Index 450 Hypersplenism 130, 148, 151, 153, 278, 415, 420 Hypertension aortic dissection .25, 28, 30, 49, 57, 60 Conn’s 348 cushing’s syndrome 57 hyperaldosteronism 348–349 pheochromocytoma .34, 57, 143, 281, 348–349 post-operative 392, 425–426 in pregnancy 409 Hypertensive cardiomyopathy 34 Hypertensive emergency 57–58 Hypertensive retinopathy 57, 338, 348 Hypertensive urgency 57–58 Hyperthyroidism 15, 19, 39, 42, 44–45, 57, 65, 90, 111, 124, 233, 309, 318, 332, 337, 344–346, 353–355, 361, 374, 412, 414, 420 in pregnancy 414 Hypertrichosis 180, 357, 421 Hypertriglyceridemia 61–62, 80, 227 Hypertrophic cardiomyopathy 40, 43, 45–48, 53, 64, 312 Hypertrophic obstructive cardiomyopathy (HOCM) 38, 42, 45, 48 Hypertrophic osteoarthropathy .185, 374–375 Hypertrophy criteria 63–64 Hyperventilation 19, 78, 83, 94, 315 Hyperviscosity syndrome 178, 180 Hypnic headaches .314 Hypocalcemia 63, 65, 89, 101, 139, 229, 309, 332, 352–353, 414 Hypogammaglobulinemia 5, 8, 170, 189 Hypoglycemia 39, 59, 83, 100, 103, 105, 107–108, 128–129, 203, 206, 226, 240, 299, 309–310, 337, 340–342, 385, 412, 414, 425, 427 Hypokalemia 18, 38–39, 63, 65, 78–79, 81–82, 86, 89, 104–105, 108, 126, 135, 332, 347–348, 396, 406 Hypokinetic movement disorders .320 Hypomagnesemia 38–39, 63, 78–79, 81, 83, 89, 105, 126, 135, 227, 276, 381, 396 Hyponatremia acute 80 chronic 80 hyperosmolar 80 hypoosmolar 79–80 isoosmolar 80 pseudo 80 Hypophosphatemia 18, 83–84, 89, 103, 105, 227, 332, 352–353 Hypotension 8, 25, 27, 29–30, 32–33, 48, 52, 59, 89–90, 97, 100, 103–105, 107–109, 118–120, 122–123, 129, 135, 137, 140, 146, 149, 168, 201–202, 227, 233, 235, 237–239, 248, 257, 312–313, 315, 328, 337, 344, 348–349, 352, 365, 373, 382–383, 385 Hypothermia 64, 81, 91, 103, 107–108, 343, 381 Hypothyroidism 10, 17, 32, 34, 39, 42, 57, 61, 79–80, 98, 107–108, 126, 135–137, 145–147, 173, 180–181, 202, 220, 227, 276, 281, 287, 328, 332, 343, 345–347, 356–357, 361, 378, 381, 390, 394, 396, 414, 420–421 in pregnancy 414 Hypoventilation 15, 18, 78, 92–93, 146, 403 Hypovolemia 71, 80–81, 118–119, 229 Hypoxemia 4, 8, 15–18, 35, 38, 92–94, 96–97, 101, 104, 108–109, 134–135, 147, 233, 235, 237, 239 Hypoxemic respiratory failure 93 I Idiopathic hirsutism 357–358 Idiopathic/immune thrombocytopenic purpura (ITP) 132, 151–153, 170, 415 Idiopathic pulmonary fibrosis 16, 20–21, 374 IgA nephropathy 70–73, 75, 76, 288, 361 Imaging abdominal X-rays (AXR) 396 chest radiography CT chest neurology 297, 302 Imatinib 149, 166, 169, 203, 227, 231 Immune reconstitution syndrome (IRIS) .262 Immunization 147–148, 163, 233–234, 237, 239, 261, 269–271, 365 Immunocompromised patients 266–267 Impetigo 247, 365–366 Incidentaloma 348 adrenal 348–349 Incontinence 12, 68, 103, 210, 212, 228, 231, 244, 298, 310, 312, 323, 377–380, 383–385, 403 Incoordination 135, 308, 319–320, 382 Indirect factor Xa inhibitors .160–161 Indolent lymphomas 175 Infection control 269–270 Inferior vena cava obstruction 207 Inflammatory arthritis 278, 283, 286 Inflammatory back pain .284 Inflammatory bowel disease (IBD) 5, 8, 118, 120–123, 120–122, 125, 127, 129, 155, 156, 174, 212, 220, 223, 234, 239, 273, 276–277, 282–283, 367, 374, 405, 420 extra-intestinal manifestations 