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Medical
Pharmacology
at
a
Glance
MI
CHA
EL
J . N
EA
L
Professor of Pharmacology
Division of Pharmacology and T herapeutics
Kings Co llege London
The Rayne Institute
51Thoma s's Hospital
London
F
OU
RT H
ED
ITI
O N
Blackwell
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Contents
Preface 7
How to use this hook 7
Further reading 7
Introductio n:
principles of drug action 8
2 Drug
-r
ec
eptor
imeracnons 10
3 Drug absorption, distribution and excretion 12
4 Drug metabolism 14
5 Local
anaesthetics 16
fi Drugs acting at the neuromuscular junction 18
7 Autonomic nervous system 20
8 Autonomic drugs acting at cholinergic synapses 22
lJ Drugs acting on the sympathetic sys tem 24
10 Ocular pharmacolog y 26
I I Asthma, hay fever and anaphylaxis 28
12 Drugs acting on the gastrointestinal tract. l:
Peptic ulcer 30
13 Drugs acting on
the gastrointest inal tract. II: Moti lity and
secretions 32
14 Drugs acting on the kidney-cdiuretics 34
15 Drugs used in hypertension 36
16 Drugs usedin angina
3X
17 Antiarrhythmi c drugs 40
18 Drugs used in heart failure 42
19
Drugs used 10affect blood coagu lation 44
20 Lipid-lowering dru gs 46
2 1 Agents used in
anaemias 48
22 Ccnrrulrransrniue r
substances 50
23 Gene ral anaesthetics 52
24 Anx iolytics and hypnotics 54
25 Aruiepileptic drugs
5(,
26 Drugs used in Parkinson's disease 58
27 Antipsychot ic drugs (ncurolcptics) 6()
2R Drugs used in affective disorders
-antid
epre ssants 62
29 Opioid analgexics 64
30 Drugs used in nausea and vertigo (untiemetic sj 66
31 Drug misuse and dependence oR
32
Non-steroidal anti-intlamrnutory drugs ( NSAIDs) 70
33 Cortico steroids 72
34 Sex hormones and drugs 74
35 Thyroid and
antithyroid drugs 76
36 Antidia betic agents
7X
37
Antibacterial dru gs that inhibit nucleic acid synthesis:
sulphonamidcx. rrimcthoprirn. quinolones and
nitroimidazoles 80
3M
Antibacterial drugs that inhibit cell wall synthesis:
penicillin s. cephalosporins and vancomyc in X2
39
Antibacterial drugs that inhibit protein synthesis:
amin ogjycoside s. tetrac yclines, macrolidcs and
chloramphenicol 84
40 Antifungal and antiviral drugs
10:6
4 1 Drugs acting on parasites. I: Helminths (worms) 88
42 Drugs acting a ll parasites, 1I:Protozoa
(}
()
43
Drugs used in cancer 92
44 Poisoning 94
45 Adverse drug
reactions 96
Index
(}H
5
[...]... that predominates in the heart (Chapter 7).lt i, rarely used Pa ncuronlum is an uminoxtcroid neuromuscular blocking drug with a relatively long duration of action It docs nor block gangl ia or cause histamine release However it has a dose-related atropine-like effect on the heart that can produce tachycardia vecurcnlum and au-acurtu m T hese arc commonly used agents Vecuronium has no cardiovascular... apt er 17 Cardiac to xicity probably dtJt:s not occur in subc o nv ulvive d oses Yaccular smoo th musc le Th e loc al effects vary L'oc aine is a vasoconstrictor (because it hloc ks norcpincphine reuptake and potentiates sympat hetic acuvhy) hile procaine is a vasodilato r, \ 10-.1 . ch arc inhibitory.
I Pupillary dilat
ation
(more light reaches the retina).
2:
Bronchiolar dilatation rfacituatcs increased ventilation).
3 Hea rt rate and. Medical
Pharmacology
at
a
Glance
MI
CHA
EL
J . N
EA
L
Professor of Pharmacology
Division of Pharmacology and T herapeutics
Kings Co llege London
The Rayne