502107 2013 JRA15410.1177/1470320313502107Journal of the Renin-Angiotensin-Aldosterone SystemLin et al Original Article Angiotensin-converting enzyme insertion/ deletion polymorphism associated with allergic rhinitis susceptibility: Evidence from 1410 subjects Journal of the Renin-AngiotensinAldosterone System 2014, Vol 15(4) 593–600 © The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav DOI: 10.1177/1470320313502107 jra.sagepub.com Hai Lin1,*, Dong Lin2,* and Chun-Quan Zheng1 Abstract Background and objective: Whether the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene increases susceptibility to allergic rhinitis (AR) is still undetermined Therefore, this meta-analysis was performed to systematically assess the possible association between them Methods: The OVID, Medline, Embase, Web of Science, CNKI and Wangfang databases were searched to identify the eligible studies focusing on the association between ACE I/D polymorphism and susceptibility to AR Results: A total of 1410 subjects from six studies were subjected to meta-analysis In the overall analysis, ACE I/D polymorphism had a statistically significant association with increased AR risk under all genetic models (p