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NATIONAL HEART, LUNG, AND BLOOD INSTITUTE PROGENITOR CELL TRANSLATIONAL CONSORTIUM 5TH ANNUAL (VIRTUAL) MEETING THE UNIVERSITY OF ALABAMA AT BIRMINGHAM SEPTEMBER 29–30, 2021 5th Annual PCTC Meeting Table of Contents Welcome Acknowledgments .3 Overview of the PCTC PCTC Committees Funding Opportunities List of Funded PCTC Awards to Date Keynote Speakers 11 Agenda 13 Breakout Room Assignment of Abstracts 16 Abstracts 19 Chapman (UCSF) Research Hub 01 20 Chou (CHOP) Research Hub 02 25 Daley (BCH) Research Hub 03 30 Snoeck (CUMC) Research Hub 04 .34 Thomson (UW-M) Research Hub 05 40 Whitsett (CCHMC) Research Hub 06 46 Zhang (UAB) Research Hub 07 52 U01 Research Hub Principal Investigators .59 Meeting Participants 62 Networking and Collaboration by Registration Institution 74 Index 115 Birmingham Civil Rights Institute (Virtual Visit) 132 https://translationalcells.org 5th Annual PCTC Meeting Welcome bringing their discoveries to improve public health Dear Friends and Colleagues, On behalf of the Department of Biomedical Engineering at the University of Alabama at Birmingham (UAB), and the Zhang Research Hub of the NHLBI Progenitor Cell Translational Consortium (PCTC), we warmly welcome you to the Fifth Annual PCTC (Virtual) Meeting While we hoped to host you in person in Birmingham to explore our campus and the city together, we have organized this virtual meeting to provide an accessible forum to promote collaborative interaction As PCTC investigators, we look forward to reviewing the past year’s progress and establishing plans for the future in these truly historic times We hope this meeting will provide a stimulating environment for all attending investigators and trainees in the fields of heart, lung, and blood research to foster lively discussions that will catalyze progress and promote future research This year we are excited to welcome keynote speaker Eric Olson, Ph.D., Chair of the Department of Molecular Biology at the University of Texas Southwestern Medical Center in Dallas; and Robert Langer, Jr., Sc.D., Institute Professor, Chemical Engineering and Biological Engineering, Harvard-Massachusetts Institute of Technology Both speakers will discuss the translational aspects of their research and the impact on public health of successfully The symposium’s day-and-a-half agenda will provide a stimulating environment for all investigators and trainees in the field of heart, lung, and blood, to have lively discussions that will catalyze progress and promote future collaborations This year’s Trainee’s Only Session (TOS) was organized by Asher KahnKrell, Danielle Pretorius, Eric Zhang, and Yang Zhou from the University of Alabama, and Matt Brown from the University of Wisconsin at Madison At the TOS, trainees will have the opportunity to present and interact with one another The main meeting session will allow additional trainees and junior investigators to present their research in the Plenary sessions, followed by a Breakout Session, comprising 21 abstracts We are extremely grateful to Michael Terrin, M.D., MPH, Professor, and his team at the University of Maryland School of Medicine for their tireless efforts in organizing this meeting and making it available virtually We look forward to seeing you online in September and very much hope to see you in person for our 2023 meeting Best wishes, Jianyi “Jay” Zhang, M.D., Ph.D Chair, Department of Biomedical Engineering Professor of Medicine, of Engineering School of Medicine, School of Engineering University of Alabama at Birmingham | UAB https://translationalcells.org 5th Annual PCTC Meeting Acknowledgments The University of Alabama (UAB) investigators, the National Heart, Lung, and Blood Institute (NHLBI) Progenitor Cell Translational Consortium Administrative Coordinating Center (NHLBI PCACC), and affiliated consortium investigators, organized this th Annual (Virtual) PCTC Meeting, under the leadership of Drs Denis Buxton (NHLBI Program Director of the PCTC) and Victor Dzau (Chair of the PCTC) The Consortium extends gratitude to Drs Jay Zhang, Timothy Kamp, Nenad Bursac, and their team for their generous support in organizing the annual meeting Special acknowledgment also goes to Ms Andrea Lefever (University of Maryland, Baltimore), Ms Elizabeth Casher (University of Maryland, Baltimore), Ms Tina Kramer (University of Maryland, Baltimore), Dr Yuji Zhang (University of Maryland, Name Michael Terrin Jennifer Albrecht Elizabeth Betz Andrea Lefever Ling Tang Yuji Zhang Tina Kramer Baltimore), and Ms Ling Tang (University of Maryland, Baltimore) for work on meeting logistics The Consortium further extends appreciation to Asher Kahn-Krell, Danielle Pretorius, Eric Zhang, and Yang Zhou from the University of Alabama at Birmingham, for their enthusiastic efforts in organizing and leading the Trainees Only