Dental Science - Original Article Administration of bisphosphonate (ibandronate) impedes molar tooth movement in rabbits: A radiographic assessment V Venkataramana, S Sathesh Kumar1, B Vishnuvardhan Reddy2, A Sreekanth Cherukuri2, K Raja Sigamani3, G Chandrasekhar Department of Orthodontics, Panineeya Mahavidhyalaya Institute of Dental Sciences, Dilshuknagar, Hyderabad, Andhra Pradesh, 1Department of Orthodontics, JKKN Dental College, Komarapalyam, Namakkal, 2Department of Orthodontics, G Pulla Reddy Dental College and Hospital, Kurnool, Andhra Pradesh, 3Department of Orthodontics Rajah Muthiah Dental College, Annamalai University, Chidambaram, Tamilnadu, India ABSTRACT Introduction: Bisphosphonate (Bp)‑ibandronate is a pharmacological agent, exhibits antiosteoclastic or antiresorptive activity and used to treat osteolytic or osteopenic disorders BP‑ibandronate may also interfere during orthodontic tooth movement The aim of this study was to examine the influence of locally administered Bp‑ibandronate on experimental tooth movement in rabbits Materials and Methods: Twenty rabbits were divided into two groups‑ “10” served as Group‑1 (control) and other “10” as Group‑2 (experimental) Both groups received nickel‑titanium closed coil springs with 100 g force between mandibular molar and incisors Group‑1 animals received 1 ml normal saline and Group‑2 animals received ibandronate solution (0.3 mg/kg body weight) locally, mesial to the mandibular molar on the 1st, 7th, and 14th day of the experiment A total of “40” lateral cephalograms were taken from both groups on the 1st and 21st day using a digital X‑ray unit (Siemens X‑ray systems, 300 mA Pleomophos analog, 2008, Germany) Individually, each animal’s radiograph was traced manually and superimposed The molar tooth movement was measured with the help of a standard metric scale Results: The Student’s t‑test has been done to compare the mean values of Group‑1 (4.650 ± 0.363) and Group‑2 (2.030 ± 0.291) and the difference was statistically significant (P