255 Delivery and Expression of von Willebrand Factor cDNAs Via Hybrid Adenovirus Retrovirus Vectors In Vitro and In Vivo Molecular Therapy Vol 5, No 5, May 2002, Part 2 of 2 Parts Copyright © The Amer[.]
=" " 3 >2. F 3 >2. 1 3 ?F 3 >2. 1 3 253 Encapsulated Primary Myoblasts Deliver Sustained and Therapeutic Levels of Human Factor IX to Hemophilic Mice Jianping Wen,1,2 Frederick A Ofosu,1,2 Gonzalo Hortelano.1,2 Canadian Blood Services; 2Department of Pathology & Molecular Medicine, McMaster University, Hamilton, ON, Canada C 2 ? F -?F/ " ?F ' 0 ?F - ?F/ ,8, -% :;7895&855BI> 8978,:8 8555/ ?F" ' ": - ' @D"86&B/ ?F #? "?F ?F 8&99 %89B % ! ?F &;2D%B -M88/ 89389B -M6/ -M&/ " ": ?F = -L=99%/ LB99% ?F ?F 3 =99% 8,9 ,8, ?F 86 " ?F # ": " ?F -)$ O9,/ E &;2D%B 2 ' 89389B ": ' ?F 6 -L=99%/ L699% ?F &B - 3 / ?F# T8, - " / =; - 65 &B/ 6 & - &;2D%B ,: / ? '! -' ! / 899 - " / :B 6,-'! &9"B9 / ": 2 ? ?F ": ?F ?F" ) 2 S84 254 Hemophilia A Gene Therapy in Mouse and Dog Models Using an AA V-FVIII V ector AAV Vector Linda Couto,1 Haiyan Jiang,1 Ciaran Scallan,1 Xiaobing Qian,1 Susannah Patarroyo-White,1 Amy Parker,1 Tongyao Liu,1 Haifeng Chen,1 Sharon Powell,1 Fraser Wright,1 Shawn Tinlin,2 Sandra Webster,2 David Lillicrap,2 Rita Sarkar,3 Hiag Kazazian,3 Valder Arruda,4 Katherine High,4 Leonard Meuse,5 Kazu Ohashi,5 Mark Kay,5 Alan McClelland.1 Avigen, Inc, Alameda, CA, United States; 2Dept of Pathology, Queen′s University, Kingston, Ontario, Canada; 3Dept of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA, United States; 4Dept of Pediatrics and Pathology, Childrens Hospital of Philadelphia, Philadelphia, PA, United States; 5Dept of Pediatrics and Genetics, Stanford University School of Medicine, Palo Alto, CA, United States C ' -?./ ( ' 8H ?. ' " ?. 8"&H ?. 0 ' ''. ?. 8"& H ''. 2 " ?. -''."?."(S"896/ C ' -C '/ E :: 3898, -/% =3898=% ! ?. >D(' ?. &6H ?. -=:6 4%/ ;;H -&B& 4%/ B ?. :H 8,H ) ' ) E 83898= % 0 E 8&& B -02 M="6 / ?. ! 899",99 4% -8&",& H ?. / 3 -2 / 6 "E " 2 88"8, ="6 -2 M," 6 / ''. ' E 6& ' E ''. 2 " ?. $*' ?. 8H 255 Delivery and Expression of von Willebrand Factor itro cDNAs V ia Hybrid Adenovirus-Retrovirus V ectors In V Vitro Via Vectors and In Vivo Robert G Pergolizzi,1 Neil R Hackett,1 Jennfier S Lee,1 Michael Lam,1 Meelan N Patel,1 Young S Song,1 Changyu Zheng,2 Bruce J Baum,2 Ravi N Singh,1 Ronald G Crystal.1 Weill Medical College of Cornell University, New York, NY, United States; 2National Institutes of Dental and Craniofacial Research, NIH, New York, NY, United States 0 $ -0$/ 8H =H 4( 0$ 3 0 -0?/ 0 0?" 3 0$ Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy =" " 0? G 0?$*'-:B / 1 3 0$ ' % -' D @0?/ -D @ / 0? $*' >8">=">6" ' D @ #. 0?$*' " " >8">=">6" ' D @"0? ,8, - / C , - / '&65 - / C D >3 0? -?'/ 3 " 0? 0 ,6 ?' 0? 3 8 = ' * 0? 0? 1 G 0? $*' 3 8988 ' D @"0? ' * E E 1 &;2%B >D(' 3 0? 0? 6: ' D @"0?"E 0? ' * E - /# 3 0? 0? 3 $ 1 # " -*'($'S 7 *./ ( @ ' ' 8 855: 4