Atypical developmental trajectory of local spontaneous brain activity in autism spectrum disorder 1Scientific RepoRts | 7 39822 | DOI 10 1038/srep39822 www nature com/scientificreports Atypical develo[.]
www.nature.com/scientificreports OPEN received: 16 May 2016 accepted: 28 November 2016 Published: 06 January 2017 Atypical developmental trajectory of local spontaneous brain activity in autism spectrum disorder Xiaonan Guo, Heng Chen, Zhiliang Long, Xujun Duan, Youxue Zhang & Huafu Chen Autism spectrum disorder (ASD) is marked by atypical trajectory of brain maturation, yet the developmental abnormalities in brain function remain unclear The current study examined the effect of age on amplitude of low-frequency fluctuations (ALFF) in ASD and typical controls (TC) using a cross-sectional design We classified all the participants into three age cohorts: child (