has been used effectively to stabilize refractory hypoglycemia at a suggested dose of to µg/kg/dose every to 12 hours via either an IV or subcutaneous route Drugs Dangerous in Small Doses Toddlers often are brought to EDs for evaluation after possibly having ingested one or two doses of a medication Most often these children will be fine with little treatment beyond reassurance There are circumstances, however, when this situation can be life threatening and proper intervention can be lifesaving A large list of chemicals and poisons can be extremely toxic in small amounts; but, this is beyond the scope of this discussion However, it is wise to be familiar with a modest list of pharmaceuticals that may cause dangerous toxicity to young children with just one or two doses ( Table 102.13 ) Many of these agents have been discussed earlier in this chapter The actual incidence of life-threatening toxicity of each of these drugs, when just one or two doses have been ingested, is as yet undefined A systematic approach to these patients includes a careful history, an examination with attention to the presence of toxidromes ( Table 102.6 ), and a guided laboratory assessment This approach may allow narrowing of the differential diagnosis and may allow a determination of the possible severity of the ingestion If the differential diagnosis includes any of the drugs listed in Table 102.13 , it may be prudent to consider decontamination and prolonged observation An algorithmic approach to this situation is provided in Figure 102.5 NONPHARMACEUTICALS Alcohols and Glycols CLINICAL PEARLS