121, 283 Inflammatory cardiomyopathy 34 Inflammatory myopathies 279, 281, 292–293, 332 Influenza vaccination 2, 4, 7, 148, 239, 261, 264 Infusion reactions 194, 228, 269 Inhaled medications Inotropes 28–30, 98–100, 399 Insomnia 12, 17, 42, 106, 350, 390, 418–419, 421 Insulin 59, 62, 82–83, 100, 104, 201, 261, 337–342, 347, 350, 357–358, 397, 403, 407, 414, 423, 425, 427 principles of use 341–342 Insulin resistance syndrome 62 Intensive care admission criteria 89 general issues 89–92 mechanical ventilation 89 preventative strategies 89 procedures 89–90 prognosis 90 sedation 89 weakness 89 International prognostic index follicular lymphoma 175 Hodgkin’s lymphoma 173 non-Hodgkin’s lymphoma 175 Internuclear ophthalmoplegia (INO) .306–308 Interstitial lung disease 3, 5, 8, 12, 15–17, 20–21, 23, 33, 92, 148, 281 Intoxication 38–39, 68, 91, 103, 105, 107, 135, 299, 380 Intracerebral hemorrhage 93, 106, 147, 243 Intrahepatic cholestasis of pregnancy 411–412 Intubation 1–2, 4–5, 13, 18, 78, 89–91, 94–95, 97, 99–100, 103–104, 108–109, 243, 269, 311, 338, 373, 399 impending Iodine uptake study 345 Irinotecan 187, 196, 198–200, 226, 230–231 Iron deficiency anemia 144, 163, 199 Iron index 420 Irritable bowel syndrome (IBS) 124, 126–127, 239, 287, 396 Ischemia criteria 28 Ischemic cardiomyopathy 34, 93 Ischemic colitis 115, 118, 120, 122, 125 Ischemic stroke 9, 30, 147, 299, 302–303, 313 Isolations 36, 148, 235, 251, 265, 267, 269 Isometric exercises 45 Itraconazole 3, 237, 261, 266–268, 363, 386 J Janeway lesions 53 Jaundice 46, 52, 121, 128–131, 133, 138–140, 145–146, 163, 181, 185, 190, 201, 203–207, 209, 218, 240, 283, 344, 405, 411–412 Index Joint aspirations 274 Joint pain crystal arthropathy 286 osteoarthritis 273, 275–276, 285–287, 347, 353, 403 rheumatoid arthritis 5, 11, 13, 15–16, 18, 25, 32, 47, 71, 78, 164, 233, 273, 276–280, 282, 286, 288, 292, 318, 323, 328, 332, 355, 368, 420 septic arthritis 53, 258, 273–274 systemic lupus erythematosus 279–281 Jones criteria 51 Jugular venous pressure (JVP) 15, 30, 32–36, 43–44, 46, 50, 52, 64, 68, 71, 98, 412 K Karnofsky performance status 186, 208, 298, 400 Keratoconjunctivitis sicca 273, 278–279 Keratoderma blennorrhagica .283 Kernig sign 242 Kidney mass 57, 116 Killip class classification 27 King’s College criteria 103, 129 acetaminophen overdose 103 Knee examination 295 Korsakoff’s amnesia .107 Krukenberg tumor .197 Kussmaul breathing 107, 395 Kwashiorkor syndrome 126 L Labral tear 295 b-lactamase resistance 253 Lactoacidosis .340 Lacunar stroke .299 Lambert–Eaton syndrome (LES) 318–319, 328 Latent tuberculosis 251 Lee criteria 423 Leg pain 56 Leg swelling 8, 10, 13, 158, 207 unilateral 8, 158 Leptomeningeal meningitis 176 Leptospirosis 34, 173, 233, 238, 240 Leser-Trelat sign 197, 370 Lesions acneiform 363 exanthematous 364–365 nodules 371 papulosquamous 362 pigmented 368 pruritic 361, 363 ulcers 368 vesicular/bullous 365, 371 Letrozole 192–193, 227 451 Leukemia acute lymphoblastic leukemia 167, 169–170, 177 acute myelogenous leukemia 166–168, 181 chronic lymphocytic leukemia 167, 170–171, 173, 179, 181 chronic myelogenous leukemia 100, 150, 165–166, 227 definition 166 Leukemic cutis 167 Leukocyte alkaline