Session (TOS) with guidance from Drs Minzhe Guo, Serine Avagyan, Matthew Brown (co-chairs of the PCTC Skills Development Committee) and from Drs Michael Terrin and Jennifer Albrecht (University of Maryland, Baltimore) Please direct any questions or concerns that may arise in planning your participation in the 5th Annual (Virtual) PCTC Meeting to the staff of the PCTC Administrative Coordinating Center: Title Contact Principal Investigator Multiple Principal Investigator Senior Accountant (Awards/Grants) Research Supervisor Research Project Coordinator Bioinformatician/Co-Investigator Research Project Coordinator https://translationalcells.org Email mterrin@som.umaryland.edu jalbrecht@som.umaryland.edu eensbren@som.umaryland.edu alefever@som.umaryland.edu litang@som.umaryland.edu yuzhang@som.umaryland.edu tkramer@som.umaryland.edu 5th Annual PCTC Meeting Overview of the PCTC Purpose The goal of the NHLBI Progenitor Cell Translational Consortium (PCTC) is to translate advances in progenitor cell biology towards application to heart, lung, and blood diseases The initiative will focus on the use of progenitor cell-based disease models to understand disease mechanisms and to develop novel therapies, and the application of progenitor cell-based therapies for the treatment of heart, lung, and blood diseases Research Objectives and Scope Stem cell research promises major new insights and therapeutic approaches for human disease of the heart, lungs, and blood, but critical barriers to effective translation exist, many of which entail shared challenges among these distinct organ systems The NHLBI has provided significant support for the development of the progenitor cell biology field through the NHLBI Progenitor Cell Biology Consortium (PCBC) and the Lung Repair and Regeneration Consortium (LRRC) The PCTC will leverage the advances in progenitor cell biology made by the PCBC and LRRC and the broader scientific community Scientists have made significant progress in applying bioengineering to heart, lung and blood diseases, developing organs-on-a-chip and developing decellularized scaffolds for tissue replacement The use of patient-specific induced pluripotent stem cells (iPSCs), bioengineering and genome editing offers unique opportunities for developing personalized disease models and tissues for regenerative medicine Coupling multiple organ chips together may offer unique opportunities in drug discovery Advances in 3D printing also offer exciting new opportunities for regenerative medicine, including incorporation of vascular scaffolds into bioengineered tissues and organs In translating advances in progenitor cell biology to treat specific cardiovascular, pulmonary, or hematologic diseases, the selected disease area may involve more than one organ system, e.g., pulmonary arterial hypertension; and other areas of expertise, e.g., large animals, bioengineering, genome editing, transplant immunology, systems biology, bioreactors for scale-up of cell production and product development Focus areas include the continued development of patient-specific disease models using progenitor cells and genome editing; the use of progenitor cells (including gene modified progenitors) and their differentiated progeny for cell therapy and tissue engineering; the development of strategies to promote the reparative potentials of endogenous progenitor cells; and expansion of efforts to employ direct reprogramming of cells in vivo to treat disease When needed to inform translational potential and strategies, studies may further elucidate disease mechanisms, e.g., obtaining a better understanding of the principles governing how terminally differentiated cells re-enter the cell cycle to proliferate Modeling and therapeutic development for rare diseases are encouraged For different diseases the starting point on the translational continuum varies, and this influences how far towards clinical implementation investigators can anticipate to progress during a seven year period Projects may vary substantially in their objectives and scope of research Collaborations: The consortium will leverage shared expertise in tools and technologies, as well as intellectual insights The requirement for collaboration will be an integral part of the PCTC The program may leverage regulatory support from the new Production Assistance for Cellular Therapies (PACT) program so that https://translationalcells.org 5th Annual PCTC Meeting investigators are well informed about the specific long term needs for their project to be translatable, e.g., advice on standard operating procedures, Good Laboratory Practices, and interactions with the FDA to develop IND and IDE applications; investigators will be expected to obtain regulatory advice early in the project, consult frequently with their advisors to ensure that unforeseen regulatory barriers not arise, and