CytoJournal Executive editor: Vinod B Shidham, MD, FIAC, FRCPath Wayne State University School of Medicine, Detroit, MI, USA Co-editors-in-chief: Richard DeMay, MD (University of Chicago, Chicago, USA) Vinod B Shidham, MD, FIAC, FRCPath (WSU School of Medicine, Detroit, USA) For entire Editorial Board visit : http://www.cytojournal.com/eb.pdf PDFs FREE for Members (visit http://www.cytojournal.com/CFMember.asp) OPEN ACCESS HTML format Research Article Constructing a modern cytology laboratory: A toolkit for planning and design Janie Roberson, SCT (ASCP), Allison Wrenn, CT (ASCP), John Poole, AIA, Andrew Jaeger, Isam A Eltoum, MD, MBA* Address: Department of Pathology, Division of Anatomic Pathology, University of Alabama at Birmingham, USA E‑mail: Janie Roberson - jroberson@uabmc.edu; Allison Wrenn ‑ awrenn@uabmc.edu; John Poole - jpoole@pooleandcompany.com; Andrew Jaeger - ajaeger@hksinc.com; Isam A Eltoum* ‑ ieltoum@uab.edu *Corresponding author Published: 28 February 2013 CytoJournal 2013, 10:3 This article is available from: http://www.cytojournal.com/content/10/1/3 © 2013 Roberson, et al.; licensee Cytopathology Foundation Inc Received: 18 June 2012 Accepted: 24 January 2013 This article may be cited as: Roberson J, Wrenn A, Poole J, Jaeger A, Eltoum IA Constructing a modern cytology laboratory: A toolkit for planning and design CytoJournal 2013;10:3 Available FREE in open access from: http://www.cytojournal.com/text.asp?2013/10/1/3/107983 Abstract Introduction: Constructing or renovating a laboratory can be both challenging and rewarding UAB Cytology (UAB CY) recently undertook a project to relocate from a building constructed in 1928 to new space UAB CY is part of an academic center that provides service to a large set of patients, support training of one cytotechnology program and one cytopathology fellowship training program and involve actively in research and scholarly activity Our objectives were to provide a safe, aesthetically pleasing space and gain efficiencies through lean processes Methods: The phases of any laboratory design project are Planning, Schematic Design (SD), Design Development (DD), Construction Documents (CD) and Construction Lab personnel are most critical in the Planning phase During this time stakeholders, relationships, budget, square footage and equipment were identified Equipment lists, including what would be relocated, purchased new and projected for future growth ensure that utilities were matched to expected need A chemical inventory was prepared and adequate storage space was planned Regulatory and safety requirements were discussed.Tours and high level process flow diagrams helped architects and engineers understand the laboratory daily work Future needs were addressed through a questionnaire which identified potential areas of growth and technological change Throughout the project, decisions were driven by data from the planning phase During the SD phase, objective information from the first phase was used by architects and planners to create a general floor plan This was the basis of a series of meetings to brainstorm and suggest modifications DD brings more detail to the plans with engineering, casework, equipment specifics, finishes Design changes should be completed at this phase The next phase, CD took the project from the lab purview into purely technical mode Construction documents were used by the contractor for the bidding process and ultimately the Construction phase Access this article online Results: The project fitted out a total of 9,000 Quick Response Code: Website: square feet; 4,000 laboratory and 5,000 office/ www.cytojournal.com support Lab space includes areas for Prep, CT screening, sign out and Imaging Adjacent DOI: space houses faculty offices and conferencing 10.4103/1742-6413.107983 facilities Transportation time was reduced (waste removal) by a Pneumatic Tube System, CytoJournal 2013, 10:3 http://www.cytojournal.com/content/10/1/3 specimen drop window to Prep Lab and a pass thru window to the screening area Open screening and prep areas allow visual management control Efficiencies were gained by ergonomically placing CT Manual and Imaging microscopes and computers in close proximity, also facilitating a paperless workflow for additional savings Logistically, closer proximity to Surgical Pathology maximized the natural synergies between the areas Conclusions: Lab construction should be a systematic process based on sound principles for safety, high quality testing, and finance Our detailed planning and design process can be a model for others undertaking similar projects Key words: Cytolaboratory design, laboratory design, lean methods, quality control, laboratory construction, cytopathology equipments, cytopathology procedures INTRODUCTION METHODOLOGY Constructing or renovating a laboratory can be both challenging and rewarding The UAB Cytology Section recently had the opportunity to relocate services from a building constructed in 1928 to a new space The laboratory provides diagnostic and screening services for UAB Medicine patients, which include a 1000‑bed hospital and a large Outpatient Clinic Over 20,000 tests, including both conventional and liquid‑based gynecological cases, 1000 fluid specimens, 2000 Fine Needle Aspirations (FNA), and 1000 pulmonary cases are processed annually Internally, the section supports an onsite rapid FNA service for Endoscopic Procedures (EUS) as well as for Mammography and Bronchoscopy (EBUS) The technical and professional staff attend and perform FNAs throughout the inpatient and outpatient areas The laboratory serves as a clinical affiliate site for Cytotechnology Programs, supports two Cytopathology Fellowships, Residents, and a Professional staff, active in research and publication As an academic institution, our mission includes patient care, research, and education; and our facilities must be able to accommodate these functions seamlessly Once a project has been approved in concept, the core stakeholders must be identified and assembled as a project team The composition of this group will vary depending on the facility type Even as academic institutions, corporate laboratories, and hospitals have variable business models, there are common roles and areas of expertise that must be represented in the composition of the project team Each member will have expectations to be met during specific phases of the project[2] [Figure 1] Our challenge in the laboratory design and building project has been to develop a plan that demonstrated flexibility, safety, quality of environment, and cost efficiency Flexibility is important, as laboratory testing is constantly changing and to remain competitive, we must be able to accommodate future growth in both test volume and diversity Safety of the employees is a major concern in areas with potential chemical exposure and biohazards Additionally, there are numerous agencies, with applicable safety mandates, which require compliance A well‑designed, high‑quality work environment is evidence of our commitment to patients and employees and fosters satisfaction and high performance among the staff As a teaching facility, recruiting the best staff available is a priority and top‑level facilities attract top‑level staff Cost efficiency is always a concern and can be a limiting factor, if not carefully monitored throughout the planning and design.[1] The phases of project design are Planning, Schematic Design (SD), Design Development (DD), Construction Documents (CD), and Construction.[3] PLANNING Laboratory participation (User Group) is the most critical in the planning phase Detailed information regarding the methodologies and scope of testing performed by the laboratory must be compiled and conveyed to the others on the project team Administrative and facility members also participate, to ensure that the plans remain within the financial and physical constraints and are aligned with long‑term institutional strategies Tours and high‑level process flow diagrams can bring Figure 1: Project team composition CytoJournal 2013, 10:3 an understanding of the daily work in the laboratory to architects and engineers Awareness of the appropriate relationships and adjacencies are essential to the design for a smooth flow of personnel, supplies, and equipment The strength and complexity of these relationships can be illustrated through a bubble diagram [Figure 2] Any discussion of an efficient facility design must include planning for sustainable design and Lean operations For example, materials handling is estimated to consume 20-50% of the operating expense in a variety of production and manufacturing settings, not atypical of laboratories Efficient facility design can reduce these costs by 10-30%; an excellent return on investment over the life of the facility.