Thông tin tài liệu
CURRENT ISSUES AND
FUTURE DIRECTION IN
KIDNEY
TRANSPLANTATION
Edited by Thomas Rath
Current Issues and Future Direction in Kidney Transplantation
http://dx.doi.org/10.5772/45909
Edited by Thomas Rath
Contributors
Farzad Kakaei, Silvio Tucci Jr, Wai Hon Lim, Hung Do Nguyen, Rebecca Williams, Germaine Wong, Bhadran Bose, Jean-
Paul Squifflet, Slawomir Dariusz Szajda, David William Mudge, Kimberley Oliver, Siddharth Sharma, Philippe Saas,
Jamal Bamoulid, Cécile Courivaud, Béatrice Gaugler, Didier Ducloux, Stefan Reuter, Mihai Lucan, Phuong-Thu Pham,
Rashad Hassan Rashad Hassan, Ahmed Akl, Shyam Dheda, Siew Chong, Katrien De Vusser, Rubina Naqvi, Marco
Antonio Ayala-Garcia, Beatriz Gonzalez Yebra, Eduardo Guani Guerra, Éctor Jaime Ramírez Barba, Iris Lee, Mythili
Ghanta, Jeanne Dreier, Raji Jacobs, Abdul Razack Amir, Salwa Sheikh, Rawan Amir, Thomas Rath, Maria Jose Herrero,
Ana Luisa Robles Piedras, Minarda De La O Arciniega, Josefina Reynoso Vázquez
Published by InTech
Janeza Trdine 9, 51000 Rijeka, Croatia
Copyright © 2013 InTech
All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license, which allows users to
download, copy and build upon published articles even for commercial purposes, as long as the author and publisher
are properly credited, which ensures maximum dissemination and a wider impact of our publications. After this work
has been published by InTech, authors have the right to republish it, in whole or part, in any publication of which they
are the author, and to make other personal use of the work. Any republication, referencing or personal use of the
work must explicitly identify the original source.
Notice
Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those
of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published
chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the
use of any materials, instructions, methods or ideas contained in the book.
Publishing Process Manager Danijela Duric
Technical Editor InTech DTP team
Cover InTech Design team
First published February, 2013
Printed in Croatia
A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from orders@intechopen.com
Current Issues and Future Direction in Kidney Transplantation, Edited by Thomas Rath
p. cm.
ISBN 978-953-51-0985-3
free online editions of InTech
Books and Journals can be found at
www.intechopen.com
Contents
Preface IX
Section 1 Diagnostic Methods in Renal Transplantation 1
Chapter 1 Medical Evaluation of the Adult Kidney Transplant
Candidate 3
Phuong-Thu Pham, Son V. Pham, Phuong-Anh Pham and Phuong-
Chi Pham
Chapter 2 Imaging in Kidney Transplantation 25
Valdair Francisco Muglia, Sara Reis Teixeira, Elen Almeida Romão,
Marcelo Ferreira Cassini, Murilo Ferreira de Andrade, Mery Kato,
Maria Estela Papini Nardin and Silvio Tucci Jr
Chapter 3 Utility of Urinary Biomarkers in Kidney Transplant Function
Assessment 61
Alina Kępka, Napoleon Waszkiewicz, Sylwia Chojnowska, Beata
Zalewska-Szajda, Jerzy Robert Ładny, Anna Wasilewska, Krzysztof
Zwierz and Sławomir Dariusz Szajda
Chapter 4 Non-Invasive Diagnosis of Acute Renal Allograft Rejection −
Special Focus on Gamma Scintigraphy and Positron Emission
Tomography 89
Alexander Grabner, Dominik Kentrup, Uta Schnöckel, Michael
Schäfers and Stefan Reuter