report on them to NHLBI Consortium Structure The PCTC is a highly interactive and synergistic Consortium of investigators who share ideas, data and resources to advance Victor Dzau, MD CHAIR OF THE PCTC PRESIDENT, NATIONAL ACADEMY OF MEDICINE https://translationalcells.org translation of progenitor cell biology In addition to interactions within a Research Hub, extensive collaboration among Research Hubs is expected and may include collaborations between investigators at multiple institutions The Consortium consists of Research Hubs, and an Administrative Coordinating Center (ACC), responsible for enabling collaboration across the consortium through logistical support and a variety of tasks The ACC administers funds to support Research Hub collaborations, translation to clinical applications, and skills development activities The NHLBI works in partnership with the Research Hubs and ACC under cooperative agreements Denis Buxton, PhD NHLBI REPRESENTATIVE ASSOCIATE DIRECTOR BASIC AND EARLY TRANSLATIONAL RESEARCH PROGRAM 5th Annual PCTC Meeting PCTC Committees STEERING COMMITTEE ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ Victor Dzau (Chair) Denis Buxton (Co-chair) Nenad Bursac Hal Chapman Stella Chou George Q Daley Deborah French Timothy Kamp Darrell Kotton Jeffrey Lipton Edward Morrisey Igor Slukvin Hans Snoeck Michael Terrin James Thomson Adrianna Vlachos Gordana VunjakNovakovic Jeffrey A Whitsett Jay Zhang Leonard Zon SKILLS DEVELOPMENT ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ Serine Avagyan (Co-chair) Matthew Brown (Co-chair) Minzhe Guo (Co-chair) Jaymin Kathiriya Asher Kahn-Krell John Leach Terren Niethamer Danielle Pretorius Michael Terrin Jennifer Albrecht Eric Zhang Yuji Zhang Yang Zhou ‘OMICS COMMITTEE ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ Deborah French (Chair) Jake Chen Minzhe Guo Areum Han Jaymin Kathiriya Hans Snoeck John Snowball Ron Stewart Michael Terrin Carlos Villacorta Song Yang Yuji Zhang Yang Zhou https://translationalcells.org 5th Annual PCTC Meeting Funding Opportunities Jump Start Awards - $25,000 The PCTC Jump Start Award Program offers up to $25,000/award for new technologies to overcome translational research challenges; or, preliminary data for a new translational research goal; or inter–hub collaboration Link: Apply for a PCTC Jump Start Award! Next submission deadline: March 1, 2022 Clinical Translation Awards (CTAs) - $200,000 The goal of the NHLBI Progenitor Cell Translational Consortium (PCTC) is to translate advances in progenitor cell biology towards application to heart, lung, and blood diseases The initiative will focus on the use of progenitor cell-based disease models to understand disease mechanisms and to develop novel therapies, and the application of progenitor cell-based therapies for the treatment of heart, lung, and blood diseases Funding amount - $100,000/year for up to two years More details, click HERE Visiting Scholar Awards (VSA) - $25,000 This Request for Proposals provides funding for PCTC Visiting Scholar Awards up to $25,000 for collaboration and exchange of expertise among PCTC Research Hubs The PCTC Visiting Scholar Award aims to stimulate innovative collaborations among PCTC Research Hubs along the translational research continuum Applicants will travel to PCTC Research Hub laboratories to learn new techniques, exchange scientific knowledge or perform collaborative experiments to advance translational progenitor cell-based therapies for the treatment or diagnosis of heart, lung, or blood diseases Link: Apply for a Visiting Scholar Award https://translationalcells.org 5th Annual PCTC Meeting List of Funded PCTC Awards to Date Visiting Scholar Awards Awardee Jaymin Kathiriya Research Hub Affiliation Chapman (UCSF) RH 01 Title PCTC Visiting Scholar Award Program Clinical Translation Awards Awardee Adrianna Vlachos Adrianna Vlachos Paritha Arumugam Co-PI: Bruce Trapnell Paritha Arumugam Co-PI: Bruce Trapnell Research Hub Affiliation Title Daley (BCH) RH 03 Designing a Phase I/II Dose Escalation, Toxicity/Efficacy Trial of L-leucine in DBA Daley (BCH) RH 03 A Multi-Center, Phase I/II, Dose Escalation Clinical Trial of L-leucine in Patients with Diamond Blackfan Anemia Whitsett (CCHMC) RH06 Whitsett (CCHMC) RH06 Translating Gene/ Pulmonary Macrophage Transplantation Therapy from Mouse to Man (RFP PCTC 2019 Clinical Translational 01) Translating Gene/ Pulmonary Macrophage Transplantation Therapy from Mouse to Man (RFP PCTC 2021 Clinical Translational 01) https://translationalcells.org 5th Annual PCTC Meeting Last Name Hudock 120 First Name Maria Session Breakout Abstract Title Quantitative Analysis of Cystic Fibrosis Lung Matrix Jain Mehul Plenary Targeted Activation of ERK via BRAFV600E Expression Drives Proliferation and Functional Changes in Neonatal Rat Cardiomyocytes Jha Deepak Breakout Human Pluripotent