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1338 A Genomic HSV Vector Expressing Human Proenkephalin Reduces Nociceptive Behavior in a Mouse Model of Bone Cancer Pain Molecular Therapy Vol 5, No 5, May 2002, Part 2 of 2 Parts Copyright © The Am[.]
"E! ?'( C D -&8&±;5H/ D*! -&&,±B;H/ !"= -BB8±=;H/ @!%$*' $) '! 1 3 !DD @! -=5",9& / @!%$*' ==:" D4 C D 89# * D4 $) '!%$*' $) '!%!DD%$*' ? 3 @!%$*' C D @!%$*' $) '! 285&6 3 ( !"= C D &9 8:μ# 899μ# &9 T&&9μ# ) $*' $) '! 3 2 2 ( @ @ 1336 Quantitative Comparison of Non-Viral Gene ectors: Model Analysis of Kinetic Intracellular Vectors: Delivery V Trafficking Events Csanad M Varga,1,2 Robert Langer,1,2 Douglas A Lauffenburger.1,2 Division of Biological Engineering; 2Biotechnology Process Engineering Center, Massachusetts Institute of Technology, Cambridge, MA, United States $ E $*' ' " G G 3 ' 0 1 " 3 3 G =' " D '#*> " D" G " -! ,998 !*'(/ #. ! " 1 !@ ' -. ,998 # / 1 3 4 " 3 " 3 S438 "8 "! " ! 1337 Adenoviral Co-Expression of Noggin and BDNF entricular Zone Synergistically Induces Ventricular in the Adult Rat V Neuronal Addition to the Neostriatum Eva J Chmielnicki,1 Abdel Benraiss,1 Aris N Economides,2 Steven A Goldman.1 Neurology and Neuroscience, Cornell University Medical College, NY, NY, United States; 2Regeneron Pharmaceuticals, Tarrytown, NY, United States * G -.N/ 2$*? 3 ' 2$*?-8 #. Δ2, - / 2$*? - #.72$*?7@>(7 ?!/ ' * ' 2$*? ' *%' 2$*? E ( "$ ' #.7 ?! -' * / !2( -M8& = % / ' E 3 -2 4/ 8: 85 8&μ ' *"E 3 8:" J ' * ' *%' 2$*?" E 3 ,&" ' * 4J 3 ' *%' 2$*? "E =&5 ± 8&, 4%β" J %= 69" ' "* E -M998 '*).' ?-,:/M8=,=/ ? ' *%' 2$*?"E 3 ,:" E ' 2$*? -M 998=: '*).' ?-8&/M8;&:/ ' 2$*?%' * "E ? ' 2$*?%' *" 3 '$B; $'@!!"=, C V $ 3 (.N 2$*? " 2$*? 1338 A Genomic HSV V ector Expressing Human Vector Proenkephalin Reduces Nociceptive Behavior in a Mouse Model of Bone Cancer Pain James R Goss,1,3 Cara F Harley,1 Mark E O′Malley,1 Marina Mata,1,3 William F Goins,2 Joseph C Glorioso,2 David J Fink.1,2,3 Neurology, University of Pittsburgh, Pittsburgh, PA, United States; 2Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, PA, United States; 3GRECC, Pittsburgh VA Healthcare System, Pittsburgh, PA, United States > " " 3 " 3 -C(./ 3 ' E 89& * ,6;, =C%C / > β" - (CN/ ! -('!(I 9 M / E ('!(8;±9,, ,B±9, E # (C!> ('!(9,±98, -O99998 (CN/ 89±9= -O9999& (CN/ E @ E E 3 (C!> (CN -,9 ± 9= (C!> ,6 ± 9, (CNI = / (C!> E 3 -8 μ/ ,, ± 9, " 3 1339 Ribozyme-Mediated Striatal Reduction of Huntingtin in Adult Mice Edgardo Rodriguez,1 Lorraine Hamilton,2 Eileen Denovan-Wright,2 Alfred S Lewin,3 Ronald J Mandel.1 Neuroscience, University of Florida College of Medicine, Gainesville, FL, United States; 2Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada; 3Molecular Genetics, University of Florida College of Medicine, Gainesville, FL, United States C -C$/ G -' / 3 &′" C$ C$ =& " " -S/ 3 *" - / S 3 -* / C$ C 1 3 @ ′ " , - ''.,/ @*'" G - G / C$ ( G " @*' A A C$B C$; G C$ 3 8 1 C$8 G 3 8 1 G 1 3 @*' 3 3 8 C$ @*' ( G ? C$; G ''., @>(" ?! 4 ? E , 3 , 8988 4% C$;" ''., -B": / @B% , 3 ?! E " E ' ="& ′ ?!" ''." G " E @*' @*' 1 @ "!@ ) B9 H @*' G C$; G @*' @*' " C$ Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy 1340 Lentiviral V ectors for In V ivo Gene Therapy of Vectors Vivo Metachromatic Leukokystrophy: Study on the Mechanisms Underlying the Therapeutic Effect Antonella Consiglio,1 Diego Dolcetta,1 Tonia Luca,1 Alessandra Biffi,1 Angela Gritti,2 Antonia Follenzi,3 Angelo Vescovi,2 M Grazia Roncarolo,1 Luigi Naldini,3 Claudio Bordignon.1 San Raffaele-Telethon Institute for Gene Therapy, (H.S.R.TIGET), Scientific Institute H San Raffaele, Milan, Italy; 2Stem Cell Research Institute, Scientific Institute H San Raffaele, Milan, Italy; 3Institute for Cancer Research and Treatment, University of Torino, Italy # D -#D$/ G ' -'@('/ G E '@('" ' 3 G #D$ G 1 E 3 - / # G " E E 3 ?! '(,"%" ?! E ?! E E E G ( G #D$ ' % E " G G ?! E ' E 3 3 ?! 3 " ?!" E #D$ # *( S439 ... 1336 Quantitative Comparison of Non-Viral Gene ectors: Model Analysis of Kinetic Intracellular Vectors: Delivery V Trafficking Events Csanad M Varga,1,2 Robert Langer,1,2 Douglas A Lauffenburger.1,2... A Lauffenburger.1,2 Division of Biological Engineering; 2Biotechnology Process Engineering Center, Massachusetts Institute of Technology, Cambridge, MA, United States $