abscesses, or ecthyma Genitourinary: purulent urethritis (with dysuria and apparently sterile pyuria), proctitis, or epididymitis PCR-based tests not approved for pharyngeal or rectal swabs due to crossreaction with nongonococcal neisserial species and should not be used for children in whom sexual assault/abuse is suspected or for the diagnosis of gonococcal conjunctivitis (in these cases, cultures should be obtained) HSV, acquired Orolabial: multiple Culture, PCR c vesicles that appear indistinguishable from herpangina, but are not limited • ≥45 kg: ceftriaxone g IV daily for days Conjunctivitis: ceftriaxone g IM once Epididymitis, urethritis: ceftriaxone 250 mg IM once Meningitis or endocarditis: • 45 kg: ceftriaxone 50 mg/kg/day (maximum dose: g/day) IV or IM q12h for 10–14 days for meningitis, 28 days for endocarditis • ≥45 kg: ceftriaxone 1–2 g IV q12h for 10–14 days for meningitis, 28 days for endocarditis Should also be treated empirically for Chlamydia with azithromycin g PO once Acyclovir; alternatives include valacyclovir and famciclovir Topical antiviral therapy is not recommended for