Stem Cell-Derived T Cells For Cancer Immunotherapy Jha* Deepak Plenary Jiang Peng Breakout Jing* Ran Breakout Role of Transposable Elements in Hematopoiesis and Cancer Identifying Transcriptomic Signatures and Decomposing Cellular Subpopulations of Occluded and Patent Cellularized Expanded Polytetrafluoroethylene Arterial Grafts in Rhesus Macaques Human Pluripotent Stem Cell-Derived T Cells For Cancer Immunotherapy Biomanufacturing of Micro Myocardial Tissue Through Suspension Differentiation with Improved Yields, Purity, and Quality Transendocardial Injected Human Pluripotent Stem Cell Derived Cardiac Progenitor Cells Engraft and Differentiate without Associated Tachyarrhythmias in a Swine Ischemic Cardiomyopathy Model Abstract # Page # 14 37 30 56 10 32 31 18 42 10 32 28 54 31 57 Kahn-Krell* Asher Breakout Kamp Timothy J Breakout Kaslow Sarah R Breakout Quantitative Analysis of Cystic Fibrosis Lung Matrix 14 37 Kaslow Sarah R Breakout Ex vivo Lung Repair on Crosscirculation 15 38 Kaslow* Sarah Plenary 12 35 Kathiriya Jaymin Breakout 21 Kathiriya Jaymin J Breakout 24 Kathiriya* Jaymin J Plenary 22 Keogh MichaelChristopher Plenary 31 A Clinically Relevant Model of Acute Respiratory Distress Syndrome in Human-sized Swine TGFβ-dependent Regulation of sFRP2 Expression in Fibroblasts in Human Fibrotic Lung Tissue Secreted Frizzled Related Protein Contributes to the Transdifferentiation of Human Alveolar Epithelial Type II Cells Human Alveolar Type Epithelium Transdifferentiates into Metaplastic KRT5+ basal Cells Role of Transposable Elements in Hematopoiesis and Cancer https://translationalcells.org 5th Annual PCTC Meeting Last Name Kim First Name Jinho Session Breakout Abstract Title Ex vivo Lung Repair on Crosscirculation Kim* Ji Wook Breakout GCSF Induced Mobilization of Hematopoietic Stem and Progenitor Cells from the Embryonic Hematopoietic Niche Klein Joshua Breakout Investigating the Role of KLF1 in Primitive and Definitive Erythropoiesis Koniski Anne D Breakout Koonce Chad Breakout Kotton Darrell N Plenary Kotton Darrell N Plenary Kotton Darrell N Breakout Kotton Darrell N Breakout Kotton Darrell N Plenary Kremp Madison M Breakout Kubaczka Caroline Plenary Kubaczka Caroline Breakout Kumar Akhilesh Breakout https://translationalcells.org Self-renewing Definitive Erythroblasts Derived from Human Pluripotent Stem Cells Transendocardial Injected Human Pluripotent Stem Cell Derived Cardiac Progenitor Cells Engraft and Differentiate without Associated Tachyarrhythmias in a Swine Ischemic Cardiomyopathy Model Human Alveolar Type Epithelium Transdifferentiates into Metaplastic KRT5+ basal Cells Transplantation of Mouse Pluripotent Stem Cell Derived Distal Tip-Like Cells Into Immunocompetent Mice Generation of Human Alveolar Epithelial Type I Cells from Pluripotent Stem Cells Mechanisms of Self-Renewal and Maturation of iPSC-Derived Alveolar Epithelial Type Cells Rescue of an Interstitial Lung Disease Related Surfactant protein-C Mutation by Inhibition of the Endoplasmic Reticulum Membrane Complex Activity Klf5 Promotes Alveolar Epithelial Type Cell Lineage Commitment to Drive Lung Regeneration Role of Transposable Elements in Hematopoiesis and Cancer Human Pluripotent Stem Cell-Derived T Cells For Cancer Immunotherapy MHC-Defined Nonhuman Primate Model for the Assessment of the Immunogenicity of iPSC-Derived CD34+ Hematopoietic Progenitors Following Myeloablative HSC Transplantation Abstract # Page # 15 38 11 33 29 27 31 57 22 23 22 47 23 48 26 51 24 49 31 10 32 17 41 121 5th Annual PCTC Meeting Last Name 122 First Name Session Abstract Title SKiM: A Web Interface for Identifying Literature-based Discoveries from PubMed Abstract # Page # 19 43 31 21 22 12 35 24 Kuusisto Finn Breakout Laurent Benoit Plenary Le Saux Claude Jourdan Breakout Le Saux Claude Jourdan Plenary Leb Jay Plenary LeSaux* Claude Jourdan Breakout Li Hu Plenary Role of Transposable Elements in Hematopoiesis and Cancer 31 Liang Songjingyi Plenary Regional De-Epithelialization of the Lung in a Rat Model 16 39 Liberti William A Breakout 24 49 Liberti* Derek C Breakout 24 49 LindstromVautrin Jonathan Plenary 23 Litovsky Silvio Breakout 28 54 Liu Mavis Breakout 15 38 Livny Miron Breakout 19 43 Lyon Sarah Plenary 21 45 Maguire Jean Ann Plenary 26 Role of Transposable Elements in Hematopoiesis and Cancer TGFβ-dependent Regulation of sFRP2 Expression in Fibroblasts in Human Fibrotic Lung Tissue Human Alveolar Type Epithelium Transdifferentiates into Metaplastic KRT5+ basal Cells A Clinically Relevant Model of Acute Respiratory Distress Syndrome in Human-sized Swine Secreted Frizzled Related Protein Contributes to the Transdifferentiation of Human Alveolar Epithelial Type II Cells Klf5 Promotes Alveolar Epithelial Type Cell Lineage Commitment to Drive Lung Regeneration Klf5 Promotes Alveolar Epithelial Type Cell Lineage Commitment to Drive Lung