Children and adolescents experience an array of oral lesions not associated with signs of systemic disease that are typically further delineated by considering the type of lesion (i.e., mass, vesicle, ulcer) and whether they are painful Most of these processes require little or no therapy, although rhabdomyosarcoma and other malignancies are obvious exceptions to this observation Suggested Readings and Key References Esmeili T, Lozada-Nur F, Epstein J Common benign oral soft tissue masses Dent Clin North Am 2005;49:223–240 Kulbersh BD, Wiatrak BJ Pediatric lingual and other intraoral lesions Otolaryngol Clin North Am 2015:48;175–190 Patton LL Oral lesions associated with human immunodeficiency virus disease Dent Clin North Am 2013;57:673–698 Pinto A, Haberland CM, Baker S Pediatric soft tissue oral lesions Dent Clin North Am 2014;58:437–453 Yuhan BT, Svider PF, Mutchnick S, et al Benign and malignant oral lesions in children and adolescents: an organized approach to diagnosis and management Pediatr Clin North Am 2018:65;1033–1050