HYPERPARATHYROIDISM Edited by Gonzalo Díaz-Soto and Manuel Puig-Domingo Hyperparathyroidism Edited by Gonzalo Díaz-Soto and Manuel Puig-Domingo Published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia Copyright © 2012 InTech All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source. As for readers, this license allows users to download, copy and build upon published chapters even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book. Publishing Process Manager Romana Vukelic Technical Editor Teodora Smiljanic Cover Designer InTech Design Team First published April, 2012 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from orders@intechopen.com Hyperparathyroidism, Edited by Gonzalo Díaz-Soto and Manuel Puig-Domingo p. cm. ISBN 978-953-51-0478-0 Contents Preface IX Part 1 New Trends in Medical Monitoring of Hyperparathyroidism 1 Chapter 1 Normocalcemic Primary Hyperparathyroidism 3 Maria-Teresa Julián, Izaskun Olaizola, Gonzalo Díaz-Soto and Manuel Puig-Domingo Part 2 New Trends in Surgical Treatment on Hyperparathyroidism 11 Chapter 2 Parathyroid Adenoma Completely Impacted Within the Thyroid: A Case Report and Literature Review 13 Yuko Tanaka, Hisato Hara and Yuzuru Kondo Chapter 3 Minimally Invasive Parathyroidectomy for Primary Hyperparathyroidism – Current Views, Issues and Controversies 21 Ian Yu-Hong Wong and Brian Hung-Hin Lang Chapter 4 Radio-Guided Surgery and Intraoperative iPTH Determination in the Treatment of Primary Hyperparathyroidism 35 Paloma García-Talavera and José Ramón García-Talavera Part 3 Hyperparathyroidism and Dyalisis 57 Chapter 5 Aluminum Overload: An Easily-Ignored Problem in Dialysis Patients with Hyperparathyroidism 59 Wei-Chih Kan, Chih-Chiang Chien, Yi-Hua Lu, Jyh-Chang Hwang, Shih-Bin Su and Hsien-Yi Wang VI Contents Chapter 6 Hyperparathyroidism in Hemodialyzed Patients – Relation to Melatonin and Reproductive Hormones Before and After Parathyroidectomy 67 Radmila Kancheva, Ivana Zofkova, Martin Hill, Sylvie Dusilova-Sulkova, Ludmila Kancheva, Sven Röjdmark, Antonin Parizek, Michaela Duskova, Zoltan Paluch, Veronika Cirmanova and Luboslav Starka Preface Hyperparathyroidism is currently one of the most exciting fields in endocrinology. It is under constant development due to extent of the clinical spectrum of primary hyperparathyroidism. In addition, its relationship with other disorders as secondary/tertiary hyperparathyroidism (mainly in the context of chronic renal failure or haemodialysis) and its complications calls for a particularly complex approach and requires evaluation by many specialists. In the last decade the progress and development of biochemical assays and new imaging techniques has allowed the diagnosis of unsuspected and asymptomatic disease whose therapeutic approach is still in debate (as normocalcemic hyperparathyroidism). Finally, the progress on minimally invasive parathyroidectomy, intraoperative PTH and radio-guided surgery is changing the paradigm in treatment of hyperparathyroidism. All these hot spots in endocrinology are addressed in the book that now we present. This book is the result of the collaboration between worldwide authorities of different specialities and we are grateful to them for the quality of the contributions. The book aims to provide a general but deep view of primary/secondary and tertiary hyperparathyroidism, from a physiological basis to hyperparathyroidism in hemodialyzed patients, as well as new treatment approaches, techniques and surgical scenarios. We hope that the medical and paramedical researchers will find this book helpful and stimulating. We look forward to sharing knowledge of hyperparathyroidism with a wider audience. Professor Dr Manuel Puig-Domingo University Autonoma of Barcelona Medical School, Germans Trias i Pujol, Badalona Spain Dr Gonzalo Díaz-Soto University of Valladolid Medical School, Clinic Hospital, Valladolid Spain . HYPERPARATHYROIDISM Edited by Gonzalo Díaz-Soto and Manuel Puig-Domingo Hyperparathyroidism Edited by Gonzalo Díaz-Soto and. can be obtained from orders@intechopen.com Hyperparathyroidism, Edited by Gonzalo Díaz-Soto and Manuel Puig-Domingo p. cm. ISBN 978-953-51-0478-0