Regeneration Transplantation of Mouse Pluripotent Stem Cell Derived Distal Tip-Like Cells Into Immunocompetent Mice Biomanufacturing of Micro Myocardial Tissue Through Suspension Differentiation with Improved Yields, Purity, and Quality Ex vivo Lung Repair on Crosscirculation SKiM: A Web Interface for Identifying Literature-based Discoveries from PubMed Generation of an Off-the-shelf Allogeneic Arterial Endothelialized Small Diameter Vascular Graft Detection of Rh Antibodies in Patient Plasma Using Customized Induced Pluripotent Stem Cell-derived Red Cells https://translationalcells.org 5th Annual PCTC Meeting Last Name First Name Session Abstract Title Generation of Functional Macrophages from SIRPα-Knockout Human Pluripotent Stem Cells Confer Superior Anti-Tumor Potential Against CD47+ Solid Tumor Cancers A Clinically Relevant Model of Acute Respiratory Distress Syndrome in Human-sized Swine Abstract # Page # 20 44 12 35 Majumder Aditi Breakout Marboe Charles Plenary Marboe Charles C Breakout Quantitative Analysis of Cystic Fibrosis Lung Matrix 14 37 Markel Arianna Plenary Role of Transposable Elements in Hematopoiesis and Cancer 31 26 51 31 22 17 41 21 45 18 42 27 24 49 Martin Emily P Plenary Rescue of an Interstitial Lung Disease Related Surfactant protein-C Mutation by Inhibition of the Endoplasmic Reticulum Membrane Complex Activity Marunde Matthew R Plenary Role of Transposable Elements in Hematopoiesis and Cancer Matthay Michael Plenary Maufort John Breakout Maufort John P Plenary Maufort* John Breakout McGrath* Kathleen Breakout Morley Michael P Breakout Morley Michael P Plenary Endothelial ATF3 Plays a Critical Role in Lung Regeneration 25 50 Morris Vivian Plenary Role of Transposable Elements in Hematopoiesis and Cancer 31 https://translationalcells.org Human Alveolar Type Epithelium Transdifferentiates into Metaplastic KRT5+ basal Cells MHC-Defined Nonhuman Primate Model for the Assessment of the Immunogenicity of iPSC-Derived CD34+ Hematopoietic Progenitors Following Myeloablative HSC Transplantation Generation of an Off-the-shelf Allogeneic Arterial Endothelialized Small Diameter Vascular Graft Identifying Transcriptomic Signatures and Decomposing Cellular Subpopulations of Occluded and Patent Cellularized Expanded Polytetrafluoroethylene Arterial Grafts in Rhesus Macaques Self-renewing Definitive Erythroblasts Derived from Human Pluripotent Stem Cells Klf5 Promotes Alveolar Epithelial Type Cell Lineage Commitment to Drive Lung Regeneration 123 5th Annual PCTC Meeting Last Name 124 First Name Session Abstract Title Klf5 Promotes Alveolar Epithelial Type Cell Lineage Commitment to Drive Lung Regeneration Abstract # Page # 24 49 Morrisey Edward E Breakout Morrisey Edward E Plenary Endothelial ATF3 Plays a Critical Role in Lung Regeneration 25 50 Morse Michael Plenary Role of Transposable Elements in Hematopoiesis and Cancer 31 Myers Ashley Breakout 27 53 Na Cheng-Lun Plenary 26 51 Nagle Scott Breakout 31 57 Najia Mohamad Breakout Human Pluripotent Stem Cell-Derived T Cells For Cancer Immunotherapy 10 32 Najia Mohamad Plenary Role of Transposable Elements in Hematopoiesis and Cancer 31 29 55 26 51 29 28 29 55 Discovery of Cardiac Mitogens Using a CRISPR-based High-throughput Approach Rescue of an Interstitial Lung Disease Related Surfactant protein-C Mutation by Inhibition of the Endoplasmic Reticulum Membrane Complex Activity Transendocardial Injected Human Pluripotent Stem Cell Derived Cardiac Progenitor Cells Engraft and Differentiate without Associated Tachyarrhythmias in a Swine Ischemic Cardiomyopathy Model Single Nucleus RNA-sequence Analysis: Apical Resection in Newborn Pig Hearts Extends the Regenerative Cardiomyocyte Window Rescue of an Interstitial Lung Disease Related Surfactant protein-C Mutation by Inhibition of the Endoplasmic Reticulum Membrane Complex Activity Nakada* Yuji Plenary Nakayasu Ernesto S Plenary Nations Catriana C Breakout Nations* Catriana C Breakout Nguyen Thanh Plenary Niethamer* Terren Plenary Endothelial ATF3 Plays a Critical Role in Lung Regeneration 25 50 North Trista E Plenary Role of Transposable Elements in Hematopoiesis and Cancer 31 Investigating the Role of KLF1 in Primitive and Definitive Erythropoiesis Modeling Thrombocytopenia Absent Radius Syndrome Using Induced Pluripotent Stem Cells Single Nucleus RNA-sequence Analysis: Apical Resection in Newborn Pig Hearts Extends the Regenerative Cardiomyocyte Window https://translationalcells.org 5th Annual PCTC Meeting Last Name First Name Session Abstract Title Human Pluripotent Stem Cell-Derived T Cells For Cancer Immunotherapy Abstract # Page # 10 32 North Trista E Breakout O’Neill John D Breakout Quantitative Analysis of Cystic Fibrosis Lung Matrix 14 37 O’Neill John D Breakout Ex vivo Lung Repair on Crosscirculation 15 38 Olsen Jayme L Breakout 27 Palis James Breakout 27 Pavani Giulia Plenary 26 