413 development of a lacz reporter mouse to evaluate spliceosome mediated RNA trans spicing in vivo

413 Development of a LacZ Reporter Mouse to Evaluate Spliceosome Mediated RNA Trans Spicing In Vivo Molecular Therapy Vol 5, No 5, May 2002, Part 2 of 2 Parts Copyright © The American Society of Gene[.]

REGULA TED GENE EXPRESSION EGULATED 410 Specific Inhibition of bcr-abl Gene Expression by siRNAs in bcr-abl+ Cell Lines Michaela Scherr,1 Karin Battmer,1 Thomas Winkler,1 Olaf Heidenreich,2 Arnold Ganser,1 Matthias Eder.1 Hematology, Hannover Medical School, Hannover, Germany; Molecular Biology, University of Tuebingen, Tuebingen, Germany @*'     -@*'/                                 G      @*'       1  "  "            "   @*' - @*'/             @*'         @*'    $          ,8   =′"   -      @*' @*'/         @*' @*'                                                    '              " @*'       !  -5I,,/-1=6I188/ 3    5&H             -#D/ ,9H      -'DD/   G    ,8"   @*'        =,       1     " @*'                   "      " 1       G  >?!      -=,">?!/ C D               =," >?!     @*'       D*?@    -"        /       "   @*'            G  >?!     D*?@ 3              ,6    "   @*'      "  @*'          >?!J     :9 H            >?!      (  3      =,">?! 3  ,5=               >?!J      &9 H        @*'   "                  "J     A&B, -=," /         "2     2        3  ,89 %   3 "           @*'           3  ;&H      @*'       @*'      1  " @ "!@      A&B,    2   " " @*'   "       3"    " 3          @*'     3     "         41 Catalytic Nucleic Acids for the Specific Inhibition 411 of the Survival Motor Neuron Gene Expression Barbara H Trulzsch,1 Kay Davies,1 Matthew J A Wood.1 Dept of Human Anatomy and Genetics, Oxford, United Kingdom (# ' -(#'/                     (  @$A    (#'                         '   $     1 3                   (                                                                            $     3                       1    @*' - G /   $*' -$*'G /    1             @*'       3      G      $*'G             @*' 1   ' G    $*'G               @*'   1                               @*'              , #                                         Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy                     @*'                              3           412 Inducible Regulation of Endogenous Gene Expression in a Retroviral V ector Delivery System Vector Ya-Li Lee, Xiaohong Zhong, Lei Zhang, S Kaye Spratt Sangamo BioSciences, Inc., Richmond, CA, United States       3             N   $*'      -N?!/    E           $*'   1                     N?!      -N?!" ?/       >?    3       -D   ?             N?!" ? 3               >?     N?!" ?               3                                      N?!" ?         "@>3           "  ##D."        '             ! 3 "               "@>3™",5=   "@>3™"C D $          >? 3   3        "     >3                 3     "      >3      N?!" ?         "@>3™",5=        ,6   6:     6&   899            >? 3        >D(' '        >?   @*'     "@>3"C D      3           >?          >? 3  ' :"     >? 3        ,6                               3                       413 Development of a LacZ Reporter Mouse to Evaluate Spliceosome Mediated RNA T rans-Spicing In Trans-Spicing Vivo Xiaoming Liu,1 Gary S Mansfield,4 M Puttaraju,4 Meihui Luo,1 Lloyd G Mitchell,4 John F Engelhardt.1,2,3 Anatomy and Cell Biology, The University of Iowa, Iowa City, IA, United States; 2Internal Medicine, The University of Iowa, Iowa City, IA, United States; 3The Center for Gene Therapy of Cystic and Other Genetic Diseases, The University of Iowa, Iowa City, IA, United States; 4Intronn LLC, Inc, Rockville, MD, United States (      @*' " -(#@ /                      @*'                             G                         3        @*'    C              3                       (#@        ?&9: ? @       G      -D   *  2  ,99,/   3                                               "                       3      "   "        " "5  ? @               1      "   $*'    3  3        "@*'           #.    S135 REGULA TED GENE EXPRESSION EGULATED 1     =X"DN 3            "        "                            "           ? @  "5    "          " =X" DN 3           "                     DN "      (     "      -! #/              "                      ;                &                   ?8                 DN @*' 3                   '                                  ! #"DN @*' @                                (#@ (  (2@ @66$A&B&,B-D#/  *C   414 A System for Investigating and Optimising Delivery Delivery,, Specificity and Expression of Catalytic Nucleic Acids Louise Everatt,1 Matthew J A Wood.1 Department of Human Anatomy and Genetics, University of Oxford, Oxford, United Kingdom (       G                 @*'    @G                3 G  -$*'G /                   3     @*'    >3             I               G  $*'G                                      3                     1                            3                1                               3        3                              G                       $*'G              ?        3          415 Single Adenovirus V ector Containing Both rtT A Vector rtTA and tTS Expression Cassettes Provides Tight Regulation of T ransgene Expression in a Positive Manner Transgene Hiroyuki Mizuguchi,1 Fuminori Sakurai,1 Takao Hayakawa.1 Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, Tokyo, Japan ?                           3         !            -' /              "      3    -  "     "  /     >8   >=           '     "       3          -2 1  =9 888,"888B ,998 8    2     '            "   3         3  -   B9",&99            /  '            >8       '%@>(% (       >=                    *    '            '    (               '                               416 Ribozyme Mediated Suppression of the Survivin Expression for Cancer Gene Therapy Min Ni,1 Jingde Zhu.1 National Laboratory for Oncogene and Related Genes, Shanghai Cancer Institute, Shanghai, China (        "    3                                                                       G                   @*'                    G         @*'           3        I                 C'          C'    "     @*'                   G           "   @*'                       G                                 " 3           2   "1        @*'                                        G                                                 G   "       417 Ribozyme-T riggered Selective Induction of Ribozyme-Triggered Cytotoxin in Cancer Cells by T argeted T rans-Splicing Targeted Trans-Splicing Byung-Su Kwon,1 Heung-Su Jung,1,2 Sung-Chun Kim,2 Kuchan Kimm,2 Seong-Wook Lee.1,2 Molecular Biology, Dankook University, Seoul, Republic of Korea; 2Genoprot Co., Ltd., Seoul, Republic of Korea  "                      "   3     =′              &′ 3 @*'        " G                                               G       G                         G    "  @*'   G   "       @*' 1               "    G        "           "   @*'     3        3    @*' C               @*'             - >@ /                               3       "                 >@ 3    >@                       C             G               "  3 @*'        "  >@  @*'                       @*'   G          G  '   G  G                @*'                 @ "!@   1          G     Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy ...    @*''   "                  "J     A& B, -=," /         "2     2        3  ,89 %