ED Clinical Pathway for Evaluation/Treatment of Sickle Cell Disease With Fever URL: https://www.chop.edu/clinical-pathway/sickle-cell-disease-with-feverclinical-pathway Authors: A Ellison, MD; J Lavelle, MD; C Jacobstein, MD; C Norris, MD; R Cecil, RN, MSN; T McKnight, CRNP; H Hartung, MD; K Smith Whitley, MD Posted: January 2010, last revised March 2020 ED Clinical Pathway for Evaluation/Treatment of Sickle Cell Disease and Pain URL: https://www.chop.edu/clinical-pathway/sickle-cell-disease-with-painclinical-pathway Authors: J Umana, MD; A Ellison, MD; J Fuchs, RN; M Wengler, CRNP; H Huang, Pharm D; C Norris, MD; K Smith-Whitley, MD; C Jacobstein, MD; J Lavelle, MD Posted: July 2010, last revised March 2020 ED Clinical Pathway for Evaluation/Treatment of Children With Hemophilia and Closed Head Injury (CHI) URL: https://www.chop.edu/clinical-pathway/hemophilia-with-head-traumaclinical-pathway Authors: R Butler; L Raffini, MD; C Witmer, MD; C Jacobstein, MD; J Lavelle, MD Posted: August 2005, last revised October 2019 ANEMIA Goals of Treatment Severe anemia requires rapid evaluation and treatment to prevent hypoxia, congestive heart failure, end-organ damage, and death When the etiology of the anemia is not immediately apparent, management focuses simultaneously on diagnostic and therapeutic interventions Many management strategies for the anemic child are similar regardless of etiology, but special considerations are necessary in the setting of a destructive red cell process CLINICAL PEARLS AND PITFALLS