Cardiological abnormalities in Noonan syndrome: phenotypic diagnosis and echocardiographic assessment in 118 patients J Am Coll Cardiol 1993;22:1189–1192 73 Marino B, Digilio MC, Toscano A, et al Congenital heart diseases in children with Noonan sindrome: an expanded cardiac spectrum with high prevalence of atrioventricular canal defect J Pediatr 1999;135:703–706 74 Digilio MC, Marino B, Sarkozy A, et al The heart in Ras-MAPK pathway disorders Karger: Basel; 2009:109–118 Zenker M Noonan Syndrome and Related Disorders Monogr Hum Genet Vol 17 75 Calcagni G, Limongelli G, D'Ambrosio A, et al Cardiac defects, morbidity and mortality in patients affected by RASopathies CARNET study results Int J Cardiol 2017;245:92–98 76 Digilio MC, Marino B, Giannotti A, Dallapiccola B Exclusion of 22q11 deletion in Noonan syndrome with tetralogy of fallot Am J Med Genet 1996;62(4):413–414 77 Digilio MC, Marino B, Picchio F, et al Noonan syndrome and aortic coarctation Am J Med Genet 1998;80(2):160–162 78 Shachter N, Perloff JK, Mulder DG Aortic dissection in noonan's syndrome (46 XY Turner) Am J Cardiol 1984;54(3):464–465 79 Power PD, Lewin MB, Hannibal MC, Glass IA Aortic root dilatation is a rare complication of Noonan syndrome Pediatr Cardiol 2006;27(4):478–480 80 Cornwall JW, Green RS, Nielsen JC, Gelb BD Frequency of aortic dilation in Noonan syndrome Am J Cardiol 2014;113(2):368–371 81 Purnell R, Williams I, Von Oppell U, Wood A Giant aneurysms of the sinuses of valsalva and aortic regurgitation in a patient with Noonan's syndrome Eur J Cardiothorac Surg 2005;28(2):346–348 82 Calcagni G, Baban A, De Luca E, et al Coronary artery ectasia in Noonan syndrome: report of an individual with SOS1 mutation and literature review Am J Med Genet A 2016;170(3):665– 669 83 Ucar T, Atalay S, Tekin M, Tutar E Bilateral coronary artery dilatation and supravalvular pulmonary stenosis in a child with Noonan syndrome Pediatr Cardiol 2005;26(6):848– 850 84 Narayanswami S, Kitchiner D, Smith A Spectrum of valvar abnormalities in Noonan's syndrome A pathologic study Cardiol Young 1994;4:62–66 85 Limongelli G, Pacileo G, Marino B, et al Prevalence and clinical significance of cardiovascular abnormalities in patients with the LEOPARD syndrome Am J Cardiol 2007;100:736–741 86 Gelb BD, Roberts AE, Tartaglia M Cardiomyopathies in Noonan syndrome and other RASopathies Prog Pediatr Cardiol 2015;39:13–19 87 Marino B, Gagliardi MG, Digilio MC, et al Noonan syndrome: structural abnormalities of the mitral valve causing subaortic obstruction Eur J Pediatr 1995;154:949–952 88 Digilio MC, Lepri F, Dentici ML, et al Atrioventricular canal defect in patients with RASopathies Eur J Hum Genet 2013;21:200– 204 89 Lin AE, Alexander ME, Colan SD, et al Clinical, pathological, and molecular analyses of cardiovascular abnormalities in costello syndrome: a Ras/MAPK pathway syndrome Am J Med Genet 2011;155a:486–507 90 Tartaglia M, Zampino G, Gelb BD Noonan syndrome: clinical aspects and molecular pathogenesis Mol Syndromol 2010;1:2–26 91 Digilio MC, Lepri F, Baban A, et al Rasopathies: