Br J Dermatol 2012;167:424–432 Hung SI, Chung WH, Liou LB, et al HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol Proc Natl Acad Sci U S A 2005;102:4134–4139 Lee HY, Lim YL, Thirumoorthy T, et al The role of intravenous immunoglobulin in toxic epidermal necrolysis: a retrospective analysis of 64 patients managed in a specialized centre Br J Dermatol 2013;169:1304–1309 Mallal S, Nolan D, Witt C, et al Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir Lancet 2002;359:727–732 Sassolas B, Haddad C, Mockenhaupt M, et al ALDEN, an algorithm for assessment of drug causality in Stevens-Johnson syndrome and toxic epidermal necrolysis: comparison with case-control analysis Clin Pharmacol Ther 2010;88:60–68 Wootton CI, Patel AN, Williams HC In a patient with toxic epidermal necrolysis, does intravenous immunoglobulin improve survival compared with supportive care? Arch Dermatol 2011;147:1437–1440