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Andersons pediatric cardiology 2342

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summary and future directions, 1406 Complex congenital heart lesions, in diagnostic catheterization, 252 Complex double-outlet ventricle, in univentricular hearts, 1257–1258 Complex multiple pregnancies, 98–99 Compliance, arterial stiffness and, 1362t Computational fluid dynamics, for univentricular heart, 1350 Computed tomographic angiography, of anomalous aortic origin of a coronary artery, 874 Computed tomography, 317–333 of anomalies of the aortic arch, 889–891, 891f cardiac, 332–333, 332f in cardiac tumors, 968, 969f Kawasaki syndrome and, 987, 987f of pulmonary arterial sling, 893 Conal septum, 945 Concordant atrioventricular connections, 10f Conduction disturbances, following surgical correction of tetralogy of Fallot, 648 Conduction system, embryology of, 46 Conduction tissues anatomy of, 28–30, 29f in isomeric atrial appendages, 449 Conduit artery, endothelial function in, 1367–1368, 1368f Confidence, 1488–1493 Confidence intervals, 413 Confluence, 476 Confounding, 411 Congenital Cardiac Anesthesia Society Database, 1511t–1514t Congenital Cardiac Catheterization Project on Outcomes, 1511t–1514t Congenital cardiac disease cardiac and noncardiac surgery in, anesthetic considerations for, 1547–1552 for diagnostic and interventional catheterization, 1551 exposure on brain development, effects of, 1552 management of, 1548–1549 monitoring and vascular access of, 1550 postoperative care, fast-tracking and transition to, 1550–1551 preoperative assessment of, 1547–1548, 1548t preparation and preprocedural sedation of, 1548 copy number variation in, 56 diagnostic catheterization in, 237–252 environmental factors of, 49–50 etiology of cardiac development and, 50–52 epidemiology of, 49–50 etiology of, 49–57 single gene defects, 52–56 exercise testing in, 399–400 genetic factors of, 49–50 genome-wide association studies in, 56–57 large-scale exome sequencing in, 56 new genetics of, 56–57 pharmacogenetics in treatment of, during childhood, 1429–1440 dose-exposure-response relationship, 1430, 1431f, 1432t drug biotransformation, 1431–1435 drug transport, 1433f, 1435 practical applications of, 1435–1438 quality improvement in, 1505–1518 care data registries in, 1510, 1511t–1514t data sources in, 1509–1510 defining outcomes in, 1509 improving outcomes in, 1510–1516 in improving outcomes, role of transparency, 1516–1518 model for, 1505–1506, 1506f patients and their families, 1505 targets for, 1509 variation and, 1506–1509, 1507f–1508f in setting of genetic syndromes, 1407–1420 chromosomal anomalies, 1407–1410, 1408t heterotaxy, 1419–1420 microchromosomal anomalies, 1410–1412 monogenic syndrome, 1412–1419 Congenital Cardiovascular Interventional Study Consortium, 1511t–1514t Congenital complete atrioventricular block, 338–340, 338b, 339f–340f Congenital coronary anomalies, 865–876 anatomy and development of, 865–868, 866t, 866b anomalous aortic origin of the coronary arteries, 865–867, 868f duplication of coronary arteries, 867 ectopic origin of the coronary arteries in, 865, 866f–867f solitary coronary artery, 867–868, 869f anomalous aortic origin of a coronary artery, 873–875, 873f anomalous origin of the left coronary artery from the pulmonary trunk as, 870–872 anomalous right coronary artery from the pulmonary trunk as, 872–873 coronary orificial atresia as, 875–876 developmental considerations in, 869–870, 870f fistulous connections in, 868–869 myocardial bridging, 869 single coronary arteries as, 875 Congenital diaphragmatic hernia, pulmonary hypertension and, 1386 Congenital Evaluation, Reporting, and Tracking Endeavour, 1511t–1514t Congenital heart defects, 1407 cardiac defects of, 1407–1408 in genetic syndrome, 1419t–1420t, 1420 types of, and associated syndromes, 1419–1420 Congenital heart disease (CHD), 1483–1485 adult with, in chronic mechanical circulatory support, 1214 arrhythmias in adults with, 356–357 care, health system challenges in, 1521–1522, 1522t clinical care pathways supporting care of children and young people with, 1481–1485 barriers and challenges, 1483 defining, 1481 development and implementation, 1481–1483, 1482f safety, quality, and effectiveness, 1483 counselor self-awareness in, 165t, 166–167 economic implications of, 185–188

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