Indirect immunofluorescence can be performed to test for circulating antibodies Circulating IgG is found in bullous pemphigoid; circulating IgA is found in CBDC CONCLUSION Vesiculobullous diseases have a variety of presentations and several key features that may help to distinguish them from one another While characteristic features in some make diagnosis straightforward, many of the blistering disorders require further diagnostic evaluation in order to confirm diagnosis Treatment is aimed at the underlying pathogenesis Suggested Readings and Key References Chandler DJ, Fuller LC A review of scabies: an infestation more than skin deep Dermatology 2019;235(2):79–90 Fine JD, Bruckner-Tuderman L, Eady RA, et al Inherited epidermolysis bullosa: updated recommendations on diagnosis and classification J Am Acad Dermatol 2014;70(6):1103–1126 Fine JD, Mellerio JE Extracutaneous manifestations and complications of inherited epidermolysis bullosa: part I Epithelial associated tissues J Am Acad Dermatol 2009;61(3):367–384; quiz 385–386 Fine JD, Mellerio JE Extracutaneous manifestations and complications of inherited epidermolysis bullosa: part II Other organs J Am Acad Dermatol 2009;61(3):387–402; quiz 403–404 Juckett G Arthropod bites Am Fam Physician 2013;88(12):841–847 Lai-Cheong JE, McGrath JA Kindler syndrome Dermatol Clin 2010;28(1):119– 124 Lara-Corrales I, Pope E Autoimmune blistering diseases in children Semin Cutan Med Surg 2010;29(2):85–91 Méni C, Bruneau J, Georgin-Lavialle S, et al Paediatric mastocytosis: a systematic review of 1747 cases Br J Dermatol 2015;172(3):642–651 Mintz EM, Morel KD Clinical features, diagnosis, and pathogenesis of chronic bullous disease of childhood Dermatol Clin 2011;29(3):459–462, ix Pavlek L, Schmidt J Visual diagnosis: vesicular rash in a neonate Pediatr Rev 2017;38(9):e32–e34 Sansaricq F, Stein SL, Petronic-Rosic V Autoimmune bullous diseases in childhood Clin Dermatol 2012;30(1):114–127 Torrelo A, Alvarez-Twose I, Escribano L Childhood mastocytosis Curr Opin Pediatr 2012;24(4):480–486