platelets Takes time to arrange; generally unable to obtain in the ED Single donor Preferred c No Premedication Possible Possible Quantity General guidelines: unit 80 kg a Not Highly transfused population are at risk for reactions Acetaminophen if h/o febrile reactions Diphenhydramine if h/o allergic reaction Hydrocortisone if h/o allergic reaction despite diphenhydramine or very severe allergic reaction pRBC elective Volume-reduced transfusion: platelets in patients very 10–15 mL/kg or sensitive to units for >50-kg volume overload patient decrease effectiveness of transfusion Continuous infusion for plateletrefractory patient with ongoing significant bleeding required if type previously performed at blood bank product unnecessary if product has been leukoreduced c Apheresis platelets from a single donor preferred b CMV-negative