[4] Objectives of Lean facility planning are, obtaining a smooth work flow, reducing the walking distances and work in progress, improving visibility for effective management of operations, and improving the work environment and inventory management.[5] Along with Lean design concepts, this detailed planning information covers personnel, equipment, and future growth The more information compiled at this stage, the more completely the outcome will meet the user group needs An equipment list with specifications, including what will be relocated, newly purchased, and projected for future growth, ensures that utilities are matched to need The list must include: Footprint (dimensions and weight), electrical requirements, computer or interface requirements, uninterruptible power supply (UPS), alarm, dedicated circuit, emergency power, ventilation or exhaust, and a plumbing drain or deionized (DI) water [Table 1] Cut sheets must also be available for each piece of equipment, conveying any information needed to install or use the product A quantitative chemical inventory is essential to provide the appropriate storage space This inventory must include the chemical name, storage requirements, http://www.cytojournal.com/content/10/1/3 and volume stored [Table 2] Storage of used reagents and residual specimen containers/fixatives must also be included in this volume The National Fire Protection Association (NFPA) provides ratings for areas based on volume and potential hazards Anatomic pathology laboratories, because of the high volumes of xylene and formalin, are typically rated as Class A Regulatory and safety requirements must be discussed as they relate to the specimen sources and testing to be performed A BioSafety level is the level of bio‑containment precautions required to isolate dangerous biological agents in an enclosed facility The levels of containment range from the lowest, BioSafety level 1, to the highest, level In the United States, the Centers for Disease Control and Prevention (CDC) have specified these levels.[6] Once determined, this level will dictate many of the safety requirements for the laboratory Our project and the typical cytology wet laboratory space is designated as BioSafety Level (BSL2) Future utilization must be addressed through a questionnaire and/or discussions among stakeholders Even as future needs are difficult to predict, this exercise can identify the potential areas of growth and direction of technological change A universally accepted growth area in laboratories is automation in processing and specimen tracking, which will necessitate more electrical and data capacity than in the previous workplace DESIGN Throughout the Schematic Design, data and information from the planning phase is used by architects and planners to create a general floor plan This design provides the groundwork for a series of meetings, to brainstorm and modify the plan To ensure maximum efficiency, the workflow (movement of specimens) and traffic flow (movement of personnel) must be carefully evaluated during this phase [Figure 3] Specimen preparation and result reporting are bookends to the cytological testing process, providing both pre‑analytic and post‑analytic support One of the objectives in the design of the preparation area is to allow two to three operators to effectively and simultaneously cover several instruments and functions To achieve this, handling and walking distances are minimized and open areas are provided to facilitate visual management Open work areas also allow managers to quickly assess the state of operations, inventory levels, and communication among workers, a key feature of Lean design Another key requirement of this area is broad accessibility to other functional areas, specimen couriers at all hours, pathology sign out area, cytotechnologist screening, and imaging and archive Figure 2: Bubble diagram illustrating strength and complexity of relationships, both internal and external, to the laboratory Many of the laboratory safety mandates directly impact Centrifuge, Cytological, Model Cytospin 4, Thermo Centrifuge, accuSpin ™ Fisher Scientific Centrifuge CL2, IEC Oven (drying) Model 299-7405, Equatherm Oven (drying) L-C Labline Microscope, Model DMLS, Leica Vortex Model g-560, Genie Slide Stainer, Gemini Thermo Electron Slide Stainer, Gemini Thermo ElectronPower Supply Unit and Monitor Slide Stainer, Leica Autostainer, XL Refrigerator, Specimen, Sci Cool (accessible after hours) Refrigerator,VWR Specimen