514 Transcript Profiling of Adenovirally Transduced Hearts Indicates a Robust Interferon γ Dependent Immune Response Molecular Therapy Vol 5, No 5, May 2002, Part 2 of 2 Parts Copyright © The America[.]
! !"7 " " " ! " E " G 512 Ecdysone Receptor-Based Inducible Gene Regulation Systems for Simultaneous Regulation of T wo Two Genes Subba R Palli, Masha Kapitskaya, Mohan Kumar, Prasanna Kumar, Peter White, Henry Hoff III, Dean E Cress ->@/ G F -@F@/ 3 >@" >@" 1 >@ @F@ *C= = C) >@ " @F@ " ' >@ @F@ 9, # " (™"> #3 ,99 # (™"> >@ ->@/ " (™d> -!'/ # ' # >@ " >@ $ >@ -$>@/ " ' >@-$>?/ D 3'$*' $>@-$>?/ 'D6$*' C @F@"D@F@->?/ !8B &F 'D@>(>'! - &F 'D6 ' ''/ :9!D4 - D 3' ' ''/ *C= = *C= = 3 " (™"> !' ' (™"> (>'! ) !' (>'! ' (™"> !' (>'! >@ 3 Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy 513 In Vivo Selection with a Regulated Cell Growth Switch Allows for a Selective Increase in the Fraction of Erythrocytes Expressing a Linked Gamma-Globin Cassette Following Bone Marrow T ransduction in Mice Transduction David W Emery,1 Julie Tubb,1 Yumiko Nishino,1 Tamon Nishino,1 Kevin G Otto,1 George Stamatoyannopoulos,1 C Anthony Blau.1 Department of Medicine, University of Washington, Seattle, WA, United States 3 3 #(." 3 > ?! -?=B./ G -$/ '!,98:; -* ,B7B6 ,999/ " 3 -C 897:;; 8555/ ( B $" 3 3 > ?! &;H 5BH " ;H::H - M8:/ ' : $ E 8, 6 = -@2/ 3 ?! " $ 3 6 2 $ @2 3 ?! =6" ,&±8,H ;,±,,H -O9998/ @2 3 " 58" 8B±8=H:9±=;H-O9998/' 1 ;" $ @2 3 ?! " ?!" 3 02 8B" - =9±89H6;±8:HM999,/ 6 ' -8B 6 $/ @2 02 3 ?! " @2 3 " =," - =,±,,H M998 " / -M5/ 3 ( $*' $" -,&±95 8&±8, M996/ 5" @2 3 " C @2 3 " 89" 3 > ?! ? 3 514 T ranscript Profiling of Adenovirally T ransduced Transcript Transduced Hearts Indicates a Robust InterferonInterferon-γγ-Dependent Immune Response Stuart A Cook,1 Youngkeun Ahn,1 Takashi Matsui,1 Anthony Rosenzweig.1 CVRC, Massachussettes General Hospital, Charlestown, MA, United States 7 $ E & -' / C ' " - / 3 G 3 ' # 7 @ ' β" ' - "' / ' -' "''/ ,5= 3 , -:9μ 9& 3 898, %/ S169 ! !"7 " " " ! -:9 μ/ E 89 &;2DB -M, / ' ,6 @*' 3 G @*' -4;6' ' 3/ ≥ 89 ' E E 68 -( / @ 7 &= 1 ' ,9 -?*/"γ - 8/ " - '@ /"65 '@ "=5 ' ("8 ' ("8 7 8' ->8'/ ?*"γ" ) >8'" " ?*"γ" Gene Genbank No GARG-49 U43086 GARG-39 U43085 Unknown (15 kDa) X56602 GARG-16 U43084 iGTPase U53219 MIG M34815 Q8/9d D90146 Unknown (like GTPase) U19119 Unknown (GTP binding) L38444 IFN regulatory factor U73037 LMP2 D44456 mGBP-2 AJ007970 Fold Change 224.4 171.3 144.5 132.3 71.7 54.6 44.9 43.9 38.6 31.3 31.1 26.1 IFN-γregulated Yes Yes Yes Yes Yes Yes ? Yes Yes Yes ? Yes mSLFN4 Stat-1 AF099977 24.3 U06924 24.2 ? Yes mSLFN3 IIGP AF099974 24.2 AJ007971 22.9 ? Yes Mx1 M21038 22.5 Yes TAP1-g7 U60020 Unknown (GTP binding) U15635 22.3 19.8 ? Yes MHC H-2K1-k 19.8 Yes M27134 Function Pro-inflammatory Pro-inflammatory Ubiquitin like Pro-inflammatory Macrophage-specific Monokine Transcription factor Proteasome IFN-γ-regulated GTPase T cell development Key regulator of IFN response T cell development IFN-γ-regulated GTPase Influenza virus resistance protein Antigen presentation IFN-induced GTP binding protein 515 Visualization of Prostate Cancer Metastasis in Living Mice by a T argeted Gene T ransfer Adenoviral Targeted Transfer Vector and Optical Imaging Jason Y Adams,1 Makoto Sato,1 Mai Johnson,1 Frank Berger,2 Sanjiv S Gambhir,2 Michael Carey,3 M Luisa Iruela-Arispe,4 Lily Wu.1 Dept.of Urology; 2Medical & Molecular Pharmacology; 3Biological Chemistry, UCLA School of Medicine; 4Molecular Cell and Developmental Biology, College of Letters & Science, UCLA, Los Angeles, CA, United States E 3 " -'/ *" " C " -' !(>"2" / -$/ 3 " -'$/ " -'/ ' !(>"2" 3 !(' 3 ,99999" ' #." " E ) " ' !(>"2" D'!"6 D'!"5 # 3 5" ' '$D'!" S170 6 3 !(' 3 D'!"6 @ =" " E 8:3895 ' !(>"2" ?" " " " 516 Efficient Gene T ransfer and Gene Expression in Transfer Skeletal Muscle Using Improved EIA V Lentivirus V ectors EIAV Vectors John P O′Rourke,1 Hajime Hiraragi,2 John C Olsen,3 Manij Patel,3 Bruce A Bunnell.1,4 Molecular Medicine, Children′s Research Institute, Columbus, Ohio, United States; 2Veterinary Biosciensces, The Ohio State University, Columbus, Ohio, United States; 3Cystic Fibrosis/ Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina, United States; 4Medical Virology, Immunology and Molecular Genetics, The Ohio State University, Columbus, Ohio, United States ( @ 3 C #D. #D. " D " C."8 " 3 C C. " 1 ->'./ 3 >'. " " " -0!@>/ # "! G - >/ 8 -$@/ " @ C."8 >'. 3 > ?! #. - &/ - 89/ ,8, 86 G 3 ,8, C. >'. 8", > ?! G !@ ,8, 3 > ?! :&H",&H >'. 88H C. > ?! 3 ,8, 8H " ,&H >' 0!@> ="& > ?! 3 ,8, > $@ > ?! 3 >'. 3 >'. ' E L8389B B": ?.2%* 2@ # 8 6 8, ′ " G 3 -99&H"6H> ?! / 3 G !@ @ "!@ > ?! 3 >'. 0!@> > ?! 3 >'. ! >'. D @ @ 0!@> >'. 0 3 >'. Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy ... Receptor-Based Inducible Gene Regulation Systems for Simultaneous Regulation of T wo Two Genes Subba R Palli, Masha Kapitskaya, Mohan Kumar, Prasanna Kumar, Peter White, Henry Hoff III, Dean E Cress