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Chorioamnionitis is usually due to group B streptococcal or Escherichia coli infections Ampicillin and gentamycin are reasonable empiric antibiotics in a newly born infant with suspected chorioamnionitis (see Chapters 73 SepticAppearing Infant and 94 Infectious Disease Emergencies ) POSTRESUSCITATION CARE Once effective ventilation and circulation are established, the infant should be continuously monitored and safely transported to a neonatal unit or a facility with a neonatal unit These infants are at tremendous risk for deterioration even after their vital signs have returned to normal The patient should be transported by personnel with appropriate expertise along with appropriate equipment and medications SPECIAL SITUATIONS Withholding Resuscitation There is no validated prognostic score to guide determination of initiation of resuscitation in infants born at less than 25 weeks’ gestational age Decisions about appropriateness of resuscitation below 25 weeks’ gestational age should be influenced by region-specific guidelines These decisions should be individualized, based on available resources, and inclusive of mother and family Discontinuing Resuscitative Efforts An Apgar score of at 10 minutes is a strong predictor of mortality and morbidity in late preterm and term infants Therefore, if the HR remains undetectable following 10 minutes of resuscitation, it likely is futile to continue assisted ventilation These decisions should be individualized, based on available resources, and inclusive of mother and family Induced Therapeutic Hypothermia Data from large, multicenter, randomized controlled trials have demonstrated that systemic or selective head cooling hypothermia initiated within hours of life, in infants ≥36 weeks reduced death or neurologic disability in infants with moderate or severe hypoxic-ischemic encephalopathy The American Academy of Pediatrics (AAP) Committee on Fetus and Newborn and the AHA guidelines recommend that infants ≥36 weeks’ gestation who have moderate to severe hypoxic encephalopathy be offered therapeutic hypothermia Currently, hypothermia therapy is not recommended for infants less than 36 weeks’ gestation as clinical trials are needed for this age group