Clinical characteristics of patients with bone sarcoidosis Author’s Accepted Manuscript Clinical characteristics of patients with bone sarcoidosis Ying Zhou, Elyse E Lower, Huiping Li, Yolanda Farhey,[.]
Author’s Accepted Manuscript Clinical characteristics of patients with bone sarcoidosis Ying Zhou, Elyse E Lower, Huiping Li, Yolanda Farhey, Robert P Baughman www.elsevier.com/locate/semarthrit PII: DOI: Reference: S0049-0172(16)30448-6 http://dx.doi.org/10.1016/j.semarthrit.2017.02.004 YSARH51151 To appear in: Seminars in Arthritis and Rheumatism Cite this article as: Ying Zhou, Elyse E Lower, Huiping Li, Yolanda Farhey and Robert P Baughman, Clinical characteristics of patients with bone sarcoidosis, Seminars in Arthritis and Rheumatism, http://dx.doi.org/10.1016/j.semarthrit.2017.02.004 This is a PDF file of an unedited manuscript that has been accepted for publication As a service to our customers we are providing this early version of the manuscript The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain Clinical characteristics of patients with bone sarcoidosis Ying Zhou1, Elyse E Lower1 Huiping Li2 Yolanda Farhey Robert P Baughman1* Affiliations: Department of Internal Medicine, University of Cincinnati Medical Center, 1001 Holmes, Eden Ave, Cincinnati, OH 45267, USA Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji university School of Medicine, Shanghai 200433, China *Corresponding authors: Robert P Baughman，Department of Internal Medicine, University of Cincinnati Medical Center, 1001 Holmes, Eden Ave, Cincinnati, OH 45267, USA Email: bob.baughman@uc.edu Abstract Objective: To assess the clinical features, diagnosis, and treatment of bone sarcoidosis in the United States Methods: Patients with bone sarcoidosis were identified and matched to sarcoidosis patients based on race, gender, and age Detailed characteristics were obtained by medical record review Results: A total of 64 patients with bone sarcoidosis were enrolled in the study The female: male ratio was 1.46: and the White to Black ratio was 3: Thirtyeight (59.4%) of 64 patients had bone symptoms Compared to matched cases, bone sarcoidosis patients have more multi organ involvement and higher incidence with liver, spleen and extra thoracic lymph node involvement than controls (P 0.05 However, bone sarcoidosis was more common in white patients (P = 0.016) Thirty-eight of 64 (59.4%) of bone involved patients experienced bone symptoms including pain, reduced exercise capacity, numbness or swelling Table summarized the organ involvement for bone sarcoidosis and control patients Thoracic disease was the most commonly involved extra-bone/bone marrow organ reported with 89.1% involvement for bone sarcoidosis patients and 92.2% in controls No patients in the study had identified sarcoidosis muscle involvement The bone involved sarcoidosis patients experienced significantly higher incidence of liver, spleen and extra thoracic lymph node involvement (26.6%, 20.3%, and 29.7% respectively) compared to controls (P