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Accepted Manuscript Social Economic Costs of Type Diabetes Mellitus in Pediatric patients in Spain: CHRYSTAL Observational Study Julio López-Bastida, Juan Pedro López-Siguero, Juan Oliva-Moreno, Magaly Perez-Nieves, RenataVilloro, Tatiana Dilla, María Merino, Dingfeng Jiang, Isaac Aranda-Reneo, Jesús Reviriego, Luis AlbertoVázquez PII: DOI: Reference: S0168-8227(17)30351-0 http://dx.doi.org/10.1016/j.diabres.2017.02.033 DIAB 6893 To appear in: Diabetes Research and Clinical Practice Received Date: Revised Date: Accepted Date: 29 March 2016 12 January 2017 25 February 2017 Please cite this article as: J López-Bastida, J Pedro López-Siguero, J Oliva-Moreno, M Perez-Nieves, RenataVilloro, T Dilla, M Merino, D Jiang, I Aranda-Reneo, J Reviriego, L AlbertoVázquez, Social Economic Costs of Type Diabetes Mellitus in Pediatric patients in Spain: CHRYSTAL Observational Study, Diabetes Research and Clinical Practice (2017), doi: http://dx.doi.org/10.1016/j.diabres.2017.02.033 This is a PDF file of an unedited manuscript that has been accepted for publication As a service to our customers we are providing this early version of the manuscript The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain TITLE PAGE Social Economic Costs of Type Diabetes Mellitus in Pediatric patients in Spain: CHRYSTAL Observational Study Julio López-Bastida a, Juan Pedro López-Siguero b, Juan Oliva-Moreno c, Magaly Perez-Nieves d, RenataVilloro e, Tatiana Dilla f, María Merino e, Dingfeng Jiang d, Isaac Aranda-Reneo g, Jesús Reviriego f, Luis AlbertoVázquez h a University of Castilla-La Mancha, Avda Real Fábrica de Seda, s/n, 45600, Talavera de la Reina, Toledo, Spain b Pediatric Endocrinology Department, Regional University Hospital, Avda Arroyo de los Ángeles s/n 29011, Málaga, Spain c Department of Economics and Finance, University of Castilla-La Mancha, Cobertizo de San Pedro Mártir s/n 45071 Toledo, Spain d Eli Lilly and Company, Lilly Corporate Center Indianapolis, IN 46285, USA e Instituto Max Weber, Calle Norias 123, 28221 Majadahonda (Madrid), Spain f Eli Lilly and Company, Avda de la Industria 30, 28108, Alcobendas (Madrid), Spain g Department of Economics and Finance, University of Castilla-La Mancha, Avda Real Fábrica de Seda, s/n, 45600, Talavera de la Reina, Toledo, Spain h Department of Endocrinology, Marqués de Valdecilla University Hospital, Avda Valdecilla, 39008 Santander, Spain Corresponding author: Julio López-Bastida Telephone number: +34 902 204 100 Ext 5675 e-mail address: julio.lopezbastida@uclm.es STRUCTURED ABSTRACT Aims To estimate the social-economic costs of Type Diabetes Mellitus (T1DM) in patients aged 0–17 years in Spain from a social perspective Methods We conducted a cross-sectional observational study in 2014 of 275 T1DM pediatric outpatients distributed across 12 public health centers in Spain Data on demographic and clinical characteristics, healthcare utilization and informal care were collected from medical records and questionnaires completed by clinicians and patient´s caregivers Results A valid sample of 249 individuals was analyzed The average annual cost for a T1DM patient was €27,274 Direct healthcare costs were €4,070 and direct nonhealthcare cost were €23,204 Informal (familial) care represented 83% of total cost, followed by medical material (8%), outpatient and primary care visits (3.1%) and insulin (2.1%) Direct healthcare cost per patient statistically differed by glycated haemoglobin (HbA1c) level [mean cost €4,704 in HbA1c ≥7.5% (≥58 mmol/mol) group versus €3,616 in HbA1c
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