Hyperthyroid Disorders BS Xa Thị Minh Thúy Hyperthyroidism The Thyroid Gland Thyroid hormone biosynthesis Carriers for Circulating Thyroid Hormones Thyroid hormones are transported by carrier plasma p[.]
Hyperthyroidism The Thyroid Gland Thyroid hormone biosynthesis Carriers for Circulating Thyroid Hormones Thyroid hormones are transported by carrier plasma proteins, > 99% of serum T4 and T3 : Thyroxine-binding globulin (TBG): binds 75% of T4, and has 10-20 times greater affinity for T than T3 Transthyretin (TTR) binds T4, 10 – 15% Albumin carries about 7% of T4 High-density lipoproteins (HDL) transports about Clinserum Endocrinol Metab 2002;87:1217-1222 3% of T4 and aboutJanssen 6% OE, ofetTal.3Jin Thyrotoxicosis vs Hyperthyroidism: What’s the Difference? Cường giáp (Hyperthyroidism) is the condition that occurs due to excessive production of thyroid hormone by the thyroid gland Nhiễm độc giáp (Thyrotoxicosis) is the condition that occurs due to excessive thyroid hormone of any cause and therefore includes hyperthyroidism Some, however, use the terms interchangeably Stan, MN (June 2011) "Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists" Thyroid 21 (6): 593–646 doi:10.1089/thy.2010.0417 Epidemiology • In US: 1.2% (0.5% overt and 0.7% subclinical) • Women : Men = : • Prevalence in older women = – 5% – Toxic multinodular goiter more common in older women – Graves’ more common in younger women National Health and Nutrition Examination Survey (NHANES III) - JCEM 2002;87(2):489-99; ArchIntMed 2007;167(13) Clinical manifestation of thyrotoxicosis Laboratory Diagnosis ... 2002;87:1217-1222 3% of T4 and aboutJanssen 6% OE, ofetTal.3Jin Thyrotoxicosis vs Hyperthyroidism: What’s the Difference? Cường giáp (Hyperthyroidism) is the condition that occurs due to excessive production... excessive thyroid hormone of any cause and therefore includes hyperthyroidism Some, however, use the terms interchangeably Stan, MN (June 2011) "Hyperthyroidism and other causes of thyrotoxicosis: management