and reagents Thinprep Processor 2000, Cytyc Corp Thinprep Imaging Station, Image Processor Controller IPC, Server, User Interface Monitor, Keyboard, Mouse, Printer Cellient Automated Cell Block Processor Cellient Automated Cell Block Finishing Station Dishwasher (proposed) Screening/Sign out/Conference Imaging Microscopes Microscope BX40CY Olympus Microscope, Model DMLS, Leica Microscope – head, Olympus B-max 50 with Digital Camera-DP12, Monitor Microscope- head, Olympus BH2 with camera Microscope –6 head, Olympus, BX40 Microscope 15 Head Olympus KB505 Processing Biohazard Cabinet, Baker 10 3/4x13 1/4x 15 3/4 29 lbs 21W17D29H 21W16D30H Approx 17W 12D 24H 6.5x4.8x6.5 8.8 lbs 28.5x28x34.5 176lbs 14x18.25x6.5 24 lbs 42.9x26.4x20.1 143.3 lbs 36W 30D 67H 32W 29D 71H 17x18x19.5 41 lbs Requires 72x30" bench 300 lbs 30x23.5x23.5 140 lbs 6.5x14.5x6.8 14 lbs 1 1 1 1 1 1 Equipment specifications N N Y 1 60X20 Table Y N N Y N N 200 N Y 4 6.3 6.3 N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N Y N N N N N N N Y N N N N N N N N N N N N N N N N N N N N N N N N Y N N N N N N N N N N N N N Amps Watts Network Alarm Dedicated UPS connection Circuit N 100-241 100-240 100 110-240 110-120 120 100-240 120 120 120 120 120 Volts Approx 17W 12D 24H 18.1x21.3x16.1 114.6 lbs 1 62W x32D vented into ceiling 600-800 lbs 15W22D10H Size WxDxH/ Lbs # Table 1: Equipment specifications (CLSI format) Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y N N N N N N N N N N N N N N N N N N N N N N N N Y Emergency Vent Power out N N N N N N N Y N N N N N Y N N N N Y N N N N N N Drain N N N N N N N Y N N N N N Y/DI N N N N Y N N N N N N Water CytoJournal 2013, 10:3 http://www.cytojournal.com/content/10/1/3 CytoJournal 2013, 10:3 http://www.cytojournal.com/content/10/1/3 Table 2: Chemical inventory with quantification and hazard classification Chemical Inventory Room # Section Chemical Name Quantity Max In Physical Inventory State Hazard Class Health Flammability Reactivity Cytology Manufacturer Corrosive Bluing Reagent 4g Liquid 0 Clarifier 4g Liquid ACID Richard-Allan Scientific Richard-Allan Scientific Clorox 8g Liquid COR THE CLOROX CO Cytostain (Richard-Allan) 2g Liquid Richard-Allan Scientific ThinPrep® CytoLyt® Solution 1g Liquid Hologic Diff Quick Fixative 3g Liquid Richard-Allan Scientific Diff Quick Solutions I and II 4g Liquid Richard-Allan Scientific Ethanol 100% and 95% 40 g Liquid Formalin 3g Liquid COR Hanks Balanced Salt Solution 2g Liquid 0 Hematoxylin 2g Liquid 1 Mounting Media 1g Liquid Spray Disinfectant CANS Aerosol Thinprep® Bluing solution 2g Liquid Richard-Allan Scientific Cardinal Health GIBCO Richard-Allan Scientific Richard-Allan Scientific Cavicide 0 Hologic Thinprep® EA Solution 2g Liquid Hologic Thinprep® Nuclear Stain Solution 2g Liquid 0 Hologic Thinprep® Orange G solution 2g Liquid Hologic Thinprep® Rinse Solution 2g Liquid Hologic Thinprep® Preservcyt Supplies 5g Liquid Hologic Thinprep® Preservcyt Residual 5g Liquid Hologic Xylene Liquid Richard-Allan Scientific 10 g the preparation area and must be built into the design for appropriate plumbing and electrical support and ease of access for staff.[7,8] A safety checklist is provided in Table The Occupational Safety and Health Administration (OSHA) regulates and the American National Standards Institute (ANSI) provides standards (ANSI/ISEA Z358.1‑2009) for emergency shower and eye wash station equipment OSHA’s general regulation ([29 CFR 1910.151 (c)]) states that: “Where the eyes or body of any person may be exposed to injurious corrosive materials, suitable facilities for quick drenching or flushing of the eyes and body shall be provided within the work area for immediate emergency use.”[9] Table lists these standards In contrast to the preparation area, cytotechnologists performing the analytic phase of testing, screening, and diagnostics, require a workspace with more restricted access, to minimize interruptions Multifunction workstations, with carefully considered ergonomics, must be designed, due to the repetitive nature of screening.