phosphatase 165 Leukocytoclastic vasculitis 289 Lewy body dementia 321, 328 Lhermitte’s sign 228, 298, 308, 323, 405 LHRH agonists 192, 211–212, 227 Libman-Sacks endocarditis 52, 279 Lichen planus 132, 362–363 Li Fraumeni syndrome 190, 204, 225, 297 Ligament tear 273, 295 Light chain deposition disease 69–70, 178, 421 Light’s criteria 11 Likelihood ratio 417 Linitis plastica 197 Lipase 26–27, 62, 114, 116, 125, 129, 136, 139, 196–197, 199, 204–205, 213, 259–260, 339, 404 Lithium toxicity 104 Livedo reticularis 157, 280, 288, 291, 371–372, 421 Liver enzymes 103, 128, 130, 138–139, 227, 259, 262, 277, 409 Liver failure acute 128–130 chronic 132–135 encephalopathy 128–129, 132–133, 135 fulminant 128–129 hepatitis B 129–130 hepatitis C 129, 131, 262 jaundice .128, 130–131, 133 Liver metastases 201, 203, 207, 391 Liver transplant 12, 103, 119, 129, 132–137, 139, 206 Lobular carcinoma in situ (LCIS) 189, 191 Lofgren’s syndrome 276–277, 279, 282, 420 Long thoracic nerve 330 Lower GI bleed 120 Lower GI bleed 120 IBD 120 Lower motor neuron 228, 285, 303, 307, 333 Low molecular weight heparins (LMWH) 9–10, 29–30, 89, 100, 152, 155–156, 159–161, 410–411, 415, 425 Lumbar puncture 100, 167–169, 176–177, 235, 239, 242–244, 260, 264, 267, 307–308, 310, 313–314, 322, 327, 329, 380, 382 Lumbosacral radiculopathy 285 Lung abscess 6, 8, 12, 374 Lung cancer 12–13, 20–21, 185–187, 220–221, 228, 261, 318–319, 347, 350, 374, 394, 411, 418–419 Lung cavities 20 Lung metastases 370 Lung resection assessment 424 Lupus 8–9, 69–70, 75, 79, 154–157, 233–234, 242, 279–281, 292, 322, 362, 365, 371–372, 415, 420 in pregnancy 415 Lyme disease 34, 112, 173, 234–236, 239, 276–277, 282, 308 Lymphadenopathy 10, 13–14, 53, 144, 146, 149, 151, 167, 169–174, 177–178, 219–220, 233, 235, 237, 239–241, 246, 250, 259, 262, 266, 277, 279–280, 345, 348, 420–422 Lymphoblastic lymphoma 167, 169, 174, 176–177 Lymphocytosis 16, 124, 170–172, 174, 308 Lymphoma definition 167 Hodgkin’s 149, 163, 167, 169–174, 181, 261, 318 non-Hodgkin’s 149, 167, 169–171, 173–178, 227–228, 259–260, 361, 403 small lymphocytic 167, 170, 173 Lymphoplasmacytic lymphoma 170, 174, 178 M Macrocytic anemia 105, 145–147 Macrolides 7, 63, 100, 114, 255, 257, 365 Malabsorption 83, 124–126, 163, 327, 352, 354–355, 405, 407, 421–422 Malaria 138, 145, 152, 164–165, 236, 238–240 Malar rash 279–280, 371 Malignant hypertension 57, 68, 151 Malignant pleural effusion 186–187, 220 Malnourishment 125, 406 Mammogram 158, 190–191, 219, 223, 225 Management 1–7, 9, 11–19, 11–121, 26, 28–30, 33, 37, 39, 41–42, 48, 50–52, 54, 56, 58, 61, 68–70, 74–76, 78–84, 93–94, 99–102, 104–106, 108–109, 111, 113–114, 117, 123–124, 126, 129, 131–132, 134, 136–139, 143–151, 153, 155–157, 159, 165–171, 173, 175–176, 180, 187–189, 191–192, 195–196, 198–200, 202–206, 208–209, 211, 214, 216–220, 230–231, 234–235, 237, 243, 245, 247, 249, 251, 260–261, 264, 274–275, 277–278, 280, 283–284, 286, 288–289, 298, 302–303, 307–312, 314, 316–317, Index 452 319–320, 322, 327–328, 333–340, 342–343, 345–353, 355, 357–358, 361–362, 364, 366–367, 369–372, 374–375, 377–378, 380, 382–385, 389, 392, 394–398, 403–407, 409–410, 412–413, 419, 422–425, 429 principles 429 Mantle cell lymphoma 170, 