Drug Complications Asparaginase • Allergy • Hemorrhage • Deep and superficial vein thrombosis (cerebral sinus venous thrombosis) • Hyperglycemia • Pulmonary fibrosis and/or pneumonitis Bleomycin Anthracyclines (doxorubicin, daunorubicin) • Cardiomyopathy Corticosteroids • Avascular necrosis • Hyperglycemia Cyclophosphamide • SIADH • Hemorrhagic cystitis Cyclosporine • Hypomagnesemia and seizures Cytarabine • Neurotoxicity (cerebellar dysfunction, onset within hours of treatment with high doses) • Eye pain, tearing, sensitivity to light and blurred vision (high doses) • Seizures (high doses) • Erythroderma, especially palmar, with resulting desquamation (high doses) Dactinomycin • Venoocclusive disease of the liver Etoposide • Hypotension (during infusion) Ifosfamide • Salt wasting • Neurotoxicity (confusion, inappropriate laughter, somnolence, psychosis) • Renal injury manifested as Fanconi syndrome with proximal tubular dysfunction and wasting of phosphate, glucose, potassium, and bicarbonate • Hemorrhagic cystitis Methotrexate • Seizures • Elevated transaminases (1–3 days after high-dose administration)