 9 8 7 6 5 4 3 2 1 International Standard Book Number-10: 0-8 49 3-3 79 0-9 (Hardcover) International Standard Book Number-13: 97 8-0 -8 49 3-3 79 0-1 (Hardcover) This. edited by Robert Luebke, Robert House, and Ian Kimber. 3rd ed. p. ; cm. (Target organ toxicology series) Includes bibliographical references and index. ISBN-13: 97 8-0 -8 49 3-3 79 0-1 (hardcover :. lung, and skin toxicity, in regulating drug- and chemical-metabolizing enzymes and in the immunosuppres sion produced by ultra- violet light, as well as immunotoxicology studies of non-mammalian