Clinical condition Treatment Postexposure prophylaxis Inhalational anthrax Prophylaxis for 60 days c : Ciprofloxacin 10–15 mg/kg PO q12h OR Levofloxacin mg/kg PO q12h OR Doxycycline 2.2 mg/kg PO q12h Pneumonic plague d Ricin Tularemia (pneumonic) Smallpox Ciprofloxacin 10–15 mg/kg IV q12h OR Levofloxacin mg/kg PO q12h OR Doxycycline 2.2 mg/kg IV q12h AND Clindamycin a 10–15 mg/kg IV q8h AND Penicillin G b 400–600k U/kg/d IV ÷ q4h AND consider: Raxibacumab (>50 kg: 40 mg/kg IV; 15– 50 kg: 60 mg/kg IV; 40 kg: 16 mg/kg IV) Gentamicin 2.5 mg/kg IV q8h OR Doxycycline 2.2 mg/kg IV q12h OR Ciprofloxacin 15 mg/kg IV q12h OR Levofloxacin mg/kg IV/PO q12h Supportive therapy Same as for Plague e Doxycycline 2.2 mg/kg PO q12h OR Ciprofloxacin 20 mg/kg PO q12h OR Levofloxacin mg/kg PO q12h Supportive therapy Same as for Plague e Tecoviramat 200 mg PO Vaccination may be q12h (for children 13–25 effective if given within kg); 400 mg PO q12h (for 96 hours after exposure children 25–40 kg); 600