173–174, 177 Marantic endocarditis 52 Marasmus syndrome 126 Marginal zone lymphoma 170, 173–174 Mastectomy 191–192, 219, 225, 415 Maternal Medicine .409 McDonald criteria multiple sclerosis 308 Mechanical back pain 284 Mechanical heart valve 157 Mechanical ventilation 1–2, 4, 19, 89, 93–95, 97, 99–100, 329, 399, 425 Median nerve 325, 327–328, 331 Mediastinal lymphoma 174 Mediastinal masses 21, 112, 169, 171–172, 177 Medical fitness to drive 426–427 Medication induced headaches 202, 236, 287, 298, 412 Medications 1–2, 8, 10, 13, 15–18, 29, 31–34, 39–40, 50–53, 55, 57, 61, 67–68, 75, 81, 94–95, 97–98, 101–102, 106–108, 113–115, 118, 120, 122–126, 130–133, 135, 138–139, 143–146, 148–149, 151, 153, 173, 202, 230, 233–234, 237, 239, 252, 257, 260, 270, 273, 280, 288, 306, 311–315, 318, 320, 322, 337, 341, 343–344, 346, 349, 352, 354–355, 357, 363–364, 373, 377–378, 382–383, 385–386, 390–392, 395–397, 400, 405, 407, 409, 412–414, 421, 424–426, 429 in pregnancy 412–414 Mediterranean fever 115, 233, 241, 276–277, 282 Medullary cystic kidney disease 75–76 Medullary sponge kidney 75–76, 84 Medullary syndromes 306 Melanoma 20, 32, 159, 170, 173, 181, 195, 204, 219, 225–227, 261, 297, 299, 348, 353, 367–371 Melena 118, 120, 197 Membranoproliferative glomerulonephritis (MPGN) 68, 70, 72, 75, 130, 132, 170, 421 Membranous glomerulonephritis (MGN) 68, 70–71, 280 Meniere’s disease 315–317 Meningitis 79, 81, 97, 135, 147, 176, 235, 240–244, 246, 257, 260, 263, 265, 267, 280, 291, 305, 309–310, 313, 317, 378, 380–382, 422 Meningitis 79, 81, 97, 135, 147, 176, 240–244, 246, 257, 260, 263, 267, 280, 291, 305, 309–310, 313, 315, 317, 378, 380–382, 422 LEPTOMENINGEAL 176 Meniscal tear 286, 295 Mesothelioma 21, 32, 188, 220, 226, 228, 374 Metabolic acidosis 3, 8, 19, 33, 74, 77–78, 82, 96, 101, 103–104, 107, 394–395 diabetic ketoacidosis 115, 338–339 Metabolic alkalosis 18, 78–79, 81, 354 Metabolic cardiomyopathy 34 Metabolic syndrome 27, 61–62, 275 Methadone conversion 393 Methanol overdose 107 Methicillin resistant Staphylococcus aureus (MRSA) 6, 8, 54, 97, 100, 237, 247, 249–250, 253–255, 262, 269, 273 Methotrexate 68, 121, 146, 169–170, 176–177, 181, 193, 195, 209, 226, 230–231, 260, 277–281, 283–284, 289–291, 299, 362, 366, 371–372, 415, 420 Metronidazole 7, 113–114, 117, 121–123, 136, 238, 245–246, 248, 255, 257–258, 364, 386, 413 Micafungin 266, 268 Microangiopathic hemolytic anemia (MAHA) 68, 151–152, 163, 409 Microcytic anemia .144 Microscopic polyangiitis (MPA) 72, 288–289, 291, 293 Mid-systolic click 44, 52 Migraines 59, 299, 309, 313–315 Migrainous vertigo 316 Minimal change disease (MCD) .68–72, 172 Mitral regurgitation 27, 33–34, 38, 43–46, 48, 51–52 Mitral stenosis 3, 12, 35, 38, 42, 44–47, 49–51, 312, 411, 422, 424 Mitral valve prolapse 45–47, 51–53, 76 Mixed connective tissue disease 32, 279–281, 292 Mixed hypertriglyceridemia 62 Modified Duke’s criteria 53 Monoarthritis gout 273 septic arthritis 273–274 Monobactam .254 Monoclonal antibodies 227, 278, 309 Monoclonal gammopathy 170 Monoclonal gammopathy of undetermined significance (MGUS) 179–180, 327 Mononeuritis multiplex 289, 291, 327, 329, 337 Mononeuropathy 291, 327, 332, 337 Morphine 29, 33, 37, 79–80, 84, 