intrauterine system (Mirena IUS) Consultation to adolescent medicine, hematology, or gynecology may be warranted TABLE 92.6 CONTRAINDICATIONS TO THE USE OF ESTROGEN-CONTAINING MEDICATIONS History of migraine with aura History of venous thromboembolism (deep venous thromboembolism, pulmonary embolism, stroke) Inherited prothrombotic disorders Systemic lupus erythematosus with positive or unknown antiphospholipid antibodies Hypertension (SBP >160 mm Hg or DBP >100 mm Hg) Certain heart conditions (ischemic heart disease, complicated valvular disease, peripartum cardiomyopathy) Certain liver conditions (hepatocellular adenoma, liver malignancy, severe cirrhosis) Postpartum