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[...]... THE FIRST 4000 YEARS 5 6 ALTERNATIVE TOXICOLOGICAL METHODS RUSSELL AND BURCH THE THREE Rs THE FIRST 4000 YEARS 7 REFERENCES CHAPTER 2 A History of Interagency Approaches to Alternatives and Establishment of the Interagency Regulatory Alternatives Group CONTENTS INTRODUCTION 9 10 ALTERNATIVE TOXICOLOGICAL METHODS ESTABLISHMENT OF IRAG A HISTORY OF INTERAGENCY APPROACHES TO ALTERNATIVES IRAG WORKSHOPS... Contributors Contents PART I Progress in the Validation and Regulatory Acceptance of Alternatives 2 ALTERNATIVE TOXICOLOGICAL METHODS CHAPTER 1 Historical Developments in the Humane Care and Use of Research Animals: The First 4000 Years CONTENTS BIBLICAL ORIGINS 3 4 ALTERNATIVE TOXICOLOGICAL METHODS Table 1.1 Chronology for the Enactment of Animal Welfare Legislation Year State Year State . y0 w0 h0" alt="" ALTERNATIVE TOXICOLOGICAL METHODS CRC PRESS Boca Raton London New York Washington, D.C. ALTERNATIVE TOXICOLOGICAL METHODS Edited by Harry

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