89, 117, 139, 147, 153, 231, 392–393 Motor Cortex 310, 332 MR angiography 56, 333 MRI head 10, 80, 143, 176, 298, 302, 307–308, 310, 314–316, 322, 333 MR venography 333 Mucosa associated lymphoid tissue (MALT) 173–174, 176–177 Mucositis 112, 181–182, 199, 226–227, 230–231, 397–398 treatment 181, 230–231, 398 Multiple endocrine neoplasia (MEN) syndromes 201, 245, 345, 349 Multiple myeloma 69, 73–74, 78, 145, 170, 178–181, 227–228, 233, 261, 284, 288, 353, 403 Multiple sclerosis 107, 111–112, 126, 243, 287, 306–309, 315, 317, 320, 328, 332–333, 378, 396 Multi-system disorders 420 Murmurs diastolic murmurs 25, 46–47, 49 innocent 47 maneuvers 35, 45–46, 48 systolic murmurs 45–47, 51–52 Muscle strength grading .332 Myasthenia gravis (MG) 18, 21, 89, 112, 189, 306–308, 318–319, 332, 333, 343, 410 thymoma .21, 189, 318–319 Mycobacterium avium complex (MAC) 123, 164–165, 259–262 Mycosis fungoides 174, 177, 361–362 Myelodysplastic syndrome 146, 165, 168, 181, 233 Myelofibrosis (MF) 143, 150, 163–167 Myelopathy 89, 278, 298, 308, 323, 422 Myeloproliferative disorders chronic myelogenous leukemia .100, 150, 165–166 essential thrombocytosis 165–166 polycythemia rubra vera 143, 150, 156, 165–166 Myocardial infarction peri-operative 59, 147, 424 posterior infarction 30 right ventricular infarction 29–30 territory 64 Myoclonus 102, 309, 320, 322, 392–393 Myopathy 18, 61, 83, 89, 105, 126, 128, 281, 287, 332–333, 343–344, 350 Myotomes 324–325, 333 N Narcolepsy .17–18, 309 Narrow complex tachycardia 40, 63 Nausea and vomiting adrenal insufficiency 111, 349 chemotherapy-induced 229–230 palliative setting 395–396 Neck stiffness 233–234, 237, 239, 242 Necrotizing enterocolitis .238 Necrotizing fasciitis 97, 158, 247–248, 253, 258 Necrotizing pancreatitis .139 Needle stick injury 261, 269–270 Negative predictive value 417 Negligence 426, 428 Index Nephritic syndrome 70–71, 74–75, 132, 137, 280 Nephrotic syndrome 10, 61, 69–72, 74, 79, 132, 156, 280, 343, 352 Nerve roots 285, 303, 323, 325–327, 332 Neurocardiogenic syncope 312, 382 Neuroendocrine tumors 124, 201–202, 219, 225 Neurogenic claudication 284–285 Neurogenic syncope 310, 312, 382 Neuroimaging 301, 313, 333–334 Neuroleptic malignant syndrome (NMS) 101–102, 241, 332, 426 Neuropathy 18, 27, 42, 54, 73, 89, 105, 124, 126, 132, 145–146, 172, 178, 180, 185, 193, 215, 227, 235, 247–248, 252, 261, 278–280, 288–291, 313, 319, 323, 327–333, 337–338, 340, 367, 384, 396–397, 405, 420–421, 427 Neutropenia 132, 148, 168, 170, 180–181, 193, 228–230, 236–238, 266, 268–269, 278–279 febrile 148, 168, 170, 180–182, 193, 228–230, 236–238, 269 Neutropenic fever 148, 233, 237–238, 266, 406 New York heart association (NYHA) classification 27, 35, 37–38, 90, 275, 411, 422, 426 Niacin deficiency 201 Nicotine addiction .418 Nikolsky’s sign .366 Non-alcoholic steatohepatitis (NASH) 42, 128, 130, 132 Non-Hodgkin’s Lymphoma 149, 167, 169–171, 173–178, 182, 227–228, 259–260, 361, 403 Non-invasive positive pressure ventilation (NIPPV) 94, 96, 395 Non-ketotic hyperosmolar hyperglycemia (NKH) 339 Non-nucleoside reverse transcriptase inhibitors (NNRTI) 252, 261 Non-seminoma 212–214 Non-small cell lung cancer 186–187 Non-ulcer dyspepsia 113–114 Normal