screening and identification of five serum proteins as novel potential biomarkers for cured pulmonary tuberculosis

www.nature.com/scientificreports OPEN received: 30 May 2015 accepted: 29 September 2015 Published: 26 October 2015 Screening and identification of five serum proteins as novel potential biomarkers for cured pulmonary tuberculosis Chong Wang1, Li-Liang Wei2, Li-Ying Shi3, Zhi-Fen Pan4, Xiao-Mei Yu3, Tian-Yu Li1, ChangMing Liu1, Ze-Peng Ping1, Ting-Ting Jiang1, Zhong-Liang Chen1, Lian-Gen Mao1, ZhongJie Li1 & Ji-Cheng Li1 Rapid and efficient methods for the determination of cured tuberculosis (TB) are lacking A total of 85 differentially expressed serum proteins were identified by iTRAQ labeling coupled with twodimensional liquid chromatography-tandem mass spectrometry (2D LC-MS/MS) analysis (fold change >1.50 or