Symptoms Signs Respiratory Increased work of breathing Cough Cyanosis Cardiac Pallor Gastrointestinal Poor feeding Vomiting Diarrhea Skin and musculoskeletal Hypothermia Fever Jaundice Floppiness Neurologic Lethargy Irritability Seizures Laboratory abnormalities CBC High WBC count Low WBC count High ANC Tachypnea Desaturations Hyperventilation Respiratory distress (grunting, flaring, retractions) Apnea Tachycardia Bradycardia Hypotension Poor capillary refill Shock Abdominal distention Ileus Low temperature High temperature Hypotonia Petechiae Rash Full anterior fontanelle Hypertonia or hypotonia Meningismus (occasional) Electrolytes: metabolic acidosis, hypernatremia, hyponatremia Liver function tests: hyperbilirubinemia (direct or indirect)