[10] To reduce the movement of personnel and specimens; the workspace is designed to accommodate both manual and automated microscopes as well as computers An open area, with individual work cubicles and a common resource area for educational materials, meets the needs of rotating trainees Slides ready to be screened are transferred from the preparation to the screening area using a ‘pass thru’ cabinet This minimizes interruptions and also helps to maintain the positive/negative airflow between the two areas Conferencing facilities are a high priority for academic institutions A multipurpose space is designed, allowing a multihead microscope review as well as overhead projection and presentation resources A moveable wall provides the capability of separating the two functions as needed Locating this adjacent to the lounge facilitates food service, often a component of functions and conferences The Americans with Disabilities Act (July 26 1990) requires that public entities ensure that newly constructed buildings CytoJournal 2013, 10:3 http://www.cytojournal.com/content/10/1/3 Figure 3: Schematic design illustrating movement of people and materials and facilities are free of architectural and communication barriers that restrict access or use by individuals with disabilities The accessibility guidelines (ADAAG) are numerous and detailed, however, compliance is relatively simple if addressed early in the project [Table 5].[11] Design development, the third phase, brings more detail to the schematic design, with addition of engineering, casework, equipment specifics, and finishes For long‑term savings, requirements for sustainable design and energy efficiency must be specified.[12] Examples of this are motion sensor, timed lighting, and planned air conditioner zones, to accommodate the heat generating equipment Moveable casework will allow for adaptation to changing instrumentation Use of open casework promotes the Lean concept of visual assessment [Figures 4‑7] As the project moves to Construction Documents, the work transfers from the laboratory purview to a purely technical mode At this point, due to costs, design changes must not be made Architects and engineers provide more detail and specifications to allow qualified contractors to participate in the bid process During the construction phase, architects and engineers serve as liaisons between the construction team and owners, to ensure compliance with the construction documents The user group tours the space periodically to verify that the construction meets the expectations of the planning and design phases Change orders may be generated during this phase, however, they add to the project cost and must be minimized Although not a phase of construction and beyond the scope of this article, it must be noted that detailed plans for the actual move‑in must begin early, as they can significantly impact the workflow and the project budget Vendors must be notified well in advance for quotes and schedules for equipment transport and set up Carefully developed detailed crosswalks from the old to the new CytoJournal 2013, 10:3 http://www.cytojournal.com/content/10/1/3 Table 3: Safety checklist and BLSI requirements Safety Checklist BioSafety Level Requirements Automatic fire extinguishing system All BSL1 Requirements Two exit access doors, if required Facial protection Audible automatic fire detection and alarm system Hand washing with antibacterial soap Fire alarm station Disinfect all exposed surfaces of the lab Portable fire extinguishers Emergency lighting Flammable and combustible liquid storage Acid and base storage Emergency eye wash Hand washing sink Emergency Shower PPE Storage BioSafety Cabinet Requirements Negative and Positive Pressurization areas Chemical ventilation Gloves Table 4: Eyewash and emergency shower specifications Eyewash and Emergency Shower Specifications Heads Plumbed Eyewash Station Plumbed Emergency Shower - Positioned 33"—45" from floor - Positioned 82"—96" from floor - Positioned 6" from wall - Spray pattern will have or nearest obstruction a minimum diameter of 20" at 60" above the - 0.4 gallons per minute floor (GPM) for 15 minutes (provides flushing fluid - Flow Rate=20 gallons at 30 PSI) per minute (GPM) at 30 pounds per square inch (PSI) Specific training in handling pathogenic agents directed by scientists with advanced training - Center of the spray pattern at least 16 inches from any obstruction Limited access to the laboratory Extreme precautions are taken with contaminated sharp items Use of biological safety cabinets or other physical containment equipment when infectious aerosols or splashes may be created BSL Requirements Table 5: Americans with disabilities act requirements Doorways 32” with the door open 90º degrees Wheelchairs Single wheelchair passage 32”at a point and 