pressure hydrocephalus (NPH) 315, 322, 341–342, 378, 380, 382–383, 414 Normocytic anemia .73, 145 Nosocomial infections 269 Nosocomial pneumonia 6–7, 100 NSAIDs-induced gastropathy .114 NSAIDs-induced renal failure 69 Nucleoside reverse transcriptase inhibitors (NRTI) 252, 261 Number needed to treat (NNT) 303, 418 Numbness multiple sclerosis 303, 337 stroke/TIA 304, 316 Nutrition 8, 85, 96, 105, 121–122, 126, 129, 139, 237, 265, 354, 377, 382, 390, 398, 403–404, 406–407 453 O Obesity 1, 8, 17–18, 21, 23, 27, 30, 34, 36, 40–41, 43, 56–57, 61, 72, 94, 114, 117, 130, 133, 195, 198, 204, 207, 216, 247, 275, 286, 292, 314, 338, 340, 348, 350, 352, 357, 367, 384, 403, 406, 409, 413, 423 Obscure GI bleed .120 Obstetrical medicine 152, 412 Obstructive lung disease 134, 147, 424 Obstructive sleep apnea 17–18, 94, 143, 403 Obturator nerve 326, 331, 337 Occult GI bleed 12, 118–120, 144–145 Octreotide 119, 129, 135, 202, 231, 311, 342, 347, 396 Oculocephalic reflexes 91 Oculomotor nerve lesions 305 Odds ratio (OR) 418 Opening snap 44–46, 49–50 Opiate overdose 103, 105 Opioid Use 127, 392, 396 Optic atrophy 290, 306, 319, 344, 405 Optic neuritis 185, 252, 306, 308–309 Oral airways 95 Oropharyngeal dysphagia 112–113 Orthostatic proteinuria 74–75 Oseltamivir 264–265 Osler nodes 53 Osmolar gap 77, 101–102, 104, 107 Osteitis fibrosa 73 Osteoarthritis (OA) 273, 275–276, 278, 285–286, 347, 353, 403 Osteomyelitis 10, 53, 147, 233, 248–249, 256, 258, 265, 273, 338 Osteoporosis 19, 59, 124, 139, 160, 181, 192, 212, 227, 350, 353–355, 377, 383, 392, 418 Osteoporosis risk assessment instrument 355 Ovarian ablation 192–193 Overdose acetaminophen 103, 128 digoxin 38–39, 382 opioids 392 Overflow incontinence 384 Overlap syndrome 279, 332 Oxaliplatin 196, 198–200, 226, 230 Oxazolidinones 255 Oximetry 58, 91–92, 99, 104, 143 Oxygen saturation gap 104 P Paclitaxel 29, 31, 187, 193–194, 216, 218–220, 226, 230–231 Pain control .28, 84, 96, 117, 147, 205, 231, 284–285, 287, 314, 356, 391–393, 395–397, 411, 415, 424 Palindromic rheumatism 273, 276–278, 282 Palliative dyspnea 53, 188–189, 199, 202, 209, 389, 394–395, 400 medication route 391 nausea and vomiting 111, 127, 395–396 pain control 205, 391, 395–396 sedation 395, 428 Palliative care 91, 219, 389–401, 429 Palliative performance scale (PPS) 390, 401 Palliative prognostic index (PPI) 400 Palliative prognostic score (PaP) 400 Palmer xanthoma 61–62 Palpable purpura 233, 280, 288–289, 291, 373 Palpitations atrial fibrillation 39–41, 49, 52, 108, 344 pheochromocytoma 39, 348–349 P-ANCA 13, 69, 71–72, 121, 289, 291, 293, 398 Pancoast tumor 14 Pancolitis .121–122 Pancreatic cancer 128, 138–139, 205, 220–221 Pancytopenia .147, 153, 167, 169, 181, 187, 189, 227, 266, 405 multiple myeloma .178, 181, 227 Papilledema 57, 297, 306, 314 Pappenheimer bodies 163 Papulosquamous lesions .362 Paranasal sinus lymphoma 177 Parapneumonic effusion 6, 11 Parasomnia 17 Parkinson’s disease 102, 107, 315, 320–322, 328, 379, 385 Paroxysmal hemicrania 314 Paroxysmal nocturnal hemoglobinuria (PNH) 9, 146, 153, 156–157, 167 Parvovirus B19 147, 281, 288, 291, 364–365 Pelvic inflammatory disease 115, 221, 246 Pemphigus vulgaris .365–366 Penciclovir 265 Penicillin allergy 