Temperature regulation can also be altered in infants with hypoxic–ischemic injury In patients presenting with hypoxia–ischemia (e.g., after cardiac arrest), fever should be aggressively prevented because hyperthermia can worsen neurologic injury COLOR CHANGES AND DERMATOLOGIC FINDINGS Goals of Emergency Care The goal is to recognize the difference between benign presentations, such as acrocyanosis, and life-threatening conditions, such as true cyanosis and pallor KEY POINTS Evaluation of jaundice requires assessment of both direct and indirect bilirubin Acceptable levels of indirect hyperbilirubinemia depend on both prematurity and postnatal age Many neonates with herpes simplex virus (HSV) infection have a negative maternal history of HSV RELATED CHAPTERS Signs and Symptoms Cyanosis: Chapter 21 Jaundice: Conjugated Hyperbilirubinemia and Jaundice: Unconjugated Hyperbilirubinemia: Chapters 44 and 45 Pallor: Chapter 62 Rash: Neonatal: Chapter 69 Septic-Appearing Infant: Chapter 73 Medical, Surgical, and Trauma Emergencies Cardiac Emergencies: Chapter 86 Dermatologic Urgencies and Emergencies: Chapter 88 The Children’s Hospital of Philadelphia Clinical Pathways