JF, Freedom RM Echocardiographic evaluation of the spectral cardiac anomalies associated with trisomy 18 and 13 J Am Coll Cardiol 1990;15:673–677 32 Costello JP, Weiderhold A, Louis C, et al A contemporary, singleinstitutional experience of surgical versus expectant management of congenital heart disease in trisomy 13 and 18 patients Pediatr Cardiol 2015;36:987–992 33 Kosiv KA, Gossett JM, Bai S, et al Congenital heart surgery on in-hospital mortality in trisomy 13 and 18 Pediatrics 2017;140 [e20170772] 34 Digilio MC, Marino B, Guccione P, et al Deletion 8p sindrome Am J Med Genet 1998;75:534–536 35 Devriendt K, Matthijs G, Van Dael R, et al Delineation of the critical deletion region for congenital heart defects, on chromosome 8p23.1 Am J Hum Genet 1999;64:1119–1126 36 Giglio S, Graw SL, Gimelli G, et al Deletion of a 5-cM region at chromosome 8p23 is associated with a spectrum of congenital heart defects Circulation 2000;102:432–437 37 Digilio MC, Giannotti A, Marino B, Dallapiccola B Atrioventricular canal and 8p- syndrome Am J Med Genet 1993;47:437–438 38 Garg V, Kathiriya IS, Barnes R, et al GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5 Nature 2003;424:443–447 39 Bassett AS, McDonald-McGinn DM, Devriendt K, et al Practical guidelines for managing patients with 22q11.2 deletion sindrome J Pediatr 2011;159:332–339 40 Cancrini C, Puliafito P, Digilio MC, et al Clinical features and follow-up in patients with 22q11.2 deletion syndrome J Pediatr 2014;164:1475– 1480 41 McDonald-McGinn DM, Sullivan KE, Marino B, et al 22q11.2 deletion Nat Rev Dis Primers 2015;19:15071 42 Philip N, Bassett A Cognitive, behavioural and psychiatric phenotype in 22q11.2 deletion syndrome Behav Genet 2011;41:403–412 43 Swillen A, McDonald-McGinn D Developmental trajectories in 22q11.2 deletion Am J Med Genet C Semin Med Genet 2015;169:172–181 44 McDonald-McGinn DM, Kirschner R, Goldmuntz E, et al The Philadelphia story: the 22q11.2 deletion: report on 250 patients Genet Couns 1999;10:11–24 45 Momma K Cardiovascular anomalies associated with chromosome 22q11.2 deletion syndrome Am J Cardiol 2010;105:1617–1624 46 Marino B, Digilio MC, Toscano A, et al Anatomic patterns of conotruncal defects associated with deletion 22q11 Genet Med 2001;3:45–48 47 McElhinney DB, Clark BJ 3rd, Weinberg PM, et al Association of chromosome 22q11 deletion with isolated anomalies of aortic arch laterality and branching J Am Coll Cardiol 2001;37:2114–2119 48 John AS, Rychik J, Khan M, Yang W, Goldmuntz E 22q11.2 deletion syndrome as a risk factor for aortic root dilation in tetralogy of fallot Cardiol Young 2014;24:303–310 49 Momma K, Ando M, Matsuoka R Truncus arteriosus communis associated with chromosome 22q11 deletion J Am Coll Cardiol 1997;30:1067–1071 50 Marino B, Digilio MC, Persiani M, et al Deletion 22q11 in patients with interrupted aortic arch Am J Cardiol 1999;84:360–363 51 Marino B, Digilio MC, Toscano A, et al Deficiency of the infundibular septum in patients with interrupted aortic arch and del 22q11 Cardiol Young 2000;10:428–429 52 Michielon G, Marino B, Formigari R, et al Genetic syndromes and outcome after surgical