Poison Acetaminophen Antidote N -acetylcysteine; intravenous (IV)—150 mg/kg over hr, then 12.5 mg/kg/hr for hrs, then 6.25 mg/kg/hr; enteral—140 mg/kg, then 70 mg/kg every hrs Anticholinergics Physostigmine (adult, 0.5–2 mg; child, 0.02 mg/kg) slow IV; may repeat in 15 until desired effect is achieved; subsequent doses every 2–3 hrs PRN (Caution: May cause seizures, asystole, cholinergic crisis; see text ) Anticholinesterases Atropine, 2–5 mg (adults); 0.05–0.1 mg/kg (children) intramuscular (IM) or IV, repeated every 2–10 until atropinization is evident Organophosphates Pralidoxime chloride 1–2 g (adults); 25–50 mg/kg (children) IV; repeat dose in hr PRN, then every 6– hrs for 24–48 hrs (consider also constant infusion; see text) Carbamates Atropine, as above; pralidoxime for severe cases (see text) Benzodiazepines Flumazenil, 0.01 mg/kg IV (use with caution; see text) β-Adrenergic blockers Glucagon, 0.1 mg/kg IV, followed by 0.05 mg/kg/hr Calcium channel Calcium chloride 10%, 10 mL (adult); 0.2 mL/kg blockers (pediatric) IV Or Calcium gluconate 10%, 30 mL (adult); 0.6 mL/kg (pediatric) IV High-dose insulin unit/kg bolus followed by 0.5 units/kg/hr, with glucose infusion titrated to prevent hypoglycemia Carbon monoxide Oxygen 100% inhalation, consider hyperbaric for severe cases Cyanide— Adult: Amyl nitrite inhalation (inhale for 15–30 s every nitrites/thiosulfate 60 s) pending administration of 300-mg sodium nitrite (10 mL of a 3% solution) IV slowly (over 2–4 min); follow immediately with 12.5-g sodium