Chapter 5 Detection of Antibody-Mediated Rejection in Kidney
Transplantation and the Management of Highly Sensitised
Kidney Transplant Recipients 105
Shyam Dheda, Siew Chong, Rebecca Lucy Williams, Germaine
Wong and Wai Hon Lim
Section 2 Clinical Aspects of Renal Transplantation 133
Chapter 6 Policies and Methods to Enhance the Donation Rates 135
Lucan Mihai, Lucan Valerian Ciprian and Iacob Gheorghiță
Chapter 7 Kidney Transplantation Techniques 167
Farzad Kakaei, Saman Nikeghbalian and Seyed Ali Malekhosseini
Chapter 8 Renal Aging and Kidney Transplantation 185
Katrien De Vusser and Maarten Naesens
Chapter 9 Comparison of Renal Transplantation Outcomes in Patients
After Peritoneal Dialysis and Hemodialysis – A Case Control
Study and Literature Review 193
Thomas Rath and Stephan Ziefle
Chapter 10 Overview of Immunosuppression in Renal
Transplantation 205
M. Ghanta, J. Dreier, R. Jacob and I. Lee
Chapter 11 Hepatitis C Infection in Kidney Transplantion 233
A.A. Amir, R.A. Amir and S.S. Sheikh
Chapter 12 Kidney and Pancreas Transplantation: The History of Surgical
Techniques and Immunosuppression 249
Jean-Paul Squifflet
Chapter 13 Pregnancy Post Transplant 277
Rubina Naqvi
Chapter 14 Practical Pharmacogenetics and Single Nucleotide
Polymorphisms (SNPs) in Renal Transplantation 287
María José Herrero, Virginia Bosó, Luis Rojas, Sergio Bea, Jaime
Sánchez Plumed, Julio Hernández, Jose Luis Poveda and Salvador F.
Aliño
Chapter 15 Clinical Pharmacology and Therapeutic Drug Monitoring of
Immunosuppressive Agents 309
Ana Luisa Robles Piedras, Minarda De la O Arciniega and Josefina
Reynoso Vázquez
ContentsVI
Section 3 Advances in Transplantation Immunology 343
Chapter 16 The Evolution of HLA-Matching in Kidney
Transplantation 345
Hung Do Nguyen, Rebecca Lucy Williams, Germaine Wong and Wai
Hon Lim
Chapter 17 Transplantation Antigens and Histocompatibility
Matching 371
Bhadran Bose, David W. Johnson and Scott B. Campbell
Chapter 18 CD4 T Lymphopenia, Thymic Function, Homeostatic
Proliferation and Late Complications Associated with Kidney
Transplantation 391
Philippe Saas, Jamal Bamoulid, Cecile Courivaud, Jean-Michel
Rebibou, Beatrice Gaugler and Didier Ducloux
Chapter 19 Current and Future Directions in Antibody-Mediated Rejection
Post Kidney Transplantation 417
Rashad Hassan and Ahmed Akl
Chapter 20 Advances in Antibody Mediated Rejection 445
Siddharth Sharma, Kimberley Oliver and David W Mudge
Chapter 21 Tolerance in Renal Transplantation 463
Marco Antonio Ayala-García, Beatriz González Yebra, Éctor Jaime
Ramirez Barba and Eduardo Guaní Guerra
Contents VII
Preface
Renal transplantation is the treatment of choice for patients with end-stage renal disease and
until now half a million renal transplants are done by surgeons, nephrologists, immunolo‐
gists, nurses and patients.
This open-access book covers diagnostic methods as well as clinical aspects and advances in
transplantation immunology. The area covered spans from imaging methods, impact of do‐
nor factors, clinical comorbidities to recent developments in HLA-Matching and Antibody-
Mediated rejection.
The authors are all experienced clinicians and scientists from different regions of the world.
So, this book may help us all by giving useful information to improve care for our patients.
