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157 Comparison of the Insulating Properties of Two Genetic Elements in an Adenovirus Molecular Therapy Vol 5, No 5, May 2002, Part 2 of 2 Parts Copyright © The American Society of Gene Therapy S53 ���[.]
" " " " ! D -0/ ! D ' ( ? 8&9 -!2(/ ! -F ,998/ $ G '*).' 3 -'*).' !T98/ ''.%*(>" J ''.%*(>" CJ ":9U = 8 = B E ''. ":9U 1 G ":9U 155 NautCell ™ AA V High Producer Cell Line NautCell™ AAV Nadia Billault,1 Marjorie Flaux,1 Nestor Soria,1 Lila Drittanti.1 NautilusBiotech ' " - ''./ I 3 C ''. 1 " '' ''. '' ,5= C>A # ,999 ,5= C>A 5B ' 8,;9 ''. ) 99, H 8", ''. ''. ,5=C>A 9B"=93896 - / % 9B"=9 389B % -9="=9 3 89B % 89 / 7 8/ - 89 / ,/ ''. - 89 / =/ G -6 / ; ''. 89 6 G ; ,5= ,5= * ™ ''. - / 89 6 G ''. ,5= -O % / * ™ -/ -/ % * ™ =9 " " " " ! 156 The HyV ec System: High-Capacity Adenovirus/ HyVec Lentivirus V ectors Achieve Efficient T wo-Stage Gene Vectors Two-Stage Transfer and Stable Integration of T ransgenes Transgenes Lily J.-L Jih,1 Shuji Kubo,2 Celina Ngiam,1 Maria Barcova,1 Emmanuelle Faure,1 Ji Hee Kim,1 Toshiaki Shichinohe,1,3 Ataru Sazawa,1,3 Ruth Margalit,1 Renata Stripecke,1,3 Paula Cannon,1,4 Noriyuki Kasahara,1,3 Kohnosuke Mitani.2 Vector Development Group, IntraGene Sciences, Inc., Los Angeles, CA, United States; 2Microbiology and Immunology, University of California Los Angeles, Los Angeles, CA, United States; 3Institute for Genetic Medicine, University of Southern California, Los Angeles, CA, United States; 4Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States G " " 1 C." #D." Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy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ovel High-Capacity Adenovirus V ector Vector Expressing Mouse CTLA4Ig and Mouse Application to Treatment of a Mouse Model of Dystrophin Deficiency Zhilong Jiang,1 Xinyan Gu,1 Dan Reay,1 Gudrun Schiedner,4 Stefan Kochanek,4 Paula Clemens.1,2,3 Department of Neurology, University of Pittsburgh, Pittsburgh, PA, United States; 2Department of Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, PA, United States; 3Neurology Service, Department of Veterans Affairs Medical Center, Pittsburgh, PA, United States; 4Center for Molecular Medicine, University of Cologne, Cologne, Germany $ -$#$/ F" ( $#$ -' /" 3 " 3 @ " 3 G " ' -C"' / C"' D'6%$ $*' D'6 ( A" D'6 / / $*' @ D'6 3 C!@ $*'' ( A8,, / / $*' ;8 C!@ 1 B& -#A/ 86 %' 1 @ C B8 C!@ $*' 1 " ,5= 6 ' D: ' S54 2 ( !@ D'6 3 D'6 C D >D(' D'6 89&5±9&% 3 , E ,6 F 895 C"' D'6%$ @ 3 C" ' 1 ) D'6 3 C"' D'6%$ 3 3 159 Adenovirus-Microtubule Organizing Center Interaction and Delayed Kinetics of Adenovirus Association with the Nucleus Following Infection of Endothelial Cells Christopher J Bailey,1 Ronald G Crystal,1 Philip L Leopold.1 Weill Medical College of Cornell University, New York, NY, United States > C G -'@/ " -C#.> / -C4.> / '&65 # 8& " 59 G ' 59 " '&65 C E E 3 ( 1 3 "G G "G G G = " 8& " G G " G " E 0 G % 3 " " G " " 3 '&65 - " / - / ( '@ 3 3 3 3 " G '&65 3 3 1 G G " $ 1 Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy ... ":9U 155 NautCell ™ AA V High Producer Cell Line NautCell™ AAV Nadia Billault,1 Marjorie Flaux,1 Nestor Soria,1 Lila Drittanti.1 NautilusBiotech '' " - ''''./