114, 257, 373 Penicillins 15, 32, 51, 54, 68, 114, 123, 146, 148–149, 233–234, 240, 243, 246–248, 253–254, 257–258, 270, 288, 365, 372–373, 380, 413, 426 Peptic ulcer disease (PUD) 25–26, 111, 113, 115, 118–120, 125, 220, 280, 353 Percutaneous coronary intervention (PCI) 26, 29, 31, 144, 423–424 Performance status 175, 177, 186–188, 194, 196, 198, 200, 208, 216, 237, 298, 390, 397, 400 Pericardial effusion 3, 8, 32–33, 146, 168, 186, 188, 278, 343, 394 Index 454 Pericarditis 6, 25–28, 30–33, 40, 43–44, 51, 53, 64, 68, 134, 136–137, 164, 181, 266, 278–279, 281, 303, 422 Peri-operative assessment 422–425 Perioral dermatitis .363–364 Peripartum cardiomyopathy 411 Peripheral blood smear 143, 163, 168 Peripheral nerves 297, 303, 325–327, 329–332 Peripheral neuropathy 54, 73, 105, 132, 145–146, 178, 215, 227, 235, 252, 279–280, 288–289, 291, 319, 323, 327–332, 338, 367, 384, 405, 420–421 Peripheral vascular disease 54–56, 59, 247, 337–338, 367 Peritoneal carcinomatosis 220, 398 Peritonitis 86, 115–117, 135–137, 221, 238, 246, 258 Peroneal nerve 323, 326, 331, 347 Pheochromocytoma 34, 39, 57, 60, 143, 201, 208, 225, 233, 281, 337, 348–349 Photophobia 42, 283, 314, 316 Photosensitivity 43, 226–227, 273, 279–280, 292, 364, 371–372 Pigmented lesions .368 Pink puffer Pitting edema 35, 55, 158, 283 Pituitary tumors 346, 349, 351–352 Pityriasis rosea .362 Plasma cell dyscrasias 178 Platelet activation pathway 154 Platinating agents .226 Pleural based disease 21 Pleural effusion 3, 7–12, 16, 18, 21, 25–26, 31, 33, 36, 40, 64, 86, 100, 134, 186–188, 195, 215, 220, 241, 250, 278–279, 281, 343, 394–395, 422 Plummer-Vinson syndrome 144, 195 Pneumocystis jirovecii pneumonia (PJP) 16, 20, 92–93, 227, 255, 259–262, 413 Pneumonia 3, 5–8, 10–12, 15–16, 19–20, 25–26, 33, 36, 38, 42, 47, 52–53, 79, 89, 92–93, 97, 100, 105, 108, 111, 113–115, 125, 135, 139, 146–149, 187, 236, 238, 241–243, 252–253, 257–260, 262–264, 266–267, 269, 279, 300, 310, 365, 374, 380–382, 394, 406, 410, 418, 425–426 recurrent Pneumonia severity of illness score (PSI) 6–7 Podagra .275 POEMS syndrome 178, 180 Polyarteritis nodosa (PAN) 68–69, 130–131, 233, 288, 291, 308 Polyarthritis fever 51, 122, 277, 283, 365, 422 rheumatoid arthritis 277, 279 seronegative spondyloar thropathies 283 systemic lupus erythematosus 279 Polycystic kidney disease 57, 73–76, 143, 207, 244 Polycystic ovarian syndrome (PCOS) 356–358, 364, 413 Polycythemia rubra vera (PRV) 143, 150, 156, 164–167 Polymyalgia rheumatica 273, 276–277, 282, 289–290, 292 Polymyositis 89, 101, 204, 273, 277, 279–282, 292–293, 332–333, 397 Polyneuropathy 42, 89, 180, 291, 327, 333, 337 Polypharmacy 377, 385 Polyuria diabetes insipidus 81, 347 diabetes mellitus 338 hypercalcemia .81, 178, 229, 347, 353 Porphyria .79, 115, 132, 309, 357, 365, 371–372, 420–421 Porphyria cutanea tarda 365, 372, 421 Portal hypertension 12, 14, 60, 133–135, 137, 164, 206, 278 Portal vein thrombosis 136 Portopulmonary hypertension 134 Poser criteria 308 Poser criteria for multiple sclerosis 308 Positive predictive value .417 Posterior infarction 30 Posterior pituitary deficiency .347 Post nasal drip 1, 12 Postpartum thyroiditis 344, 414 Post-test probability 417 Post transfusion