Pavani* Giulia Breakout 29 Peng Tien Plenary 22 Penkala Ian J Breakout 24 49 Petrillo* Carolina Breakout 13 36 Pinezich Meghan Plenary 12 35 Pinezich* Meghan Breakout Quantitative Analysis of Cystic Fibrosis Lung Matrix 14 37 Pinezich* Meghan Breakout Ex vivo Lung Repair on Crosscirculation 15 38 Poore Samuel O Plenary 21 45 Predella Camilla Plenary 12 35 Predella* Camilla Plenary Regional De-Epithelialization of the Lung in a Rat Model 16 39 Breakout Biomanufacturing of Micro Myocardial Tissue Through Suspension Differentiation with Improved Yields, Purity, and Quality 28 54 Pretorius Danielle https://translationalcells.org Self-renewing Definitive Erythroblasts Derived from Human Pluripotent Stem Cells Self-renewing Definitive Erythroblasts Derived from Human Pluripotent Stem Cells Detection of Rh Antibodies in Patient Plasma Using Customized Induced Pluripotent Stem Cell-derived Red Cells Investigating the Role of KLF1 in Primitive and Definitive Erythropoiesis Human Alveolar Type Epithelium Transdifferentiates into Metaplastic KRT5+ basal Cells Klf5 Promotes Alveolar Epithelial Type Cell Lineage Commitment to Drive Lung Regeneration Mitochondrial Dynamics Regulate Interferon Signaling and Age-related Changes in hPSCs A Clinically Relevant Model of Acute Respiratory Distress Syndrome in Human-sized Swine Generation of an Off-the-shelf Allogeneic Arterial Endothelialized Small Diameter Vascular Graft A Clinically Relevant Model of Acute Respiratory Distress Syndrome in Human-sized Swine 125 5th Annual PCTC Meeting Last Name 126 First Name Session Raja* Kalpana Breakout Raval Amish N Breakout Raymond Mathew Breakout Raza Naqi Plenary Reimer Jonathan A Plenary Reimer Jonathan A Breakout Reimer Jonathan A Breakout Reynolds Matt Breakout Ross Ian Breakout Roy Sushmita Breakout Ruzal-Shapiro Carrie Plenary Saito Yukhiro Breakout Abstract Title SKiM: A Web Interface for Identifying Literature-based Discoveries from PubMed Transendocardial Injected Human Pluripotent Stem Cell Derived Cardiac Progenitor Cells Engraft and Differentiate without Associated Tachyarrhythmias in a Swine Ischemic Cardiomyopathy Model MHC-Defined Nonhuman Primate Model for the Assessment of the Immunogenicity of iPSC-Derived CD34+ Hematopoietic Progenitors Following Myeloablative HSC Transplantation Single Nucleus RNA-sequence Analysis: Apical Resection in Newborn Pig Hearts Extends the Regenerative Cardiomyocyte Window A Clinically Relevant Model of Acute Respiratory Distress Syndrome in Human-sized Swine Quantitative Analysis of Cystic Fibrosis Lung Matrix Ex vivo Lung Repair on Crosscirculation MHC-Defined Nonhuman Primate Model for the Assessment of the Immunogenicity of iPSC-Derived CD34+ Hematopoietic Progenitors Following Myeloablative HSC Transplantation SKiM: A Web Interface for Identifying Literature-based Discoveries from PubMed Transendocardial Injected Human Pluripotent Stem Cell Derived Cardiac Progenitor Cells Engraft and Differentiate without Associated Tachyarrhythmias in a Swine Ischemic Cardiomyopathy Model A Clinically Relevant Model of Acute Respiratory Distress Syndrome in Human-sized Swine Transendocardial Injected Human Pluripotent Stem Cell Derived Cardiac Progenitor Cells Engraft and Differentiate without Associated Tachyarrhythmias in a Swine Ischemic Cardiomyopathy Model Abstract # Page # 19 43 31 57 17 41 29 55 12 35 14 37 15 38 17 41 19 43 31 57 12 35 31 57 https://translationalcells.org 5th Annual PCTC Meeting Last Name First Name Session Abstract Title Discovery of Cardiac Mitogens Using a CRISPR-based High-throughput Approach Targeted Activation of ERK via BRAFV600E Expression Drives Proliferation and Functional Changes in Neonatal Rat Cardiomyocytes Transendocardial Injected Human Pluripotent Stem Cell Derived Cardiac Progenitor Cells Engraft and Differentiate without Associated Tachyarrhythmias in a Swine Ischemic Cardiomyopathy Model Abstract # Page # 27 53 30 56 31 57 Scherba Jacob Breakout Scherba Jacob Plenary Schmuck Eric G Breakout Shi Yang Plenary Role of Transposable Elements in Hematopoiesis and Cancer 31 Shipp Margaret M Plenary Role of Transposable Elements in Hematopoiesis and Cancer 31 29 55 17 41 20 44 20 44 Single Nucleus RNA-sequence Analysis: Apical Resection in Newborn Pig Hearts Extends the Regenerative Cardiomyocyte Window MHC-Defined Nonhuman Primate Model for the Assessment of the Immunogenicity of iPSC-Derived CD34+ Hematopoietic Progenitors Following Myeloablative HSC Transplantation Generation of Functional Macrophages from SIRPα-Knockout Human Pluripotent Stem Cells Confer Superior Anti-Tumor Potential Against CD47+ Solid Tumor Cancers Generation of Functional Macrophages from SIRPα-Knockout Human Pluripotent Stem Cells Confer Superior Anti-Tumor Potential Against CD47+ Solid Tumor Cancers Skie Erik Plenary Slukvin Igor Breakout Slukvin Igor Breakout Smith* Portia