36”continuously Turning space-60” clear space for 180º turn Reach Forward 15”-48” Side (parallel approach) 9”-54” Sinks and fountains Spouts 36” maximum Valves - Activate in second or - Activate in second or less less - Stay-open valve (leaving - Stay-open valve (no use hands free) of hands) Valve remains on until the user shuts off Installation - Requires no more than - Requires no more than 10 seconds to reach 10 seconds to reach - Located in a well-lit - Located in a well-lit area area and identified with and identified with a a sign sign - Located on the same level as the hazard - Located on the same level as the hazard - Activated weekly to - Activated weekly to Mainteverify correct operation verify correct operation nance and Training - Training for all - Training for all employees who might employees who might be exposed to a be exposed to a chemical splash chemical splash - Inspected annually to ensure ANSI Z358.1 compliance - Inspected annually to ensure ANSI Z358.1 compliance Lavatories 34” maximum, at least 29” to the bottom of the apron Knee clearance 27” high, 30”wide, and 19” deep underneath sinks space for phones and computers, ensure a seamless transfer of this equipment Customers and supply chains must be informed of the potential interruption of service The vacated space must be cleared of all chemical and biological hazards as well as any Protected Health Information (PHI) RESULTS At completion, the project fitted out a total of 9000 square feet; 4000 square feet of laboratory space and 5000 square feet of office/support space The laboratory space included areas for preparation, CT screening, sign out, and imaging The adjacent space housed faculty offices, support staff, and conferencing facilities Our objectives for building a Lean facility were essentially met The workflow was improved by moving specimens and their derivatives in a linear motion, from receipt to final verification Walking distances (transportation) were greatly reduced by the installation of a Pneumatic Tube System (PTS), specimen drop window directly into the Prep area, and a pass thru cabinet to the screening area Logistically, CytoJournal 2013, 10:3 Figure 4: Gyn-cytology processing elevation Figure 5: Accessioning and staining coverslipping in an open work area http://www.cytojournal.com/content/10/1/3 CytoJournal 2013, 10:3 http://www.cytojournal.com/content/10/1/3 Figure 6: Accessioning, staining, flammable cabinet, and refrigerated storage Figure 7: Elevation 07: Non-Gyn processing CytoJournal 2013, 10:3 closer proximity to Surgical Pathology maximized the natural synergies between these areas Open floor plans for the main functional areas and screening and preparation, improved visibility for a more effective management of operations The overall work environment was improved with better lighting, aesthetics, conferencing facilities, information technology, and employee comforts Inventory management was more efficient, with accessible areas appropriate for short‑term and long‑term storage Security was managed by key‑code and card access entry and the slide archive area could only be accessed by authorized individuals Surveillance cameras were also strategically located for added security Efficiencies were gained by ergonomically placing manual and imaging microscopes in customized work cells for cytotechnologists Location of computers in close proximity and the addition of bar code scanners facilitated a new paperless workflow for additional savings SUMMARY For Cytology, the past decade has brought tremendous technological change to what for half a century, has largely experienced predictable and constant practice Automated stainers and cover slippers, liquid‑based processors, and imaging systems are now a standard of practice in most laboratories These advances in instrumentation require bench space and facility modifications not seen in traditional cytology laboratories With the expected decrease in volume of routine Pap tests and growth and integration of molecular testing, future cytology laboratories will demand an increasingly more technologically sophisticated workplace Planning, design, and construction must incorporate the flexibility to allow this change at a minimal time and cost Infrastructure and information technology must be able to support networked instruments, mobile devices, wireless connectivity, digital projection, and high quality audio‑visual technology Successful