resveratrol regulates neuro inflammation and induces adaptive immunity in alzheimer s disease

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Moussa et al Journal of Neuroinflammation (2017) 14:1 DOI 10.1186/s12974-016-0779-0 RESEARCH Open Access Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease Charbel Moussa1* , Michaeline Hebron1, Xu Huang1, Jaeil Ahn2, Robert A Rissman3, Paul S Aisen4 and R Scott Turner5 Abstract Background: Treatment of mild-moderate Alzheimer’s disease (AD) subjects (N = 119) for 52 weeks with the SIRT1 activator resveratrol (up to g by mouth twice daily) attenuates progressive declines in CSF Aβ40 levels and activities of daily living (ADL) scores Methods: For this retrospective study, we examined banked CSF and plasma samples from a subset of AD subjects with CSF Aβ42

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