TABLE 96.6 EXAMPLES OF HYPOTONIA AND NEUROMUSCULAR DISEASE Anterior horn cell Motor and sensory neuropathies Neuromuscular junction Congenital myopathy Muscular dystrophy Metabolic and multisystem disease Spinal muscular atrophies Infantile neuronal degeneration Neurogenic arthrogryposis Hypomyelinating neuropathy Charcot–Marie–Tooth disease Hereditary sensory and autonomic neuropathy Acquired transient neonatal myasthenia Congenital myasthenia Infantile botulism Magnesium toxicity Aminoglycoside toxicity Nemaline myopathy Myotubular myopathy Congenital muscular dystrophy Walker–Warburg syndrome Muscle–eye–brain disease Duchenne dystrophy Mitochondrial disorder Peroxisomal disorder Neonatal adrenoleukodystrophy Cerebrohepatorenal syndrome Pompe disease Severe neonatal phosphofructokinase deficiency Severe neonatal phosphorylase deficiency Neonatal Abstinence Syndrome Goals of Treatment It is estimated that over 4% of pregnant women abuse one or more substances during pregnancy—both legal and illicit substances The goals of treatment are to distinguish the infant suffering from neonatal abstinence syndrome (NAS) and