purpura (PTP) 162 Post transplant lymphoproliferative disorders (PTLD) 174, 177 Postural proteinuria 75 Power of attorney 378, 390 Precordial examination 44 Preeclampsia 152, 409–410, 412, 414–415 Pregnancy 8–10, 19, 30, 34, 39, 42, 45, 51, 58, 60, 70, 102, 105, 111, 115, 128, 138, 151–152, 156–159, 187, 192, 218, 221, 244–246, 251–252, 261, 270–271, 280, 292, 311, 328, 337, 345–346, 356–357, 366–367, 409–415 Pre-operative workup 196 Pre-test probability 8, 417 Priapism .147 Primary biliary cirrhosis (PBC) 128, 132–133, 138, 148, 281, 343, 354, 361 Primary CNS lymphoma 174, 176 Primary sclerosing cholangitis (PSC) 121, 128, 132, 138–140, 223, 283 Primitive reflexes 304, 378–379 Proctitis 121–122 Progesterone challenge test 357 Prognostication 211, 400–401 Prolactinoma 346–347, 356–357 Prolonged QT interval 352 Prolymphocytic leukemia 170 Prophylaxis asplenic patients 147–148 hepatitis B 239, 261, 269 HIV .259, 261, 269–270 neisseria meningitides 152, 269 traveler 239–240, 270 Proprioception changes 246, 306, 308, 315, 320, 382, 405 Prostate cancer 210–211, 220, 222, 224, 228, 383, 400 Prostate specific antigen (PSA) 158, 210–212, 219–220, 222, 353, 398 Prosthetic joint infections 250 Protease inhibitor (PI) 5, 252, 261, 269, 337 Proteinuria 57–59, 70–76, 179, 187, 208, 227, 240, 279–280, 337, 340, 409, 420–421 Pruritus 73, 132, 138–139, 143, 165, 172, 174, 203–204, 235, 239, 361, 363, 392, 411–412 Pseudo-exacerbation 308 multiple sclerosis 308 Pseudogout 273–277, 282 Pseudomembranous colitis 123 Pseudomonas 5–7, 12, 97, 234, 236, 241, 247, 253, 258, 273 Pseudo-renal failure 69 Pseudotumor cerebri 243, 313–314, 403 Psoriasis vulgaris 362–363 Psoriatic arthritis (PA) 11, 19, 20, 32, 98, 273, 275–277, 282–284, 304, 363, 409 Ptosis 14, 189, 304–306, 318–319 Pulmonary embolism (PE) 1, 3–4, 8–12, 15, 19, 21, 23, 25–26, 28, 33, 37–38, 40, 42–44, 53, 64, 92–93, 97, 143, 156, 157–161, 279, 300, 312, 394, 410, 425–426 Pulmonary eosinophilia .149 Pulmonary function test 2, 5, 21–23, 424 Pulmonary hypertension 3–4, 8, 12, 14–17, 21, 23, 25, 33, 35, 37, 43–44, 49–52, 92, 98, 134, 147, 158, 279, 281, 312, 394, 403, 411 Pulmonary regurgitation 45–47, 49, 201 Pulse 15, 25, 34, 36, 38, 40, 43–44, 46–47, 49–50, 55–56, 72, 90–91, 104, 118–120, 180, 289–290, 312, 368 irregularly irregular 43 Pulseless disease 289 Pulse pressure 36, 43, 46–47, 49 wide 43, 49 Pulsus alternans 43 Pulsus paradoxus 1, 3, 32–33, 43 Pyelonephritis 68–69, 111, 115, 178, 207, 244–245, 269, 284, 412 Pyoderma gangrenosum 121, 276–277, 282–283, 367–368 Pyridoxine deficiency 126 Q Q fever 52, 233, 235, 238–239 QT prolongation 42, 168, 302, 392 ... examination 295 Korsakoff’s amnesia .107 Krukenberg tumor .197 Kussmaul breathing 107, 395 Kwashiorkor syndrome 126 L Labral tear 295 b-lactamase resistance 253 Lactoacidosis... 422 LEPTOMENINGEAL 176 Meniscal tear 286, 295 Mesothelioma 21, 32, 188, 220, 226, 228, 374 Metabolic acidosis 3, 8, 19, 33, 74, 77–78, 82, 96, 101, 103–104, 107, 394– 395 diabetic ketoacidosis... 54–56, 59, 247, 337–338, 367 Peritoneal carcinomatosis 220, 398 Peritonitis 86, 115–117, 135–137, 221, 238, 246, 258 Peroneal nerve 323, 326, 331, 347 Pheochromocytoma 34, 39, 57, 60, 143, 201,