Pediatric emergency medicine trisk 3048 3048

Naloxone Naloxone, a pure opioid receptor antagonist, is one of the safest and most effective of the true antidotes now available It is effective against all opioids Naloxone is a synthetic congener of oxymorphone but is devoid of morphine agonist or depressant effects It has no significant side effects in the treatment of acute overdose except narcotic withdrawal symptoms in the addicted patient Withdrawal symptoms secondary to naloxone, if observed during acute overdose treatment, would be expected to last no more than 30 minutes and should generally be treated with supportive care The serum half-life of naloxone is hour; its duration of action is to hours Initial reversal of narcosis may then revert to coma, requiring ongoing reassessment and readministration of naloxone There are a few case reports of other adverse effects, including hypertension, pulmonary edema, ventricular irritability, and seizures after naloxone-induced reversal of narcosis in the perioperative setting, typically in patients with underlying cardiopulmonary disease and in the presence of additional medications or anesthetic agent use