Previously diagnosed patients with psoriasis may be receiving other topical agents, including a variety of other more or less potent topical steroids, tar derivatives, topical vitamin A derivatives (tazarotene), topical vitamin D agents, emollients, and ultraviolet light For severe cases, patients may be receiving treatment with systemic immunomodulating agents, including methotrexate, cyclosporine, acitretin, and a variety of biologic modifiers that address specific targets in T-cell physiology Patients with pustular or erythrodermic flares of their psoriasis may warrant admission in order to better control their disease, using more intensive wet wrap therapies with topical steroids or initiation of systemic immunomodulating therapies Patients with extensive skin involvement and skin barrier dysfunction may be at risk for hypothermia, skin infection, bacteremia, and electrolyte abnormalities, and should be evaluated accordingly Older patients with psoriasis are also at higher risk for cardiovascular disease and lipid abnormalities such as hypertriglyceridemia and hypercholesterolemia Seborrheic Dermatitis Seborrheic dermatitis is an inflammatory skin disorder characterized by salmon-colored erythema and greasy scale concentrated on areas rich in sebum production, including the scalp, eyebrows, ears, perinasal areas, beard areas, and less commonly, the midchest, axillary, and inguinal areas ( Fig 70.6 ) Despite the intensity of the rash, pruritus is often mild or nonexistent