Dr. med. Thomas Rath
Department of Nephrology and Transplantation Medicine
Westpfalz-Klinikum, Kaiserslautern, Germany
[...]... indications Intractable hypertension2 Acquired renal cystic disease3 Indicated for massively enlarged kidneys, recurrently infected or bleeding, intractable pain 1 Should be individualized 2 When there is suspicion for adenocarcinoma 3 Table 6 Indications for pretransplant native nephrectomy 17 18 Current Issues and Future Direction in Kidney Transplantation 3 Evaluation of risk factors related to specific... reassess their candidacy Most transplant programs attempt to see transplant candidates on an annual basis to update their overall heatlh and demographic issues although older candidates may require more frequent visits at the discretion of the transplant physician During the follow-up visit, routine health maintenance status and cancer screening 19 20 Current Issues and Future Direction in Kidney Transplantation. .. reproduction in any medium, provided the original work is properly cited 4 Current Issues and Future Direction in Kidney Transplantation Absolute contraindications Active malignancy Active infection Severe irreversible extrarenal disease Life expectancy < 2 years Liver cirrhosis1 (unless combined liver and kidney transplant) Primary oxalosis (unless combined liver and kidney transplant) Limited, irremediable... problems facing transplant centers Periodic reassessment of transplant candidates’ medical and psychosocial issues entails ongoing communication between the dialysis units, patients, and transplant coordinators and transplant programs In the event of a significant intercurrent illness that may necessitate delisting or placing candidates on hold, pertinent medical records should be obtained and reviewed... III; Level of Evidence B) (Lentine et al., 2012) In patients with established CVD or in those at risk for CV events, aggressive risk factor modification and treatment per ACC/AHA guidelines (Pearson et al., 2002) are recommended The cardioprotective effects of statins, aspirin, ACE inhibitors, and/ or β blockers have been 9 10 Current Issues and Future Direction in Kidney Transplantation Figure 1 Suggested... advised against transplantation Table 5 Malignancy and renal transplantation1 ,2 15 16 Current Issues and Future Direction in Kidney Transplantation 2.7 Specific gastrointestinal evaluation There has been no consensus on whether all asymptomatic renal transplant candidates should be screened for cholelithiasis Screening is warranted, however, in diabetics and patients with a history of cholecystitis Pretransplant... physicians Screening for covert cardiovascular disease and occult malignancy, and careful assessment of infectious risk in older prospective transplant candi‐ dates are crucial and mandatory Currently, the waiting time for a deceased donor transplant in the United States is such that many wait-listed older transplant candidates die while awaiting transplantation from a standard deceased donor kidney Furthermore,... re-addressed Currently, in an effort to maximize the utilization of living kidney donors, our program has implemented an algorithm to evaluate crossmatch positive and ABO-incompatible donor-recipient pairs Patients are advised of living donor options including paired exchange transplantation, positive crossmatch and ABO incompatible transplantation through desensitization protocols, and living donor kidney. .. reactivation and replication and progression of liver disease Similar to HBV infection, liver biopsy is essential in the evaluation of transplant candidate with HCV because clinical and biochemical findings are unreliable indicators of the severity of liver disease in the dialysis population The presence of minimal to mild chronic hepatitis (stages I and II) does not preclude transplantation Pretransplantation... C (HCV) cirrhosis and hepatic portal venous gradient (HPVG) of less than 10 mmHg In a 13 14 Current Issues and Future Direction in Kidney Transplantation single center study consisting of 37 kidney alone HCV positive transplant recipients (n=9 with cirrhosis and n= 28 with no cirrhosis), none developed decompensation of their liver disease at 3-year follow-up although one patient in the non-cirrhosis . CURRENT ISSUES AND FUTURE DIRECTION IN KIDNEY TRANSPLANTATION Edited by Thomas Rath Current Issues and Future Direction in Kidney Transplantation http://dx.doi.org/10.5772/45909 Edited. Grading Current Issues and Future Direction in Kidney Transplantation8 it should also be noted that in ESKD patients both myocardial perfusion study (MPS) and DSE have reduced sensitivity and. these barriers Table 1. Contraindications for renal transplantation Current Issues and Future Direction in Kidney Transplantation4 1.2.2. Psychiatric evaluation Coexisting psychiatric disorders have
Ngày đăng: 29/03/2014, 21:20
Xem thêm: CURRENT ISSUES AND FUTURE DIRECTION IN KIDNEY TRANSPLANTATION ppt, CURRENT ISSUES AND FUTURE DIRECTION IN KIDNEY TRANSPLANTATION ppt, Single photon (gamma) imaging and positron emission tomography, Renal transplantation in PD–patients – first experience, Natural history of HCV infection, morbidity and mortality in transplant, Clinical outcome with impact of HCV status before transplantation, and use of allografts from HCV positive donors, The role of homeostatic proliferation expansion after CD4+ T cell depletion in the complications associated with over-immunosuppression, The role of thymic activity after CD4+ T cell depletion in the complications associated with over-immunosuppression