Breakout Snoeck Hans-Willem Breakout Ex vivo Lung Repair on Crosscirculation 15 38 Snoeck Hans-Willem Plenary Regional De-Epithelialization of the Lung in a Rat Model 16 39 Snoeck Hans-Willem Breakout 13 36 Snowball John M Plenary 26 51 https://translationalcells.org Mitochondrial Dynamics Regulate Interferon Signaling and Age-related Changes in hPSCs Rescue of an Interstitial Lung Disease Related Surfactant protein-C Mutation by Inhibition of the Endoplasmic 127 5th Annual PCTC Meeting Last Name 128 First Name Session Steill John Breakout Stewart Ron Breakout Stewart Ron Breakout Strash Nicholas Breakout Strash* Nicholas Plenary Strelchenko Nick Breakout Suknuntha Kran Breakout Tamargo Manuel Breakout Tang* Xiaofang Plenary Thimraj Tania A Breakout Thomson James Breakout Thomson James Breakout Abstract Title Reticulum Membrane Complex Activity SKiM: A Web Interface for Identifying Literature-based Discoveries from PubMed Identifying Transcriptomic Signatures and Decomposing Cellular Subpopulations of Occluded and Patent Cellularized Expanded Polytetrafluoroethylene Arterial Grafts in Rhesus Macaques SKiM: A Web Interface for Identifying Literature-based Discoveries from PubMed Discovery of Cardiac Mitogens Using a CRISPR-based High-throughput Approach Targeted Activation of ERK via BRAFV600E Expression Drives Proliferation and Functional Changes in Neonatal Rat Cardiomyocytes MHC-Defined Nonhuman Primate Model for the Assessment of the Immunogenicity of iPSC-Derived CD34+ Hematopoietic Progenitors Following Myeloablative HSC Transplantation Generation of Functional Macrophages from SIRPα-Knockout Human Pluripotent Stem Cells Confer Superior Anti-Tumor Potential Against CD47+ Solid Tumor Cancers Quantitative Analysis of Cystic Fibrosis Lung Matrix Rescue of an Interstitial Lung Disease Related Surfactant protein-C Mutation by Inhibition of the Endoplasmic Reticulum Membrane Complex Activity Mitochondrial Dynamics Regulate Interferon Signaling and Age-related Changes in hPSCs MHC-Defined Nonhuman Primate Model for the Assessment of the Immunogenicity of iPSC-Derived CD34+ Hematopoietic Progenitors Following Myeloablative HSC Transplantation Identifying Transcriptomic Signatures and Decomposing Cellular Abstract # Page # 19 43 18 42 19 43 27 53 30 56 17 41 20 44 14 37 26 51 13 36 17 41 18 42 https://translationalcells.org 5th Annual PCTC Meeting Last Name First Name Session Abstract Title Subpopulations of Occluded and Patent Cellularized Expanded Polytetrafluoroethylene Arterial Grafts in Rhesus Macaques SKiM: A Web Interface for Identifying Literature-based Discoveries from PubMed Generation of an Off-the-shelf Allogeneic Arterial Endothelialized Small Diameter Vascular Graft Ex vivo Lung Repair on Crosscirculation Abstract # Page # 19 43 21 45 15 38 Thomson James A Breakout Thomson James A Plenary Tipograf Yuliya Breakout Tsoi Lam C Breakout SKiM: A Web Interface for Identifying Literature-based Discoveries from PubMed 19 43 Vaidya Anup Plenary Role of Transposable Elements in Hematopoiesis and Cancer 31 Vereide David Plenary 21 45 VillacortaMartin Carlos Plenary 23 VillacortaMartin Carlos Breakout 22 47 VillacortaMartin Carlos Breakout 23 48 VunjakNovakovic Gordana Plenary 12 35 VunjakNovakovic Gordana Breakout 14 37 VunjakNovakovic Gordana Breakout Ex vivo Lung Repair on Crosscirculation 15 38 VunjakNovakovic Gordana Plenary Regional De-Epithelialization of the Lung in a Rat Model 16 39 29 55 22 22 Walcott Gregory P Plenary Wang Bruce Plenary Wang Chaoqun Plenary https://translationalcells.org Generation of an Off-the-shelf Allogeneic Arterial Endothelialized Small Diameter Vascular Graft Transplantation of Mouse Pluripotent Stem Cell Derived Distal Tip-Like Cells Into Immunocompetent Mice Generation of Human Alveolar Epithelial Type I Cells from Pluripotent Stem Cells Mechanisms of Self-Renewal and Maturation of iPSC-Derived Alveolar Epithelial Type Cells A Clinically Relevant Model of Acute Respiratory Distress Syndrome in Human-sized Swine Quantitative Analysis of Cystic Fibrosis Lung Matrix Single Nucleus RNA-sequence Analysis: Apical Resection in Newborn Pig Hearts Extends the Regenerative Cardiomyocyte Window Human Alveolar Type Epithelium Transdifferentiates into Metaplastic KRT5+ basal Cells Human Alveolar Type Epithelium Transdifferentiates into Metaplastic KRT5+ basal Cells 129 5th Annual PCTC Meeting Last Name Session Abstract Title GCSF Induced Mobilization of Hematopoietic Stem and Progenitor Cells from the Embryonic Hematopoietic Niche Rescue of an Interstitial Lung Disease Related Surfactant protein-C Mutation by Inhibition of the Endoplasmic Reticulum Membrane Complex Activity Generation of an Off-the-shelf Allogeneic Arterial Endothelialized Small Diameter Vascular Graft TGFβ-dependent Regulation of sFRP2 Expression in Fibroblasts in Human Fibrotic Lung Tissue Single Nucleus RNA-sequence