Effects of once weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity

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Effects of once-weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects Accepted Article with obesity John Blundell1, Graham Finlayson1, Mads Buhl Axelsen2, Anne Flint2, Catherine Gibbons1, Trine Kvist2, Julie Hjerpsted2 Author affiliations: 1University of Leeds, Leeds, UK; 2Novo Nordisk, Søborg, Denmark Structured abstract Aim: To investigate the mechanism of action for body weight loss with semaglutide Materials and Methods: This randomised, double-blind, placebo-controlled, two-period crossover trial investigated the effects of 12 weeks treatment with once-weekly subcutaneous semaglutide, doseescalated to 1.0 mg, in 30 subjects with obesity Ad libitum energy intake, ratings of appetite, thirst, nausea and well-being, control of eating, food preference, resting metabolic rate, body weight and body composition were assessed This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record Please cite this article as doi: 10.1111/dom.12931 This article is protected by copyright All rights reserved Results: After a standardised breakfast, semaglutide, compared with placebo, led to a lower ad libitum energy intake during lunch (–1255 kJ; Accepted Article P