laboratory construction must be a systematic process, based on sound principles, to provide flexibility, safety, quality of environment, and cost efficiency Throughout the project, decisions must be driven by data gathered in the planning phase This careful planning and design can ensure that the laboratory we build today will adapt to the laboratory we need tomorrow COMPETING INTEREST STATEMENT BY ALL AUTHORS The author(s) declare that they have no competing interest AUTHORSHIP STATEMENT BY ALL AUTHORS All authors declare that we qualify for authorship as defined by ICMJE http://www.icmje.org/#author Each author aknowledges that this final version was read and approval 10 http://www.cytojournal.com/content/10/1/3 ETHICS STATEMENT BY ALL AUTHORS This article content does not require approval from Institutional Review Board (IRB) at out institution Authors take responsibility to maintain relevant documentation in this respect REFERENCES Research Laboratory Design Guide, Department of Veterans Affairs Office of Research and Development, Office of Facilities Management September 30, 1995 Available from: http://www.wbdg.org/ccb/VA/VADEGUID/lab.pdf [Last accessed on 2012 Jan 18] Mortland K Laboratory Design for Today’s Technologies, MedTechNet East Amherst, NY; May 1997 p 1‑14 Clinical and Laboratory Standards Institute Laboratory Design; Approved Guideline ‑Second Edition CLSI document GP18‑A2 [ISBN 1‑56238‑631‑X] Clinical and Laboratory Standards Institute 940 West Valley Road, Suite 1400 Wayne, Pennsylvania 19087‑1898 USA, 2007 Joseph T Design Your Laboratory of the Future Available from: http://www sprickstegall.com [Last accessed on 2011 Sept] Lean Boot Camp: CLMA Immersion Day, presented by Susan Stegal www sprickstegall.com Centers for Disease Control and Prevention, Summary of BioSafety Levels‑1 and http://emergency.cdc.gov/documents/PPTResponse/table3abiosafety pdf [Last accessed on 2012 Jan 18] College of American Pathologist http://www.cap.org Lab General Checklist 7/11/2011 NCCLS Clinical Laboratory Safety: Approved Guideline‑Second Edition NCCLS document GP17‑A2 [ISBN 1‑56238‑530‑5] NCCLS 940 West Valley Road, Suite 1400 Wayne, Pennsylvania 19087‑1898 USA; 2004 Eyewash and Safety Shower Requirements Available from: http://gesafety com/ansi/index.shtml Last accessed 02/2013 10 Ergonomics Checklist Available from: http://www.ehs.ucr.edu/ehsacademy/ presentations/ergonomicslaboratorychecklist.pdf [Last accessed on 02/2013] 11 Available from: http://www.ada.gov/2010ADAstandards [Last accessed on 2011 Aug] 12 Supporting Integrated Design through Interlinked Tools: The Labs21 Toolkit Available from: http://www.labs21century.gov/ [ Last accessed on 2012 Jan 18] EDITORIAL / PEER‑REVIEW STATEMENT To ensure the integrity and highest quality of CytoJournal publications, the review process of this manuscript was conducted under a double blind model (authors are blinded for reviewers and vice versa) through automatic online system The FIRST Open Access cytopathology journal Publish in CytoJournal and RETAIN your copyright for your intellectual property Become Cytopathology Foundation Member to get all the benefits Annual membership fee is nominal US $ 50 (US $ 1000 for life) In case of economic hardship it is free For details visit http://www.cytojournal.com/CFMember.asp PubMed indexed FREE world wide open access Online processing with rapid turnaround time Real time dissemination of time-sensitive technology Publishes as many colored high-resolution images Read it, cite it, bookmark it, use RSS feed, & many www.cytojournal.com Peer-reviewed academic cytopathologyjournal Copyright of CytoJournal is the property of Medknow Publications & Media Pvt Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission However, users may print, download, or email articles for individual use ... staff.[7,8] A safety checklist is provided in Table The Occupational Safety and Health Administration (OSHA) regulates and the American National Standards Institute (ANSI) provides standards (ANSI/ISEA... Residents, and a Professional staff, active in research and publication As an academic institution, our mission includes patient care, research, and education; and our facilities must be able to accommodate... performance among the staff As a teaching facility, recruiting the best staff available is a priority and top‑level facilities attract top‑level staff Cost efficiency is always a concern and can