Analysis: Apical Resection in Newborn Pig Hearts Extends the Regenerative Cardiomyocyte Window MHC-Defined Nonhuman Primate Model for the Assessment of the Immunogenicity of iPSC-Derived CD34+ Hematopoietic Progenitors Following Myeloablative HSC Transplantation Detection of Rh Antibodies in Patient Plasma Using Customized Induced Pluripotent Stem Cell-derived Red Cells Rescue of an Interstitial Lung Disease Related Surfactant protein-C Mutation by Inhibition of the Endoplasmic Reticulum Membrane Complex Activity Mitochondrial Dynamics Regulate Interferon Signaling and Age-related Changes in hPSCs Human Alveolar Type Epithelium Transdifferentiates into Metaplastic KRT5+ basal Cells Generation of an Off-the-shelf Allogeneic Arterial Endothelialized Small Diameter Vascular Graft Abstract # Page # 11 33 26 51 21 45 21 29 55 17 41 26 26 51 13 36 22 21 45 Wattrus Samuel J Breakout Weaver Timothy E Plenary Webster Sarah Plenary Wei Ying Breakout Wei Yuhua Plenary Weinfurter Jason Breakout Westhoff Connie M Plenary Whitsett Jeffrey A Plenary Williams Linda J Breakout Wolters Paul Plenary Zeng Weifeng Plenary Zhang Cheng Plenary Role of Transposable Elements in Hematopoiesis and Cancer 31 Breakout Biomanufacturing of Micro Myocardial Tissue Through Suspension Differentiation with Improved Yields, Purity, and Quality 28 54 Zhang 130 First Name Jianyi https://translationalcells.org 5th Annual PCTC Meeting Last Name First Name Session Abstract Title Single Nucleus RNA-sequence Analysis: Apical Resection in Newborn Pig Hearts Extends the Regenerative Cardiomyocyte Window Single Nucleus RNA-sequence Analysis: Apical Resection in Newborn Pig Hearts Extends the Regenerative Cardiomyocyte Window Generation of an Off-the-shelf Allogeneic Arterial Endothelialized Small Diameter Vascular Graft Abstract # Page # 29 55 29 55 21 45 Zhang Eric Y Plenary Zhang Jianyi Plenary Zhang* Jue Plenary Zhou Minqi Plenary Human Alveolar Type Epithelium Transdifferentiates into Metaplastic KRT5+ basal Cells 22 Zhou Su Breakout Klf5 Promotes Alveolar Epithelial Type Cell Lineage Commitment to Drive Lung Regeneration 24 49 Zhou Su Plenary Endothelial ATF3 Plays a Critical Role in Lung Regeneration 25 50 32 58 31 57 32 58 11 33 Zhou Yang Breakout Zhou* Tianhua Breakout Zhou* Yang Breakout Zon Leonard I Breakout https://translationalcells.org Transcriptomic Comparison Identifies Distinct Molecular Features in Cardiomyocytes Generated by Different Reprogramming Approaches Transendocardial Injected Human Pluripotent Stem Cell Derived Cardiac Progenitor Cells Engraft and Differentiate without Associated Tachyarrhythmias in a Swine Ischemic Cardiomyopathy Model Transcriptomic Comparison Identifies Distinct Molecular Features in Cardiomyocytes Generated by Different Reprogramming Approaches GCSF Induced Mobilization of Hematopoietic Stem and Progenitor Cells from the Embryonic Hematopoietic Niche 131 5th Annual PCTC Meeting Birmingham Civil Rights Institute (Virtual Visit) THE BIRMINGHAM CIVIL RIGHTS INSTITUTE (BRCI) is a modern museum that serves as a connection to the Birmingham Civil Rights National Monument, a collection of sites important to the Civil Rights Movement Visitors can experience a rendition of a segregated city in the 1950s, as well as examine a replica of a Freedom Riders bus and even the actual jail cell door from behind which Dr Martin Luther King Jr penned his famous “Letter From Birmingham Jail.” The institute is also home to an expansive archive of documents from the Civil Rights Movement and nearly 500 recorded oral histories relevant to the period In addition to its permanent exhibits, the BRCI also has traveling exhibitions on the Freedom Rides, Selma-to-Montgomery marches, 16th Street Baptist Church bombing, Elder Grace, and lesbian families living in the Deep South The museum also hosts annual celebrations on landmark dates, such as Martin Luther King Jr Day and Black History Month More information at: https://civilrightstrail.com/attraction/birmingham-civil-rights-institute/ Virtual Visit (Links to short clips below): Birmingham Civil Rights Institute (1 introduction) Journey Into The Past: The Birmingham Civil Rights Institute (4 mins) 132 https://translationalcells.org ... Scholar Award Program Clinical Translation Awards Awardee Adrianna Vlachos Adrianna Vlachos Paritha Arumugam Co-PI: Bruce Trapnell Paritha Arumugam Co-PI: Bruce Trapnell Research Hub Affiliation... Blackfan Anemia Registry and as such have access to many patients for the clinical trials in DBA Full Name Photo Wade W Sugden Adrianna Vlachos https://translationalcells.org 81 5th Annual PCTC. .. analyses, a variety of markers peak at days after each passage, including AEC2 markers SFTPC and NAPSA; maturation markers SFTPA1 and SFTPA2 Conclusions: Our transcriptome-wide scRNA-seq dataset
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