TABLE 101.15 Pathology of Kawasaki Disease a Stage I—Disease duration 50 days Scar formation, calcification in coronary arteries Stenosis and recanalization of coronary vessel lumen Myocardial fibrosis without acute inflammation a Duration of each stage may be decreased by prompt treatment with IVIG IVIG, intravenous immunoglobulin Goals of Treatment Early recognition of the symptoms of KD is essential to effective and timely therapy Although no definitive test for KD exists, recognition of the constellation of signs and symptoms is instrumental in making the diagnosis The goals of treatment are to reduce the amount of ectasia and aneurysms that occur among the coronary arteries which can be accomplished by the initiation of IVIG therapy within the first 10 days of the illness Clinical Considerations Clinical Recognition KD is a clinical syndrome diagnosed on the basis of fever and four of the five signs of mucocutaneous inflammation ( Table 101.16 ) These diagnostic criteria should be regarded as imperfect, with