1229 control of graft versus host disease using a chimeric suicide gene

1229 Control of Graft Versus Host Disease Using a Chimeric Suicide Gene Molecular Therapy Vol 5, No 5, May 2002, Part 2 of 2 Parts Copyright © The American Society of Gene Therapy S399 ����"��� �"����[.]

" " "                         $                                                                  1                                                    3       1226 The Developmental Potential of a Single Adult Hematopoietic Stem Cell Fernando D Camargo,1 Margaret A Goodell.1 Program in Cell and Molecular Biology and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, United States @                      "     "         3                                             ?      "                              C                                 "  G     G                                   "                                                       -C(/     C    " 3         4                   C(    "              3 -(!/    ("8   $6&       3  99:H           E           "          8&H   "        ?    E   89      3  59H          ,9"                 (                 "       (!                            "                   G                            " " " 1227 Effect of Neutralizing Antibodies on Adenovirus Gene Delivery by the Intravenous Route of Administration: T ranslational Model for Human Immune Translational Response to Adenovirus Van Tsai,1 Amena Rahman,2 Drake LaFace,1 Monica Zepeda,1 Shu Fen Wen,1 Robert Ralston,1 Dan Maneval.1 Canji Inc, San Diego, CA, United States; 2GenStar Therapeutics, San Diego, CA, United States @     - ' /                      C                           G                                 " 3   G       3                     G       '                      G    ($%             "             '       2"  - ' "2/            G             G                      ' "2              E       " 3                      Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy 1228 Characterization and Modulation of the Undesirable T Cell-Mediated Responses to T ransgenes Transgenes Maria-Grazia Roncarolo,1 Megan K Levings,1 Patrizia Mangia,2 Claudio Bordignon,1,2 Sarah Marktel,1 Chiara Bonini,2 Catia Traversari.2,3 San Raffaele Telethon Institute for Gene Therapy, Scientific Institute H San Raffaele, Milan, Italy; 2Cancer Immunotherapy and Gene Therapy Program, Scientific Institute H San Raffaele, Milan, Italy; 3MolMed SpA, Scientific Institute H San Raffaele, Milan, Italy )     E                                                      "                                   )              C(.      - A/      -2#/"                       " "   :,6        A"                               '                                                 "   -    '   D'"6 / '                          "                  D"89      "   "                      $:J   $6J       A                     "               $:"       A       !2D     :      A"    2#"  "       3 $:J                                A"  $:J                   ′                              "   $:J     CD'"             A        '   A"         CD'"2;     A"  $6J            3     G            A        >! )!>     CD'"$@    G         A"  $6J       $6J          A"           6          $6J           A"      \;    A\;                  $6J      A" 3 >2."DD                          D"89     "     A @          D"89       $6J          A"             "    4          D"89   $6J "                 ?*"       A   (  3          $:J              A"            $6J   $:J       D"89                                   1229 Control of Graft-V ersus-Host Disease Using a Graft-Versus-Host Chimeric Suicide Gene Michael P Rettig, Julie K Ritchey, John F DiPersio C    3        -C(."/   "                              " "    -.C$/              4                       "            3   @                     3               $=6 $*'             S399 " " "      C(." $*' -$=6"/                          3   3            - /    $=6"                        $,                 $=6            3       3           -./    .C$ -&99/     -599/2'D2%  -C",  D"&,/             - $/ &;2D%B -6389B   C", D"&8/     -2#/       ,389B   &389&    $=6" A     -  / (           $ 2#     2#      &389&            ,389B         .          89 "  '                   .              .C$ #    .      89"8B   ,9",B 3   "   -B9";9H  8=&/          -69H    8=&/                            .C$   .   "       "      4           -,389B/         .C$        =8               -&389&/               ;;    ="&" ;"  .                     .C$               3                          2#   (       .C$                -&389&/   .  6"89   .C$     .         89 $ 89"8B                   "          "."          '           .C$                    -,389B/        .      6"89   89"8B                   $=6" A 3       .C$   1230 Ex V ransfer into Human L ymphoid Vivo Transfer Lymphoid ivo Gene T Progenitors Results in In Vivo Functionally Mature Transduced T and B Cells Francesca Ficara,1 Alessandro Aiuti,1 Cristina Mocchetti,1 Daniela Superchi,1 Nicole Carballido,2 Sara Deola,1 José Carballido,2 Maria Grazia Roncarolo.1 Telethon Institute for Gene Therapy, Scientific Institute H.S.Raffaele, Milan, Italy; 2Novartis Research Institute, Vienna, Austria D                       2"   "                        -2#/         E                                                                                 2 *A '  ($"                                  2   $=6 J              -42/          ##D.         Δ*?@      D @    -  ;&H   Δ*?@ J  /    (? !) ?D ="      42 $=6J          2   *A      1                 3           B     2   *A        $=6J%=:       42                                    2# $=6J               '   $   -'$'/"   ($              1   2"                              D"=  S400 D";             B     88           2"       1   D";              2# $=6J     '$'"        1       2"       8:                    D"=    1   =&                D";   D"=               2"            1   *A"                           D"=  D";                  3   42 $=6J                 (? !) ?D ="     D";   D"=      ($"   !                 BBH   &9H      D"; D"=         2           $=6J             3                                                                                                            1231 Induction of T Cell T olerance to a MHC Class I Tolerance Alloantigen by Gene Therapy Jessamyn Bagley,1 Chaorui Tian,1 David H Sachs,1 John Iacomini.1 Transplantation Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States ( +(             E            C                      3           #C       ->),? /                                            ) 289'A#   ->),?0-0.4/    "    89,&           "$6 "$:   "$69D                 289'A#              >),? >3   A                G               @     A       3   - D/           289#2@ ->),?-0.4/    )*) )                " 3                                 (" 8J                #C                  3  >) ,?                       3    #     >),?        3  "      >),?              E          (*)+()                   "                                         E  1232 Engraftment of EGFP-Expressing Bone Marrow in Non-Myeloablatively Conditioned Recipients Results in Immunological T olerance towards EGFP-T ransgenic Skin Tolerance EGFP-Transgenic Grafts Goran Andersson,1 Maria Denaro,1 Kevin Johnson,1 Peter Morgan,1 Angela Sullivan,1 David Calderhead,1 Stuart Houser,2 Clive Patience,1 Mary White-Scharf,1 Julian Down.1 Biotransplant Incorporated, Boston, MA, United States; Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA, United States      1                                          3        >          ->?!/      Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy ... Developmental Potential of a Single Adult Hematopoietic Stem Cell Fernando D Camargo,1 Margaret A Goodell.1 Program in Cell and Molecular Biology and Center for Cell and Gene Therapy, Baylor College of. .. Biology and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, United States @                      "     "