Suspect neonatal sepsis in any newborn presenting with hypothermia, respiratory distress, hypoperfusion, or feeding difficulty Any neonate presenting with a concern for infection should be hospitalized until cultures are proven negative Apnea is a common presentation of viral upper respiratory tract infections (including respiratory syncytial virus infection) in a neonate Enteroviral infections are more severe in the neonate than children, resulting in meningitis, acute fulminant hepatitis, and heart failure from myocarditis RELATED CHAPTERS Signs and Symptoms Apnea: Chapter 14 Cyanosis: Chapter 21 Fever: Chapter 31 Septic-Appearing Infant: Chapter 73 Tachycardia: Chapter 77 Medical, Surgical, and Trauma Emergencies Dermatologic Urgencies and Emergencies: Chapter 88 Infectious Disease Emergencies: Chapter 94 The Children’s Hospital of Philadelphia Clinical Pathway ED Clinical Pathway for Evaluation/Treatment of Febrile Young Infants (0–56 Days Old) URL: https://www.chop.edu/clinical-pathway/febrile-infant-emergentevaluation-clinical-pathway Authors: R Scarfone, MD; P Gala, MD; A Murray, MD; M.K Funari, RN; J Lavelle, MD; L Bell, MD; C Jacobstein, MD Posted: August 2010, last revised August 2019 Neonatal Sepsis CLINICAL PEARLS AND PITFALLS