FIGURE 96.1 Congenital heart disease screening algorithm (Reproduced with permission from Kemper AR, Mahle WT, Martin GR, et al Strategies for implementing screening for critical congenital heart disease Pediatrics 2011;128(5):e1259–1267 Copyright © 2011 American Academy of Pediatrics.) Supplemental oxygen should be administered to infants with suspected or confirmed respiratory disease Hypoxic premature infants with lung disease should be administered oxygen judiciously, particularly if they have not corrected to term gestation Hyperoxia is associated with retinopathy of prematurity, increased risk of pneumonia, and exacerbations of chronic lung disease Target saturations for this population should be discussed with a neonatologist Similarly, oxygen administration to infants with CHD can alter pulmonary