lymphadenopathy and splenomegaly Finally HIV infection causes adenopathy in the cervical, axillary, and inguinal regions, particularly during the acute phase of infection Nodes generally decrease in size after the first to weeks as the immune response to infection subsides, however a modest degree of adenopathy can persist Children with unexplained recurrent or opportunistic infections, fevers, failure to thrive, hepatosplenomegaly, and generalized adenopathy should be evaluated for HIV infection